A5075293871- Pharmacogenetics and Drug Metabolism
- Nicotinic Acetylcholine Receptors Study
- Monoclonal and Polyclonal Antibodies Research
- Pharmaceutical studies and practices
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Pharmacological Effects and Toxicity Studies
- Drug Solubulity and Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
- Smoking Behavior and Cessation
- Opioid Use Disorder Treatment
- Anesthesia and Sedative Agents
- Nanoparticles: synthesis and applications
- Estrogen and related hormone effects
- Biosimilars and Bioanalytical Methods
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
- Inflammatory Bowel Disease
- Inhalation and Respiratory Drug Delivery
- Poisoning and overdose treatments
- Drug Transport and Resistance Mechanisms
Saarland University
2020-2022
Florida College
2020
University of Florida
2020
Buprenorphine plays a crucial role in the therapeutic management of pain adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic studies buprenorphine children, particularly neonates, are available as conducting clinical trials this population is especially challenging. Physiologically-based (PBPK) modeling allows prediction drug exposure pediatrics based on age-related physiological differences. The aim study was to predict pharmacokinetics with PBPK modeling....
Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult pediatric populations. Yet, only few pharmacokinetic studies of fentanyl pediatrics exist as conducting clinical trials this population especially challenging. Physiologically-based (PBPK) modeling a mechanistic approach to explore drug pharmacokinetics allows extrapolation from populations based on age-related physiological differences. The aim study was develop PBPK model norfentanyl established PK-Sim® using...
Infliximab is approved for treatment of various chronic inflammatory diseases including bowel disease (IBD). However, high variability in infliximab trough levels has been associated with diverse response rates. Model-informed precision dosing (MIPD) population pharmacokinetic models could help to individualize regimens and improve therapy. The aim this study was evaluate the predictive performance published IBD patients an external data set. set consisted 105 336 concentrations. Literature...
Nicotine, the pharmacologically active substance in both tobacco and many electronic cigarette (e-cigarette) liquids, is responsible for addiction that sustains smoking. With 8 million deaths worldwide annually, smoking remains one of major causes disability premature death. However, nicotine also plays an important role cessation strategies. The aim this study was to develop a comprehensive, whole-body, physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model its metabolite...
A better understanding of their interaction with cell-based tissue is a fundamental prerequisite towards the safe production and application engineered nanomaterials. Quantitative experimental data on correlation between physicochemical characteristics transport nanomaterials across biological barriers, in particular, still scarce, thus hampering development effective predictive non-testing strategies. Against this background, presented study investigated translocation gold silver...
Static in vitro permeation experiments are commonly used to gain insights into the properties of drug substances but exhibit limitations due missing physiologic cell stimuli. Thus, fluidic systems integrating stimuli, such as physicochemical fluxes, have been developed. However, studies display higher complexity compared static systems, analysis experimental readouts is challenging. Here, integration silico tools holds potential evaluate and investigate specific simulation scenarios. This...
Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation more than 50 years. However, since (E)-clomiphene ((E)-Clom) and its metabolites are eliminated primarily via Cytochrome P450 (CYP) 2D6 CYP3A4, exposure can be affected by CYP2D6 polymorphisms concomitant use with CYP inhibitors. Thus, clomiphene therapy may susceptible to drug–gene interactions (DGIs), drug–drug (DDIs) drug–drug–gene (DDGIs). Physiologically based pharmacokinetic...