A5039259160- Neurological disorders and treatments
- Immunotherapy and Immune Responses
- Transcranial Magnetic Stimulation Studies
- Cerebral Palsy and Movement Disorders
- CAR-T cell therapy research
- Botulinum Toxin and Related Neurological Disorders
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Clinical Reasoning and Diagnostic Skills
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- T-cell and B-cell Immunology
- Radiology practices and education
- Parkinson's Disease Mechanisms and Treatments
- Surgical site infection prevention
- Health Systems, Economic Evaluations, Quality of Life
- Neurogenetic and Muscular Disorders Research
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Advanced Causal Inference Techniques
- Healthcare Policy and Management
- Genomics and Chromatin Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Innovations in Medical Education
Roche (Switzerland)
2017-2024
Statistical Research (United States)
2022
Inserm
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Institut Gustave Roussy
2018
Université Paris-Sud
2018
Centre de recherche en Epidémiologie et Santé des Populations
2018
King's College London
2015-2017
Evelina London Children's Healthcare
2015-2017
London School of Hygiene & Tropical Medicine
2015-2017
The expression of eukaryotic genes is regulated by cis-regulatory elements such as promoters and enhancers, which bind sequence-specific DNA-binding proteins. One the great challenges in gene regulation field to characterise these elements. This involves identification transcription factor (TF) binding sites within regulatory that are occupied a defined context. Digestion with DNase subsequent analysis regions protected from cleavage (DNase footprinting) has for many years been used identify...
Purpose Bevacizumab (BEV) is approved in more than 60 countries for use adults with recurrent glioblastoma. We evaluated the addition of BEV to radiotherapy plus temozolomide (RT+TMZ) pediatric patients newly diagnosed high-grade glioma (HGG). Methods The randomized, parallel group, multicenter, open-label HERBY trial ( ClinicalTrials.gov identifier: NCT01390948) enrolled age ≥ 3 years ≤ 18 localized, centrally neuropathology-confirmed, nonbrainstem HGG. Eligible were randomly assigned...
Abstract Cibisatamab is a bispecific antibody-based construct targeting carcinoembryonic antigen (CEA) on tumour cells and CD3 epsilon chain as T-cell engager. Here we evaluated cibisatamab for advanced CEA-positive solid tumours in two open-label Phase 1 dose-escalation -expansion studies: single agent with or without obinutuzumab S1 (NCT02324257) atezolizumab S2 (NCT02650713). Primary endpoints were safety, dose finding, pharmacokinetics S1; safety finding S2. Secondary anti-tumour...
Outcome for patients with metastatic rhabdomyosarcoma (RMS) is poor. This study presents the results of MTS 2008 a pooled analysis including from concurrent BERNIE study.
<h3>Background</h3> The pathophysiology underlying different types of dystonia is not yet understood. We report microelectrode data from the globus pallidus interna (GPi) and externa (GPe) in children undergoing deep brain stimulation (DBS) for investigate whether GPi GPe firing rates differ between types. <h3>Methods</h3> Single pass were obtained to guide electrode position 44 (3.3–18.1 years, median 10.7) with following types: 14 primary, 22 secondary Static 8 progressive neuronal iron...
Aim Hyperkinetic movement disorders ( HMD s) can be assessed using impairment‐based scales or functional classifications. The Burke–Fahn–Marsden Dystonia Rating Scale‐movement BFM ‐M) evaluates dystonia impairment, but may not reflect ability. Gross Motor Function Classification System GMFCS ), Manual Ability MACS and Communication CFCS ) are widely used in the literature on cerebral palsy to classify ability, childhood disorders. We explore concordance of these three a large sample...
Timely progression through school is an important measure for performance, completion and the onset of other life transitions adolescents. This study examines risk factors grade repetition establishes extent to which age-for-grade heterogeneity contributes subsequent at early later stages school. Using data from a demographic surveillance site in Karonga district, northern Malawi, cohort 8174 respondents (ages 5-24 years) primary was followed 2010 observed 2011. Grade more common among those...
• A high proportion (47%) of children with dystonia have evidence abnormal sensory pathway function. Central motor conduction times (CMCTs) and somatosensory evoked potentials (SEPs) show a significant relationship deep brain stimulation (DBS) outcome, independent aetiology or cranial MRI. CMCTs SEPs can guide patient selection help counsel families about potential benefit DBS. To report Somatosensory Evoked Potentials Motor Conduction Times (CMCT) in to test the hypothesis that these...
The vigilance decrement describes a decrease in sensitivity or increase specificity with time on task. It has been observed variety of repetitive visual tasks, but little is known about these patterns radiologists. We investigated whether there systematic variation performance over the course radiology reading session. re-analyzed data from six previous lesion-enriched studies. Studies featured 8–22 participants assessing 27–100 cases (including mammograms, chest CT, x-ray, and bone x-ray)...
With the advance of genome sequencing technologies, phenotyping, rather than genotyping, is becoming most expensive task when mapping genetic traits. The need for efficient selective phenotyping strategies, i.e. methods to select a subset genotyped individuals therefore increases. Current have focused either on improving detection causative variants or their precise genomic location separately. Here we recognize as Bayesian model discrimination problem and introduce SPARE (Selective...
Dendritic cells (DCs) are the most potent antigen-presenting and key link between innate adaptive immune response. Only a few reports with study populations of up to 50 individuals have been published age-based reference values for DC subpopulations in healthy children. Therefore, we aimed establish ranges larger population 100 children, which allowed age-matched subgroups. Most previous studies were performed using dual-platform approach. In this study, single-platform approach lyse no-wash...
Atezolizumab is approved as an intravenous (IV) infusion for use a single agent and in combination with other therapies number of indications. The objectives this publication are to characterize atezolizumab pharmacokinetics (PK) across indications the available clinical data from one phase I eight III studies, determine exposure-response (ER) relationships settings variety tumor types, provide safety support extension 840 mg q2w, 1200 q3w, 1680 q4w IV dosing regimens various settings....
The radiologist’s task of reviewing many cases successively is highly repetitive and requires a high level concentration. Fatigue effects have, for example, been shown in studies comparing performance at different times day. However, little known about changes during an individual reading session. During session enriched case set, may be affected by both fatigue (i.e. decreasing performance) training increasing effects. In this paper, we reanalyze 3 datasets from 4 radiologist Studies...
With the development of novel treatment therapies as well evolving and innovative approaches to conduct clinical trials, landscape pediatric oncology drug has dramatically changed in recent years. Despite this change, approvals for new drugs labeling updates ensure availability proper patients with cancer remain slow. The context tumors also regulatory initiatives US Europe, creating a great need faster drugs. Today, conventional study designs have been replaced or complemented by trial...
Abstract Background We conducted an integrated analysis of clinical data to describe long‐term effects bevacizumab on growth and bone development in pediatric adolescent patients with solid tumors. Procedure Clinical were pooled from five phase I/II trials versus chemotherapy: BERNIE, HERBY, AVF4117s enrolled newly diagnosed patients, AVF3842s AVF2771s relapsed/refractory disease. Height, weight, body mass index (BMI), bone‐age by treatment group. Growth charts used track monitor relation a...
10541 Background: Local control is a key part of treatment local/locoregional rhabdomyosarcoma (RMS) and often involves radiotherapy (RT) with/without surgery. The role RT in metastatic RMS uncertain, with little published evidence to guide clinicians. We analyzed data from the BERNIE trial assess benefit for patients (pts) RMS. Methods: In study (NCT00643565) pts aged ≥6 months <18yrs non-RMS soft tissue sarcoma were randomized receive chemotherapy (CT) bevacizumab (BEV), surgery, and/or...