A5100409604- Redox biology and oxidative stress
- Genomics, phytochemicals, and oxidative stress
- Augmented Reality Applications
- Interactive and Immersive Displays
- Glutathione Transferases and Polymorphisms
- PI3K/AKT/mTOR signaling in cancer
- Quinazolinone synthesis and applications
- RNA Interference and Gene Delivery
- Robotics and Automated Systems
- Hand Gesture Recognition Systems
- Advanced Optical Imaging Technologies
- Computer Graphics and Visualization Techniques
- Gaze Tracking and Assistive Technology
- Curcumin's Biomedical Applications
- DNA Repair Mechanisms
- Genetic and Kidney Cyst Diseases
- Advanced Vision and Imaging
- Renal and related cancers
- 3D Shape Modeling and Analysis
- Immune cells in cancer
- Medicinal Plants and Bioactive Compounds
- Natural product bioactivities and synthesis
- TGF-β signaling in diseases
- Human Pose and Action Recognition
- Cancer, Hypoxia, and Metabolism
Korea Research Institute of Bioscience and Biotechnology
2011-2025
Korea Institute of Toxicology
2022-2025
Institute for Basic Science
2023-2024
Kyungpook National University Hospital
2024
Ewha Womans University
2013-2023
Catholic University of Korea
2022
Chung-Ang University
2020-2021
Electronics and Telecommunications Research Institute
2014-2019
Korea Atomic Energy Research Institute
2013
Chonnam National University
2011
Ionizable lipid nanoparticles (LNPs) have been widely used for in vivo delivery of RNA therapeutics into the liver. However, a main challenge remains to develop LNP formulations selective certain types liver cells, such as hepatocytes and sinusoidal endothelial cells (LSECs). Here, we report engineered LNPs targeted LSECs. The effects particle size polyethylene glycol-lipid content were evaluated hepatocyte-specific mRNA by ApoE-mediated cellular uptake through low-density lipoprotein...
Various herbal extracts containing luteolin-7-O-glucuronide (L7Gn) have been traditionally used to treat inflammatory diseases. However, systemic studies aimed at elucidating the anti-inflammatory and anti-oxidative mechanisms of L7Gn in macrophages are insufficient. Herein, effects their underlying action were explored. inhibited nitric oxide (NO) production lipopolysaccharide (LPS)-stimulated RAW 264.7 by transcriptional regulation inducible NO synthase (iNOS) a dose-dependent manner. The...
As neighborhood walkability has gradually become an important topic in various fields, many cities around the world are promoting eco-friendly and people-centered walking environment as a top priority urban planning. The purpose of this study is to visualize physical perceived detail analyze differences prepare alternatives for improving neighborhood’s environment. area Jeonju City, one medium-sized Korea. For evaluation walkability, 196,624 street view images were crawled 127,317 pairs...
Elucidation of the interplay between viruses and host cells is crucial for taming to benefit human health. Cancer therapy using adenovirus, called oncolytic virotherapy, a promising treatment option but not robust in all patients. In addition, inefficient replication adenovirus mouse hampered development an vivo model preclinical evaluation therapeutically engineered adenovirus. nc886 non-coding RNA that suppresses Protein Kinase R (PKR), antiviral protein. this study, we have found greatly...
Spiraea prunifolia: var. simpliciflora (SP) is a known medical food that used to treat emesis, malaria, and fever. This study investigated the therapeutic potential of SP leaf extract on oxidative stress airway inflammation using chronic obstructive pulmonary disease (COPD) mouse model induced by porcine pancreatic elastase (PPE) lipopolysaccharide (LPS). Male C57BL/6N mice were treated intratracheal instillation PPE (0.05 units/50 μL) LPS (5 μg/50 μL), administered positive control...
Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used to treat inflammatory diseases induces cellular toxicity by increasing the production of reactive oxygen species (ROS) and impairing autophagic flux. In this study, we investigated whether diclofenac cancer cell death mechanism which causes death. We observed that mitotic arrest with half-maximal effective concentration 170 μM lethal dose 200 µM during 18-h incubation in HeLa cells. Cellular microtubule imaging vitro tubulin...
Radio-resistance resulting from radiotherapy-induced fibrosis is a major clinical obstacle in breast cancer treatment because it typically leads to recurrence, failure, and patient death. Transforming growth factor-β (TGF-β) key signal messenger fibrosis, which plays an important role radiation-induced stem cell (CSC) development, may be mediated through the generation of oxidative stress. This study was conducted confirm efficacy vactosertib, TGF-β/ALK5 inhibitor, as potent inhibitor stress...
Acquired metastasis and invasion of cancer cells during radiotherapy are in part due to induction epithelial-to-mesenchymal transition (EMT) stem cell (CSC) properties, which mediated by TGF-β signaling. Here we evaluated the anti-metastatic therapeutic potential vactosertib, an orally bioavailable type I receptor (activin receptor-like kinase 5, ALK5) inhibitor, via suppression radiation-induced EMT CSC oxidative stress generation, breast lung a mouse model lines.Co-treatment vactosertib...
Collapsin response mediator protein (CRMP)-2 and the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are associated with common physiological functions such as neuronal polarity, axonal outgrowth, synaptic strength, well various brain disorders including epilepsy. But, their regulatory functional links unclear. Alterations in CRMP-2 expression that lead to its changes implicated Here, we investigate whether expression, possibly regulated by mTOR-related signaling,...
Spiraea prunifolia var. simpliciflora (SP) is traditionally used as an herbal remedy to treat fever, malaria, and emesis. This study aimed evaluate the anti-oxidative anti-inflammatory properties of methanol extract SP leaves in tumor necrosis factor (TNF)-α-stimulated NCI-H292 cells a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. decreased number inflammatory levels TNF-α, interleukin (IL)-1β, IL-6 bronchoalveolar lavage fluid, cell infiltration tissues SP-treated...
This study was conducted to investigate the impact of functional polymorphisms in FAS and FASL genes on survival early stage non-small cell lung cancer (NSCLC) patients.Three hundred thirty-eight consecutive patients with surgically resected NSCLC were enrolled. The -1377G>A (rs2234767) -670A>G (rs1800682) -844C>T (rs763110) investigated. Immunohistochemistry used assess protein expression tumors. genotype haplotype associations analyzed using Cox proportional hazards model, Kaplan-Meier...
A new compound, 9,10-dihydro-5-methoxy-8-methyl-2,7-phenanthrenediol (1), was isolated from the roots of Stemona tuberosa Lour. (Stemonaceae) together with two optically active compounds, (2S,4'R,8'R)-3,4-δ-dehydrotocopherol (2) and (2R,4'R,8'R)-3,4-δ-dehydrotocopherol (3). The structures compounds 1-3 were determined on basis spectroscopic data analysis. Compounds 2 3 each purified a stereoisomeric mixture by preparative HPLC using chiral column for first time. absolute configurations at...
Abstract Nucleotide excision repair (NER) reduces efficacy of treatment with platinum (Pt)-based chemotherapy by removing Pt lesions from DNA. Previous study has identified that missense mutation or loss the NER genes Excision Repair Cross Complementation Group 1 and 2 (ERCC1 ERCC2) leads to improved patient outcomes after Pt-based chemotherapies. Although most gene alterations found in tumors are mutations, impact mutations remaining nearly 20 is unknown. Towards this goal, we previously...