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Isabel Jerchel-Furau

ORCID: 0000-0003-1861-824X
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About
Contact & Profiles
A5003178394
Research Areas
  • Inflammatory mediators and NSAID effects
  • Eicosanoids and Hypertension Pharmacology
  • Peroxisome Proliferator-Activated Receptors

Molecular Oncology (United States)
 2022

Bayer (United States)
 2022

 Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists
OPENALEX - Publications 
Douglas L. Orsi Steven J. Ferrara Stephan Siegel Anders Friberg Léa Bouché and 16 more Elisabeth Pook Philip Lienau Joseph P. Bluck Christopher T. Lemke Gizem Akçay Timo Stellfeld Hanna Meyer Vera Pütter Simon J. Holton Daniel Korr Isabel Jerchel-Furau Constantia Pantelidou Craig A. Strathdee Matthew Meyerson Knut Eis Jonathan T. Goldstein

PPAR gamma (PPARG) is a ligand activated transcription factor that regulates genes involved in inflammation, bone biology, lipid homeostasis, as well master regulator of adipogenesis and potential lineage driver luminal bladder cancer. While PPARG agonists lead to transcriptional activation canonical target genes, inverse have the opposite effect through inducing transcriptionally repressive complex leading repression gene expression. many been described tested clinically, offer an...

10.1016/j.bmc.2022.117130 article EN cc-by-nc-nd Bioorganic & Medicinal Chemistry 2022-12-13
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