A5034576675- Inflammatory Bowel Disease
- Carcinogens and Genotoxicity Assessment
- Microscopic Colitis
- Animal testing and alternatives
- Effects and risks of endocrine disrupting chemicals
- Renal and related cancers
- Eosinophilic Esophagitis
- Pharmacogenetics and Drug Metabolism
- Pesticide Exposure and Toxicity
- Pregnancy and Medication Impact
- Arsenic contamination and mitigation
- Immunodeficiency and Autoimmune Disorders
- Toxic Organic Pollutants Impact
- Liver Diseases and Immunity
- Immunotoxicology and immune responses
- Renal cell carcinoma treatment
- Genomics, phytochemicals, and oxidative stress
- Water Treatment and Disinfection
- Chemical Analysis and Environmental Impact
- Pesticide and Herbicide Environmental Studies
- Agricultural safety and regulations
- Glutathione Transferases and Polymorphisms
- Biosimilars and Bioanalytical Methods
- Environmental Toxicology and Ecotoxicology
- Heavy Metal Exposure and Toxicity
Atlanta Gastroenterology Associates
2013-2025
Syngenta (United States)
2015-2024
Syngenta (United Kingdom)
2021
University of Regensburg
2018
Schneider Children's Medical Center
2018
Tel Aviv University
1991-2018
University of Bonn
2015
Environmental Protection Agency
2005-2014
Falun Hospital
2013
Research Triangle Park Foundation
2003-2012
Ozanimod (RPC1063) is an oral agonist of the sphingosine-1-phosphate receptor subtypes 1 and 5 that induces peripheral lymphocyte sequestration, potentially decreasing number activated lymphocytes circulating to gastrointestinal tract.
The need to develop new tools and increase capacity test pharmaceuticals other chemicals for potential adverse impacts on human health the environment is an active area of development. Much this activity was sparked by two reports from US National Research Council (NRC) Academies Sciences, Toxicity Testing in Twenty-first Century: A Vision a Strategy (2007) Science Decisions: Advancing Risk Assessment (2009), both which advocated "science-informed decision-making" field risk assessment....
Ozone has been proposed for water disinfection because it is more efficient than chlorine killing microbes and results in much lower levels of carcinogenic trihalomethanes does chlorination. leads to formation hypobromous acid surface waters with high bromine content forms brominated organic by-products bromate. The carcinogenicity chronic toxicity potassium bromate (KBrO 3 ) was studied male B6C3F 1 mice F344/N rats confirm extend the previous work. Mice were treated 0, 0.08, 0.4, or 0.8...
Triazole fungicides associated with a range of reported male reproductive effects in experimental animals were selected to assess potential toxic modes action. Wistar Han rats fed myclobutanil (M: 100, 500, or 2000 ppm), propiconazole (P: 2500 triadimefon (T: 1800 ppm) from gestation day 6 postnatal (PND) 120. One per litter was necropsied on PND1, 22, 50, 92. Measurements included anogenital distance (AGD) at PND0, body and organ weights, serum hormone levels, age preputial separation...
Health concerns have been raised because perfluorooctanoic acid (PFOA) is commonly found in the environment and can be detected humans. In rodents, PFOA a carcinogen developmental toxicant. peroxisome proliferator-activated receptor α (PPARα) activator; however, capable of inducing heptomegaly PPARα-null mouse. To study mechanism associated with toxicity, wild-type mice were orally dosed for 7 days (1 or 3 mg/kg) PPARα agonist Wy14,643 (50 mg/kg). Gene expression was evaluated using...
A rodent model of hereditary cancer in which a single gene mutation predisposes rats to bilateral multicentric renal cell carcinoma (RCC) is described. This rat syndrome shares certain similarities with von Hippel-Lindau disease (VHLD). In addition the early development epithelial tumors morphologic similarity human RCC, bear RCC are predisposed secondary primary cancers later life. Splenic vascular proliferative lesions, including hemangiosarcoma, were seen 23% 14-month-old both sexes that...
In support of an Organization for Economic Cooperation and Development (OECD) Amphibian Metamorphosis Assay (AMA) Test Guideline the detection substances that interact with hypothalamic-pituitary-thyroid axis, a document was developed provides standardized approach evaluating histology/histopathology thyroid glands in metamorphosing Xenopus laevis tadpoles. Here, consolidated description histology evaluation practices, core diagnostic criteria severity grading schemes AMA, atlas normal...
Perfluorooctanoic acid (PFOA) is a chemical used in the production of fluoropolymers. Its persistence environment and presence humans wildlife has raised health concerns. Liver tumor induction by PFOA thought to be mediated rodents PPAR-α. A recent US EPA scientific advisory board questioned contribution PPAR-α PFOA-induced liver tumors. response CD-1, SV/129 wild-type (WT), knockout (KO) mice was evaluated after seven daily treatments PFOA-NH 4 + (1, 3, or 10 mg/kg, p.o.) prototype...
The practice of toxicology is changing rapidly, as demonstrated by the response to 2007 NRC report on "Toxicity Testing in 21st Century." New assays are being developed replace animal testing; yet use data from these decision making not clear. A Health and Environmental Sciences Institute committee held a May 2011 workshop discuss approaches identifying adverse effects context report. Scientists industry, government, academia, NGOs discussed two case studies explored how information new,...
Classification schemes for carcinogenicity based solely on hazard-identification such as the IARC monograph process and UN system adopted in EU have become outmoded. They are a concept developed 1970s that chemicals could be divided into two classes: carcinogens non-carcinogens. Categorization this way places same category agents with widely differing potencies modes of action. This is how eating processed meat can fall sulfur mustard gas. Approaches hazard risk characterization present an...
Objective. To provide information on pregnancy outcomes in women receiving certolizumab pegol (CZP). Methods. The UCB Pharma safety database was searched for pregnancies through to September 1, 2014. Reports maternal and paternal CZP exposure were included examined, data exposure, pregnancy, comorbidities, infant events extracted by 2 independent reviewers. Concomitant medications disease activity reviewed clinical trial patients. Results. Of 625 reported pregnancies, 372 (59.5%) had known...
The US Environmental Protection Agency (USEPA) and other regulatory authorities have been working to utilize in vitro studies with human cells silico modelling reduce the use of vertebrate animals for evaluating chemical risk. Using Source-to-Outcome framework, a novel mathematical procedure was developed estimate equivalent concentration (HEC) inhalation risk assessment based upon relevant aerosol characterization, respiratory dosimetry modelling, endpoints derived from an assay using...