A5062257417- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Antibiotic Use and Resistance
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- Nosocomial Infections in ICU
- Microbial Inactivation Methods
- Nicotinic Acetylcholine Receptors Study
- Electromagnetic Fields and Biological Effects
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Single-cell and spatial transcriptomics
- Cytomegalovirus and herpesvirus research
- Sepsis Diagnosis and Treatment
Tel Aviv University
2021-2025
Atypical B cells represent an IFN-γ–driven cell lineage that may be similarly expanded in malaria, HIV, and autoimmunity.
Antimicrobial resistance is a rising global health threat, leading to ineffective treatments, increased mortality and healthcare costs. In ICUs, inappropriate empiric antibiotic therapy often given due treatment urgency, causing poor outcomes. This study developed machine learning model predict the appropriateness of antibiotics for ICU-acquired bloodstream infections, using data from MIMIC-III database. To address missing values dataset imbalances, novel computational methods were...
SUMMARY Multiple ongoing clinical trials use site-specific nucleases to disrupt T cell receptor (TCR) genes in order allow for allogeneic therapy 1–5 . In particular, the first U.S. trial using CRISPR-Cas9 entailed targeted disruption of TCR chains and programmed death protein 1 (PDCD1) cells refractory cancer patients 6 Here, we used same guide RNA sequences applied single-cell sequencing (scRNAseq) more than 7000 primary human cells, transfected with CRISPR-Cas9. Four days...
Abstract Unleashing cytotoxic CD8 + T cells for effective cancer treatment requires understanding cell states across different tumor microenvironments. Here, we developed an algorithm to recover both shared and type specific programs used it analyze a scRNA-seq compendium of 38,852 from 141 patients spanning nine human cancers. We uncovered pan-cancer dysfunction program that was predictive clinical responses immunotherapy highlighted CXCR6 as marker dysfunctional cells. In mouse models,...
<h3>Background</h3> Pulsed Electric Field (PEF) ablation kills cells via non-thermal processes, offering improved safety and distinct immunomodulatory effects versus Radiofrequency (RFA) thermal ablation. A proprietary PEF system with an optimized immunostimulatory waveform was modified for murine treatments previously shown to induce local systemic anti-tumor immunity in conjunction aPD-1.<sup>1–3</sup> This study compares the immune responses stimulated by this RFA, particularly regarding...
Abstract Antimicrobial resistance is a growing threat to global health, leading ineffective treatment of infection and increasing failure, mortality, healthcare costs. Inappropriate antibiotic therapy often administered in the Intensive Care Unit (ICU) due urgency treatment, but can lead poor patient outcomes. In this study, we developed machine learning model that predicts appropriateness treatments for ICU inpatients with ICU-acquired blood infection. We analyzed data from electronic...