A5008083510- Prostate Cancer Treatment and Research
- Acute Lymphoblastic Leukemia research
- Bladder and Urothelial Cancer Treatments
- Acute Myeloid Leukemia Research
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Urologic and reproductive health conditions
- Platelet Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer-related gene regulation
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Epigenetics and DNA Methylation
- Blood groups and transfusion
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Neutropenia and Cancer Infections
- RNA modifications and cancer
- Genital Health and Disease
- Polyomavirus and related diseases
- Chronic Myeloid Leukemia Treatments
- Blood disorders and treatments
- CAR-T cell therapy research
Wuhan University
2025
Baoji City Central Hospital
2021-2025
First Affiliated Hospital of Xi'an Jiaotong University
2020-2025
Ningbo Institute of Industrial Technology
2025
Chinese Academy of Sciences
2025
Renmin Hospital of Wuhan University
2025
Soochow University
2013-2024
First Affiliated Hospital of Soochow University
2018
Beijing Friendship Hospital
2013
Capital Medical University
2013
Abstract Prostate cancer (PCa) is one of the most common malignancy in men. However, molecular mechanism its pathogenesis has not yet been elucidated. In this study, we demonstrated that CYLD, a novel deubiquitinating enzyme, impeded PCa development and progression via tumor suppression. First, found CYLD was downregulated tissues, expression inversely correlated with pathological grade clinical stage. Moreover, discovered inhibited cell proliferation enhanced sensitivity to ferroptosis...
Cytoreductive radical prostatectomy (cRP) has emerged as a promising therapeutic approach for low-volume metastatic hormone-sensitive prostate cancer (mHSPC), but the best candidates cRP are still unknown. This study aims to explore potential value of 18F-PSMA-1007 PET/CT-derived quantitative volumetric tumor parameters in treatment selection among patients with mHSPC. A total 122 primary mHSPC who underwent PET/CT followed by systemic therapy alone or plus were included. The whole-body...
pH-Sensitive oligopeptide magnetic mesoporous silica beads were successfully prepared by using large-pore dendritic colloids as templates for DNA extraction.
4008 Background: In Asia, where hepatitis B is very common, hepatocellular carcinoma (HCC) the third most common cancer. Asian patients often present with locally advanced or metastatic HCC, which are not eligible for surgery localized treatments – median survival only 3 months supportive care. Systemic chemotherapies commonly used but there no evidence of a benefit. Oxaliplatin-containing regimens have shown efficacy against HCC in several phase II trials. Methods: This open-label,...
The objective of this study was to observe the prognosis pediatric patients with E2A-PBX1-positive acute lymphoblastic leukemia (ALL) from treatment CCLG-ALL2008 protocol.Three hundred and forty-nine Chinese pre-B-cell ALL were enrolled in December 2008 September 2013. Of these, 20 E2A-PBX1 expression 223 without gene stratified into two cohorts. Clinical biological characteristics 5-year event-free survival (EFS), relapse-free (RFS), overall (OS) analyzed compared between these groups.The...
Autoimmune hemolytic anemia (AIHA) is a rare disease in children, and its clinical severity varies. To better understand manifestation treatment outcome, we analyzed 68 children diagnosed as AIHA for characteristics, laboratory findings, outcomes. Data show that primary accounted 39.7% of all patients, whereas secondary 60.3%. Among them, Evans syndrome (ES) 20 cases (29.4%). Average hemoglobin was lower the 1-year or below age group than above group, combined-antibody single-antibody...
Despite the use of targeted therapeutic approaches, T-cell acute lymphoblastic leukemia (T-ALL) is still associated with a high incidence complications and poor prognosis. Indisulam (also known as E7070), newly identified molecular glue compound, has demonstrated increased efficacy in several types cancer through rapid degradation RBM39. This study aimed to evaluate potential indisulam T-ALL, elucidate its underlying mechanisms explore role RBM39 gene. We verified anticancer effects both...
Metastases from prostate cancer (PCa) to the penis are extremely rare, and few case reports exist in literature. Because most patients usually present with multiple distant metastases at diagnosis, prognosis is very poor. With wide application of prostate-specific membrane antigen (PSMA) PET/CT, penile may be detected an early stage. Thus, questions regarding whether diagnosis precise treatment will equate a survival advantage have recently been raised. In study, we reported 3 cases...
Zinner’s syndrome (ZS) is a rare congenital malformation due to abnormal development of the urogenital tract. It characterized by triad unilateral renal agenesis, ipsilateral seminal vesicle cyst and ejaculatory duct obstruction. Cases are rarely reported in China since incidence disease low. Symptoms also vary widely among patients its etiology unclear. In this article, we described two with totally different cinicopathological genetic features based on exon sequencing.
To assess the rate and location of residual tumor in re-transurethral resection bladder (re-TURBT) develop a risk stratification tool to assist clinicians making treatment decisions.The data 144 patients with high-risk cancer who received re-TURBT were retrospectively reviewed. The tumors was recorded. Logistic regression performed explore factors for tumors, classification developed.Among patients, rates at base primary 22.2% 10.4%, respectively. Non-urothelial carcinoma subspecialist,...
Prostate-specific antigen nadir (nPSA) and time to nPSA (TTN) have been proved be associated with the prognosis of prostate cancer. In this study, we explored effect TTN during initial androgen deprivation therapy (ADT) in patients metastatic castration-resistant cancer (mCRPC) after treatment docetaxel-based chemotherapy. The data 153 mCRPC received docetaxel followed by ADT were retrospectively reviewed. Multivariate Cox regression analysis demonstrated that (overall survival (OS): Hazard...
Signal pathways mediated by epidermal growth factor receptor (EGFR) and E-series of prostaglandin receptors (EPs) are closely correlated to the pathogenesis tumor. This experiment was designed investigate expression clinical significance EP2 EGFR in esophageal squamous cell carcinoma (ESCC). Tissue samples were collected reterospectively from 87 patients with ESCC (first diagnosed). The followed up for 5 years after radical surgery. EP-2 examined tissue chip technology immunohistochemistry...
Prostate lymphoma (PL) is rarely observed and may be concurrently presented with prostate adenocarcinoma. Moreover, the appearance of PL on conventional imaging similar Thus, most diagnosed through biopsy, or accidentally found in specimens surgery. Prostate-specific membrane antigen (PSMA) PET/CT has improved management While, question regarding whether it benefits discovery characteristics unknown. A 32-year-old man worsening dysuria for 1 month, prostate-specific (PSA) concentration was...
Abstract Background Relapse is the major reason for death in pediatric acute lymphoblastic leukemia (ALL) patients. It may be worse because of refusing re-treatment developing countries. So, we investigated influencing factors decision made by parents and survival data patients with relapsed ALL China. Methods Clinical characteristics, choice re-treatment, status at last follow-up time were collected, prognostic analyzed. Results Among 390 cases which collected from five centers China, 230...