Aim: to assess the fat depot compartments and some cardiometabolic risk markers in patients with chronic heart failure preserved ejection fraction (CHFpEF), prediabetes abdominal obesity. Patients Methods: this randomized open single-center study was carried out Research Institute for Therapy Preventive Medicine — Branch of Federal Center Cytology Genetics Siberian RAS included 64 subjects (32 them were males) CHFpEF, The standard general clinical examination laboratory tests, measurements...

The current state of the Russian and foreign regulatory framework for off-label prescription medicines is presented in article. existing problems this specific drug therapy possible solutions are described. Unfortunately, there some gaps legislation regarding medication use. Based on clinical reality, cases, “off-label” drugs can be justified by condition patient, lack alternative approved drugs, availability published scientific data that create prerequisites effectiveness approach. When...

Научно-исследовательский институт терапии и профилактической медицины

Considering the increasing amount of elderly people in Russia and world, an active study arterial hypertension this group is actual clinically demanded task. The strategic direction defining treatment tactic such patients, especially over 80 years old, determination their functional status presence frailty syndrome, which not synonymous with comorbidity obligatory early aging companion, but specifies need for a personalized approach hypertension, even complete abolition antihypertensive...

Insulin resistance, which is a fundamental pathogenetic factor of prediabetes, closely associated with abdominal obesity on the one hand and development cardiovascular diseases, heart failure (HF), other. The role insulin resistance multifaceted consists in acceleration atherosclerosis, formation left ventricular myocardial hypertrophy, including through mechanisms that do not depend blood pressure, as well its diastolic dysfunction. latter starting point for HF preserved ejection fraction...

Acute pancreatitis is one of the most common gastrointestinal causes for hospitalization after acute appendicitis. Despite recent advances in treatment methods, mortality from and its complications remains high. Hypertriglyceridemia an underestimated cause pancreatitis, accounting 10% among other etiological factors. Timely diagnosis hypertriglyceridemia, a personalized approach, selection adequate lipid-lowering therapy allow reducing risk developing and/or preventing recurrent...

Chronic heart failure is a global cardiac problem. The last decade can rightly be called breakthrough in the treatment of this nosology, due to emergence new group drugs – SGLT2 inhibitors (gliflozins), which, both patients with initial different ejection fraction, and presence risk factors for its development, have persistent positive impact on number hospitalizations failure. A pleiotropic effects are also attractive clinician, which include moderate weight loss, decrease body fat visceral...

The article presents step by international CARE guidelines (CAse REport), which regulate the structure of description a clinical case and include checklist 13 points. This form presentation material does not create any difficulties in understanding, require long period time to prepare publication for author, demonstrating unique personalized experience informing medical community about interesting manifestations, diagnostic or therapeutic approaches within particular nosology, as well...

Background. The problem of urinary tract infections, including recurrent cystitis, and the choice effective safe means treatment prevention, taking into account increasing burden antibiotic resistance, are extremely relevant. Aim. To evaluate effectiveness safety herbal medicine Canephron® N for prevention exacerbations cystitis its effect on metabolic parameters in patients with type 2 diabetes mellitus sodium glucose cotransporter inhibitors. Material methods. A prospective, randomized,...

Aim. To study the effect of extended-release (XR) metformin on humoral cardiometabolic markers and lipid peroxidation parameters in patients with heart failure preserved ejection fraction (HFpEF), prediabetes abdominal obesity (AO). Material methods. The included 64 people (men – 50%, median age 58 [55,25; 59,75] years) HFpEF, AO. All (groups A B) received optimal therapy for HFpEF. In group (n=32), XR 1000-1500 mg/day was additionally prescribed. general clinical examination carried out,...

BACKGROUND : Considering the role of visceral adipose tissue deposition in pathogenesis heart failure with preserved ejection fraction (HFpEF) and positive effect metformin on weight loss, this drug compartments patients HFpEF is interest. AIM: To study extended-release (XR) various fat depots parameters insulin-glucose homeostasis HFpEF, prediabetes abdominal obesity (AO). MATERIALS AND METHODS Study design: single-center, open-ended, randomized, prospective, controlled. The registration...

Introduction . Chronic heart failure with preserved ejection fraction (CHpEF) is a heterogeneous syndrome variety of pathophysiological factors, including obesity and impaired carbohydrate metabolism associated an increase in visceral adipose tissue. Due to the positive effect metformin on weight loss, recent years special attention has been paid its fat depots. Aim To study effects XR after 12 months administration various depots glucose parameters patients CHpEF, prediabetes abdominal...

Клинический случай в практике врачаинтерниста: пациентка с высокой скоростью оседания эритроцитов Батлук Т. И. 1 м.н.с.лаборатория профилактической медицины Цыганкова О.В.1,2 д.м.н., научный сотрудник, лаборатория клинических, биохимических и гормональных исследований терапевтических заболеваний : доцент, кафедра неотложной терапии эндокринологией профпатологией ФПК ППВ 2 Латынцева Л. Д. к.м.н., заслуженный врач РФ, заведующая, терапевтическое отделение клиники НИИТПМ, старший сотрудник лаборатории

Understanding the molecular mechanisms of atherosclerotic vascular lesions formation is necessary both for assessing risks cardiovascular diseases and finding approaches to their therapy. The task remains relevant, despite large number studies carried out, because there are differences in factors genetic predisposition atherosclerosis its complications between different ethno-territorial groups. aim this study was search variants pattern recognition receptors associated with lipid metabolism...

Aim of the study was to investigate main components lipid spectrum blood serum in patients with coronary artery disease, depending on level estradiol (E2), testosterone (T) and age. Material methods . We examined 161 men aged 35–65 years (median [lower quartile; upper quartile] 53.1 [40.1; 59.4] years) a history myocardial infarction more than 30 days before inclusion study. Patients were divided into groups by age (35–55 56–65 years), as well according content sex hormones: T ≥ 12 nmol/l...

ЦЕЛЬ: изучение компартментов жировых депо и некоторых кардиометаболических гуморальных марке-
 ров у пациентов с хронической сердечной недостаточностью сохраненной фракцией выброса (ХСНсФВ),
 предиабетом абдоминальным ожирением.
 МАТЕРИАЛЫ И МЕТОДЫ: в интервенционное одноцентровое открытое рандомизированное про-
 спективное контролируемое исследование на базе НИИ терапии профилактической медицины филиала
 ИЦиГ СО РАН (г. Новосибирск) включено 64 человека (из них 32 –...

The clinical case of the successful use myocardial cytoprotector trimetazidine as a universal anti-ischemic agent in patient with hemodynamic angina due to bridging is described. pathogenetic rationale for this prescription presented.