A5037320615- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Sepsis Diagnosis and Treatment
- Nutrition and Health in Aging
- Pharmacological Effects and Toxicity Studies
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Frailty in Older Adults
- Epilepsy research and treatment
- Mosquito-borne diseases and control
- Electrolyte and hormonal disorders
- Shoulder Injury and Treatment
- Hematological disorders and diagnostics
- Liver Disease and Transplantation
- Infectious Diseases and Tuberculosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Pesticide Exposure and Toxicity
- Inflammatory Biomarkers in Disease Prognosis
- Renal function and acid-base balance
- Vitamin D Research Studies
- Systemic Lupus Erythematosus Research
- Colorectal Cancer Treatments and Studies
Jawaharlal Nehru Medical College Hospital
2017-2025
Subharti Medical College
2021-2025
Datta Meghe Institute of Medical Sciences
2009-2025
Jawaharlal Nehru Medical College
2016-2025
New York Medical College
2025
Jawaharlal Nehru Medical College
2018-2024
Jawaharlal Institute of Post Graduate Medical Education and Research
2024
Pt. Jawahar Lal Nehru Memorial Medical College
2024
National University of Singapore
2024
Center for Rheumatology
2024
Nivolumab is a fully human monoclonal antibody that inhibits programmed death-1 activation. The clinical pharmacology profile of nivolumab was analyzed by population pharmacokinetics model assessed covariate effects on concentrations in 1,895 patients who received 0.3–10.0 mg/kg 11 trials. linear with time-varying clearance. A full developed to assess pharmacokinetic parameters. clearance and volume distribution increase body weight. final included the baseline performance status (PS),...
Nivolumab 3 mg/kg every 2 weeks (Q2W) has shown benefit versus the standard of care in melanoma, non-small cell lung cancer (NSCLC), and renal carcinoma (RCC). However, flat dosing is expected to shorten preparation time improve ease administration. With knowledge nivolumab safety, efficacy, pharmacokinetics across a wide dose range body weight (BW) dosing, assessment benefit-risk profile 240-mg relative approved 3-mg/kg was approached by quantitative clinical pharmacology.A 240 mg selected...
A nivolumab monotherapy flat-dosing regimen of 480 mg every 4 weeks (Q4W) has been approved in several markets, including the United States, Canada, and European Union, as an alternative dosing for indications. Approvals this Q4W were based on population pharmacokinetic (PK) analyses, established flat exposure-response relationships, clinical safety. The objective study was to compare PK exposure with 3 mg/kg 2 (Q2W) 240 Q2W using modeling simulation, evaluate safety regimen.Nivolumab...
Nivolumab 480 mg every 4 weeks (Q4W) is approved in the European Union, United States, and several other markets across multiple tumor types. Its approval was supported by quantitative efficacy/safety analyses bridging to 3 mg/kg 2 (Q2W).The benefit-risk profile of nivolumab Q4W relative Q2W evaluated using population pharmacokinetic modeling exposure-response (E-R) for safety efficacy. Pharmacokinetic exposures were predicted 3203 patients with melanoma, non-small-cell lung cancer (NSCLC),...
To inform the benefit-risk assessment of nivolumab in patients with advanced melanoma, analyses efficacy and safety exposure-response (E-R) relationships were conducted data from melanoma enrolled two clinical studies (phase I phase III) who received 0.1-10.0 mg/kg every 2 weeks. E-R performed by relating time-averaged concentration after first dose (C
Chronic obstructive pulmonary disease (COPD) patients experience a progressive deterioration and disability leading to worsening of their health-related quality life (HRQoL) functional exercise capacity. We performed this study identify the correlation HRQoL assessed by St George's Respiratory Questionnaire (SGRQ) capacity six-minute walk test (6MWT) with severity COPD defined Global Initiative for Obstructive Lung Disease (GOLD) criteria among spirometry-confirmed patients, admitted in...
3590 Background: Dasatinib is 325-fold more potent than imatinib and 16-fold nilotinib against BCR-ABL in vitro. In the randomized, dose optimization Study CA180–034 of pts with chronic phase CML, 100 mg once daily was associated similar efficacy but less frequent pleural effusion (pl eff), cytopenia, reduction, interruption other three dosing schedules. Methods: The clinical study design has been previously described. Here we present population pharmacokinetic (PPK) E-R analyses. Exposure...
The anemia not only negatively affects physical function but also the cognition, mood, and quality of life in adult patients due to hypoxic condition as per its severity. This study has been planned investigate cross-section association with cognitive neurologically intact patients.In this study, a total 200 subjects were enrolled out which 100 cases age sex matched controls. Mini-mental status examination (MMSE) short portable mental questionnaire (SPMSQ) scales used assess cognition all...
Background The high prevalence of thyroid dysfunction in patients with chronic kidney disease (CKD) indicates a major correlation between the progression CKD and dysfunction. In this study, we highlighted its relation to severity different stages CKDs. Materials methods From October 2018 September 2020, 200 cases CKD, admitted under Department Medicine at rural teaching hospital central India, were selected for study. collected data was analyzed correlated using Chi-square test, parameters...
Palliative bundle effectivity in cancer care - AGEMS- Print ISSN No: 2348-7348 Online No:- 2348-7240 Article DOI 10.18231/j.agems.2024.008, Annals of Geriatric Education and Medical Sciences-Ann Geriatr Educ Med Sci
Urolithiasis is a common disease, to which the general population at risk. It causes physical and financial stress on patients. also increased load already burdened medical facilities especially in developing countries. Knowledge of chemical composition stones before surgical intervention can help most efficient management disease decreasing burden both patients facilities. Seventy five subjects diagnosed with urolithiasis were pre operatively assessed for NCCT KUB, IVP, Urinalysis compared...
Introduction This study examined acute febrile illness (AFI) patients for several epidemiological and etiological factors. Acute fever can result from various illnesses, including dengue, malaria, leptospirosis, scrub typhus. The ranges of clinical outcomes these cases were investigated as well. Methods retrospective observational was conducted January 2023 to 2024 one year in the Medicine Department Jawaharlal Nehru Medical College Acharya Vinoba Bhave Rural Hospital, Datta Meghe Institute...
Although brain has been the most common site for toxoplasma infection in acquired immunodeficiency syndrome patients, involvement of spinal cord by rarely found. Spinal toxoplasmosis can present as acute onset weakness both lower limbs associated with sensory and bladder dysfunction. A presumptive diagnosis be made patients CD4 count <100/mm 3 based on a positive serum Toxoplasma gondii IgG antibodies, no recent prophylaxis against toxoplasmosis, intramedullary ring enhancing lesion...
Introduction: Pre-diabetes is a state of intermediate hyperglycemia. Although it looks benign, pre-diabetes known to be associated with low-grade inflammation. High sensitivity C-reactive protein (hsCRP) sensitive marker detect Here, we studied whether hsCRP can used as biomarker in the early diagnosis rural population. Methods: A total 200 participants, including 100 cases and controls who were age- gender-matched, enrolled according World Health Organisation criteria for this study. All...
Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count simple and inexpensive test, elevated associated with acute inflammation increased oxidative stress-like OPP. This study was done to correlate the severity of OPP leukocyte also assess prognosis.A prospective, observational clinical on 80 patients suspected age >15 years admitted emergency unit at tertiary rural teaching health-care center Central Serum cholinesterase level...
Magnesium deficiency has been a common, but easily ignored, electrolyte abnormality. Studies on magnesium are lacking in India, especially rural setting. Here, we have correlated serum levels with outcomes elderly patients admitted to the medical intensive care unit respect length of stay, need for mechanical ventilatory support and its duration, outcome (discharge/death). A prospective, observational study was conducted aged 60 years older, who had medicine department over year. The...
AbstractAbstractBackground: Telemedicine has been increasingly used as an option for acute ischemic stroke treatment at hospitals where neurological expertise is not available. The aim of this study was to compare the outcome patients treated with systemic thrombolysis our academic hub regional centers (hub) versus spoke hospital telemedicine locations (spoke). Methods: Data were retrospectively reviewed consecutive admitted intravenous tissue plasminogen activator (128 patients) and (27...