A5049915140- Vagus Nerve Stimulation Research
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Pancreatic function and diabetes
- Neuroscience and Neural Engineering
- Click Chemistry and Applications
- Gut microbiota and health
- Chemistry and Chemical Engineering
- Wound Healing and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Thyroid Disorders and Treatments
- Hydrogen Storage and Materials
- Adrenal Hormones and Disorders
- Magnesium Alloys: Properties and Applications
- Urologic and reproductive health conditions
- Neurological disorders and treatments
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Aluminum Alloys Composites Properties
- Pleural and Pulmonary Diseases
- Silk-based biomaterials and applications
- Testicular diseases and treatments
- Computational Drug Discovery Methods
University of Toledo
2022-2024
University of Florida
2015-2023
University of Cincinnati
2015
University of Tübingen
2000
Klinikum rechts der Isar
1991
Wound care is one of the leading health problems in United States costing billions dollars yearly. Annually, millions acute wounds occur due to surgical procedures or traumas such as burns and abrasions, these can become non-healing bacterial infection underlying pathologies. Current wound treatments include use bioinert constructs combined with topical administration anti-bacterial agents growth factors. However, there a growing need for development bioactive dressing materials that are...
Biodegradable Mg alloys have the potential to replace currently used metallic medical implant devices, likely eliminating toxicity concerns and need for secondary surgeries, while also providing a potentially stimulating environment tissue growth. A recently developed Mg-Ca-Sr alloy possesses advantageous characteristics over other alloys, having good combination of strength degradation behavior, displaying osteogenic properties. To better understand effect products on cellular mechanisms,...
Hypertension is a pervasive global health challenge, impacting over billion individuals worldwide. Despite strides in therapeutic strategies, significant proportion of patients remain resistant to the currently available therapies. While conventional treatments predominantly focus on cardiac, renal, and cerebral targets, emerging research underscores pivotal role gut its microbiota. Yet, precise mechanisms governing interactions between microbiota host blood pressure unclear. Here we...
Augmented vagal signaling may be therapeutic in hypertension. Most studies to date have used stimulation of the cervical branches. Here, we investigated effects chronic intermittent electric ventral subdiaphragmatic nerve branch (sdVNS) on long-term blood pressure, immune markers, and gut microbiota spontaneously hypertensive rat (SHR), a rodent model hypertension characterized by dysfunction, dysbiosis, low-grade inflammation. We evaluated sdVNS transcriptional networks nucleus solitary...
During type 1 diabetes, an autoimmune attack destroys pancreatic β-cells leading to the inability maintain glucose homeostasis. These are neuroresponsive endocrine cells which normally secrete insulin partially in response input from vagus nerve. This neural pathway can be utilized as a point of therapeutic intervention by delivering exogenous stimulation drive increased secretion. In this study, cuff electrode was implanted on branch nerve just prior insertion rats, and continuous meter...
The negative effects of space flight on cardiovascular health astronauts have been demonstrated and documented over many years. Endothelial cells (ECs) play an important role in regulating weightlessness-induced dysfunction. This project seeks to study the effect microgravity differentiation endothelial progenitor (EPCs) into ECs downstream functions differentiated cells. Initial exposure EPCs indicated inhibition migratory, proliferative, antithrombogenic capacity ECs. However, our results...
In this study, we acutely identified a target branch of the vagus nerve known as pancreatic nerve, which exclusively innervates pancreas by applying electrical stimulus to cervical and observing compound neural action potentials at nerve. set chronically implanted rats, was again cuffed using an electrode also with continuous glucose monitor. A model type 1 diabetes (T1D) chemically induced hyperglycemic state confirmed. After induction, stimulation applied heart rate variability measured...
Introduction: The vagus facilitates a bidirectional gut-brain communication. Low vagal tone is shown in conditions marked by inflammation and dysbiosis, including hypertension (HTN). However, the role of gut-projecting nerve branches blood pressure (BP) control unexplored. Supplementing potentially impaired gut using electrical stimulation (vns) may restore homeostasis microbiota-gut-brain axis HTN. Methods: Male 8 week-old Wistar-Kyoto (WKY, N=6) spontaneously hypertensive rats (SHR, N=10)...
Introduction The gut‐brain vagal axis, of which serotonin (5HT) is an important mediator, can be altered by the gut microbiota. Low tone and autonomic imbalance present in conditions marked dysbiosis including hypertension (HTN); however, effect on sensory/afferent function HTN unknown. We hypothesized that HTN‐associated will decrease serotonergic afferent signaling from cause leading to increased blood pressure (BP). Moreover, we propose restoring axis chronic stimulation alleviate HTN....
Neuromodulation can be used to control organ function through exogenous augmentation of neural activity via targeted delivery an electrical stimulus. Recently, neuromodulation has been a topic investigation treat many illnesses and conditions including Parkinson’s disease, epilepsy, obesity, chronic pain, type 1 diabetes, hypertension. During neuromodulatory treatments, it is important measure both the physiological response target system as well any off-target systems that may engaged from...
The vagus nerve facilitates bidirectional communication between the gut and brain. A low vagal tone has been described in many conditions characterized by inflammation dysbiosis, including hypertension (HTN). While linked with clinical observations, mechanisms of gut-brain are not fully understood. Moreover, role sub-diaphragmatic gut-projecting branches control blood pressure (BP) remains unclear. objective this study was to examine systemic central effects augmenting activity using...