A5008008876- Plant Water Relations and Carbon Dynamics
- Remote Sensing in Agriculture
- Greenhouse Technology and Climate Control
- Horticultural and Viticultural Research
- Remote Sensing and LiDAR Applications
- Plant responses to elevated CO2
- Leaf Properties and Growth Measurement
- Smart Agriculture and AI
- Trypanosoma species research and implications
- Aeolian processes and effects
- Wind and Air Flow Studies
- Meteorological Phenomena and Simulations
- Urban Heat Island Mitigation
- Forest ecology and management
- Research on Leishmaniasis Studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Tree Root and Stability Studies
- Fluid Dynamics and Turbulent Flows
- Synthesis and Biological Evaluation
- Fire effects on ecosystems
- Biochemical and Molecular Research
- Building Energy and Comfort Optimization
- Synthesis and biological activity
- Hydrology and Sediment Transport Processes
- Tribology and Lubrication Engineering
University of California, Davis
2017-2025
Plant (United States)
2023-2024
University of Utah
2011-2017
Horticultural Crops Research Laboratory
2017
Agricultural Research Service
2014-2016
United States Department of Agriculture
2014-2016
University of Illinois Urbana-Champaign
1999-2002
University of Buenos Aires
2000-2002
Hungarian Academy of Sciences
2002
Fundación Ciencias Exactas y Naturales
2000-2001
We have investigated the effects in vitro of a series bisphosphonates on proliferation Trypanosoma cruzi, brucei rhodesiense, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum. The results show that nitrogen-containing type used bone resorption therapy significant activity against parasites, with aromatic species having some cases nanomolar or low-micromolar IC50 values parasite replication (e.g. o-risedronate, = 220 nM for T. rhodesiense; risedronate, 490 gondii). In...
As a continuation of our project aimed at the search for new and safe chemotherapeutic chemoprophylactic agents against American trypanosomiasis (Chagas' disease), several drugs structurally related to 4-phenoxyphenoxyethyl thiocyanate (4) were designed, synthesized, evaluated as antiproliferative parasite responsible this disease, hemoflagellated protozoan Trypanosoma cruzi. This derivative was previously shown be an effective potent agent T. cruzi proliferation. Several possessing groups...
High field <sup>31</sup>P nuclear magnetic resonance spectroscopy showed that inorganic pyrophosphate (P<sub>2</sub>O<sub>7</sub><sup>4−</sup>) is more abundant than ATP in <i>Trypanosoma cruzi</i>, the causative agents of Chagas' disease. These results were confirmed by specific analytical assays, which epimastigotes, concentrations and 194.7 ± 25.9 37.6 5.5 nmol/mg protein, respectively, for amastigote form, corresponding 358.0 17.0 36.0 1.9 protein. performance liquid chromatographic...
We report the cloning and sequencing of a gene encoding farnesyl pyrophosphate synthase <i>Trypanosoma cruzi</i>. The protein (<i>T. cruzi</i> synthase, TcFPPS) is an attractive target for drug development, since growth <i>T. inhibited by carbocation transition state/reactive intermediate analogs its substrates, nitrogen-containing bisphosphonates currently in use bone resorption therapy. predicted from nucleotide sequence has 362 amino acids molecular mass 41.2 kDa. Several motifs found...
In this paper we used simulation tools to study turbulent boundary-layer structures in the roughness sublayer. Of particular interest is case of a neutrally-stratified atmospheric boundary layer which lower covered by homogeneous plant canopy. The goal was formulate consistent conceptual model for creation and evolution dominant coherent associated with canopy how they link features observed overlying inertial First, were examined using temporally developing flow where full range scales had...
This article presents an overview of Helios, a new three-dimensional (3D) plant and environmental modeling framework. Helios is model coupling framework designed to provide maximum flexibility in integrating running arbitrary 3D system models. Users interact with through well-documented open-source C++ API. Version 1.0 comes plug-ins for radiation transport, the surface energy balance, stomatal conductance, photosynthesis, solar position, procedural tree generation. Additional are also...
The addition of PPi promoted the acidification a subcellular compartment in cell homogenates Toxoplasma gondii tachyzoites, implying presence proton-translocating pyrophosphatase. proton gradient was collapsed by K+/H+ antiporter nigericin, and also inhibited analogue aminomethylenediphosphonate (AMDP). Both transport hydrolysis were dependent upon K+, but Na+ caused partial inhibition these activities. sensitive dose-dependent manner to AMDP, imidodiphosphate, NaF thiol reagent...
The effects in vivo of the bisphosphonate drug pamidronate, used bone resorption therapy, were investigated an experimental model cutaneous leishmaniasis. Pamidronate at intraperitoneal dose 10 mg/kg/day for 5 days a radical cure leishmaniasis Balb/c mice, as evidenced by long-term disappearance lesions; amastigotes lesion sites, determined histopathological analysis and cultivation material obtained from polymerase chain reaction necropsy material, using probes specific kinetoplast DNA. is,...
As a part of our project directed at the search new chemotherapeutic agents against American trypanosomiasis (Chagas' disease), several drugs possessing 4-phenoxyphenoxy skeleton and other closely related structures employing thiocyanate moiety as polar end group were designed, synthesized, evaluated antiproliferative Trypanosoma cruzi, parasite responsible for this disease. These analogues envisioned bearing in mind potent activity shown by 4-phenoxyphenoxyethyl (compound 8) taken lead...
A microscale wildfire model, QES-Fire, that dynamically couples the fire front to winds was developed using a simplified physics rate of spread (ROS) kinematic plume-rise model and mass-consistent wind solver. The is three-dimensional heat fluxes field while being more computationally efficient than other coupled models. calculates potential velocity scaled by ROS model’s flux. Distinct plumes are merged multiscale plume-merging methodology can efficiently represent complex fronts. plume...
Stomatal conductance ( g s ) is a crucial component of plant physiology, as it links productivity and water loss through transpiration. Estimating indirectly leaf temperature T l measurement common for reducing the high labor cost associated with direct measurement. However, relationship between observed can be notably affected by local environmental conditions, canopy structure, scale, sample size, itself. To better understand quantify variation in measurements to , this study analyzed...
Deep learning and multimodal remote proximal sensing are widely used for analyzing plant crop traits, but many of these deep models supervised necessitate reference datasets with image annotations. Acquiring often demands experiments that both labor-intensive time-consuming. Furthermore, extracting traits from data beyond simple geometric features remains a challenge. To address challenges, we proposed radiative transfer modeling framework based on the Helios 3-dimensional (3D) software...
Advancements in artificial intelligence (AI) have greatly benefited plant phenotyping and predictive modeling. However, unrealized opportunities exist leveraging AI advancements model parameter optimization for fitting complex biophysical models. This work developed novel software, PhoTorch, parameters of the Farquhar, von Caemmerer, Berry (FvCB) biochemical photosynthesis based components popular framework PyTorch. The primary novelty software lies its computational efficiency, robustness...