A5058202099- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Prenatal Substance Exposure Effects
- Homelessness and Social Issues
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Nuclear Receptors and Signaling
- Endoplasmic Reticulum Stress and Disease
- Viral Infections and Outbreaks Research
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Organ Transplantation Techniques and Outcomes
- Microscopic Colitis
- Viral Infections and Vectors
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Hepatitis Viruses Studies and Epidemiology
Penn State Milton S. Hershey Medical Center
2014-2024
Pennsylvania State University
2013-2024
Central South University
2010-2024
Binzhou Medical University
2024
Xiangya Hospital Central South University
2010-2024
Central Hospital of Zibo
2024
Dalian Medical University
2019-2023
Chongqing Medical University
2019-2023
Second Affiliated Hospital of Chongqing Medical University
2019-2023
Shandong Agricultural University
2023
Background: The antimicrobials resistance of Helicobacter pylori (H. pylori) was able to sharply decline the eradication rate H. both in adults and children, but there are limited studies about primary antibiotic related gene mutations, specifically China. Materials Methods: 9 antibiotics 73 strains isolated from gastric biopsies children recruited at Beijing Children's Hospital assessed, mutations 23S rRNA 65 macrolide-resistant gyrA gyrB 12 quinolone-resistant were investigated. Results:...
Although HPV vaccination has been recommended for use in girls and young women since 2007, vaccine uptake is low the US. We conducted a retrospective cohort study using 2008–2011 MarketScan data to examine completion dose adherence among commercially insured females aged 9–26 years. performed multivariable logistic regression models factors related adherence. Among 378,484 years who initiated vaccination, only 29.4% completed vaccination. Compared with receiving vaccines from primary care...
The roles of M2 macrophages on promoting tumor progression and chemotherapy resistance have been well studied in many cancers, such as pancreatic cancer, kidney cancer so on, but its linkage to HCC cells still remains unclear. Here we found that could alter miR-149-5p increase MMP9 expression mechanism dissection revealed might directly target the 3'UTR MMP9-mRNA suppress translation. vivo orthotopic xenografts mouse model with oemiR-149-5p also validated vitro data. Together, these findings...
Antidepressant medications (AMs) are frequently used in inflammatory bowel disease (IBD). Many AMs enhance serotonin (5-HT) availability, but this phenomenon may actually worsen IBD. We hypothesized that use of 5-HT-enhancing would be associated with poor clinical outcomes these disorders. performed a retrospective cohort study using the Merative Health Marketscan® commercial claims database between 1/1/05 and 12/31/14. Participants (18-63 years) were either controls or had ≥ 2 ICD-9...
The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem and novel therapeutic strategies are required to prevent treat T2DM. It has been demonstrated that resveratrol (RSV) may T2DM by targeting Sirtuin 1 (SIRT1), indicating SIRT1 be target for prevention. In the present study, rat model was established administering high fat diet streptozotocin (STZ) injections. Measurements blood glucose insulin confirmed successful establishment model. RSV used rats with...
<h3>Importance</h3> Multiple states have laws requiring abortion facilities to meet ambulatory surgery center (ASC) standards. There is limited evidence regarding abortion-related morbidities and adverse events following abortions performed at ASCs vs office-based settings. <h3>Objective</h3> To compare <h3>Design, Setting, Participants</h3> Retrospective cohort study of women with US private health insurance who underwent induced in an ASC or setting (January 1, 2011-December 31, 2014)....
Abstract Background In recent years, there have been many studies on the relationship between DLGAP5 and different types of cancers, yet is no pan-cancer analysis DLGAP5. Therefore, this study aims to analyze roles in human tumors. Methods Firstly, we evaluated expression level 33 tumors throughout datasets TCGA (Cancer Genome Atlas) GEO (Gene Expression Synthesis). Secondly, used GEPIA2 Kaplan-Meier plotter conduct Survival prognosis analysis. Additionally, cBioPortal web was utilized...
Abstract RNF2 is a RING domain-containing E3 ubiquitin ligase that mediate histone H2A mono-ubiquitination to repress gene transcription, but its expression patterns and molecular function in hepatocellular carcinoma (HCC) remain unclear. Herein, we extracted data from TGCA database validated our own cohort, which revealed was highly expressed HCC associated with malignant characteristics poor prognosis of HCC. Moreover, demonstrated promote metastasis via enhancing epithelial-mesenchymal...
Importance Research has found associations of pregnancy-specific alcohol policies with increased low birth weight and preterm birth, but other infant outcomes are unknown. Objective To examine the morbidities maltreatment. Design, Setting, Participants This retrospective cohort study used outcome data from Merative MarketScan, a national database private insurance claims. The included individuals aged 25 to 50 years who gave singleton between 2006 2019 in US, had been enrolled 1 year before...
Pseudomyxoma peritonei (PMP) is a rare disease characterized by extensive peritoneal implantation and mass secretion of mucus after primary mucinous tumors the appendix or other organ ruptures. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) currently preferred treatment, excellent efficacy safety, associated breakthrough progress in long-term control prolonged survival. However, high recurrence rate PMP key challenge its which limits clinical...
The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial, and more high-level clinical evidence is needed. This study aimed to evaluate the outcome extended (EPD) with retroperitoneal nerve resection in cancer.This multicenter randomized trial was performed at 6 Chinese high-volume hospitals that enrolled patients between October 3, 2012, September 21, 2017. Four hundred stage I or II without specific treatments (preoperative chemotherapy chemoradiation) within...
The aim of the current study was to investigate expression proliferation antigen, Ki67, in triple-negative breast cancer (TNBC) and its correlation with clinicopathological factors. Ki67 other biological indicators 24 cases TNBC tissues 178 non-TNBC were detected using immunohistochemistry. Their factors also analyzed χ2 test. positive rate 83.3%, exhibiting a statistically significant difference when compared that (73.0%) (P<0.05). tissue significantly correlated tumor size lymph node...
Central nervous system (CNS) brain metastasis of advanced non-small cell lung cancer (NSCLC) patients confers a worse quality life and prognosis. The efficacy comparison two first-generation epidermal growth factor receptor (EGFR) inhibitors erlotinib or gefitinib as first-line treatment for CNS NSCLC with EGFR-sensitizing mutations is yet to be elucidated.A retrospective analysis was done on cerebral rate after mutations. Time neurological progression (nTTP) median progression-free survival...
Due to the abnormal vasculation and proliferation, tumor microenvironment is hypoxic, lacking nutrients, under high interstitial pressure. Compared oxygen effect of pressure on cancer biology remains poorly studied. Here we constructed αROR1-CAR T cells co-cultured with A549 without elevated We then measured apoptosis cell death by flow cytometry luciferase activity. also cytokine (IL-2, IFN-γ, TNF-α) release ELISA. The results show that pressure-preconditioned are much resistant...
The aim of this study was to determine the effects simvastatin and atorvastatin on markers oxidative stress in patients with type 2 diabetes mellitus (T2DM). population consisted 151 T2DM 147 control individuals. were treated 40 mg per day or 10 day. Waist circumference, body mass index, blood pressure, glucose insulin values obtained; fasting serum lipids, malondialdehyde, nitric oxide, glutathione peroxidase superoxide dismutase activity determined before after 12 weeks treatment. Statin...
Liver cancer is one of the most lethal malignant tumors in world. The high recurrence and mortality rate make it urgent for scientists clinicians to find new targets better treatment liver cancer. Here, we found that circ-PRKAR1B expression was increased paired intrahepatic metastasis sample through high-throughput sequencing. Further experiments also confirmed its both carcinoma when compared para-carcinoma carcinoma, respectively. Mechanism study showed could promote progression...