Human stem cells and progenitor can be used to treat cancer replace dysfunctional within a tissue or organ. The objective of this study was identify the appropriate type in regenerative medicine targeted therapy. As an alternative embryonic bone marrow cells, we examined human amniotic fluid (hAFSCs), one potential source multipotent isolated from both cell pellet (using single-stage method), supernatant fluid. Source isolation unique property emphasize that these are promising new tools...

Myocardial infarction is one of the most common life threatening diseases that may lead to renal disorders via oxidative stress and inflammation. Betaine a safe well-tolerated compound exhibiting beneficial antioxidant anti-inflammatory properties. Previous studies have demonstrated protective effects betaine against myocardial injury. This study aimed investigate effect on tissue structure function after isoprenaline-induced in rats.Fifty Wistar strain male albino rats, weighing 200 ± 10,...

A growing body of evidence indicated that Alantolactone (ALT) promotes Reactive Oxygen Species (ROS) generation exclusively in cancer cells. Therefore, the aim this study was to investigate effect ALT on molecular mechanism oxeiptosis, as a novel cell death pathway due high levels intracellular ROS ovarian cancer. MTT assay used evaluate SKOV3 viability. mRNA and protein expression Nrf2 (nuclear factor erythroid 2-related 2), KEAP1 (Kelch-like ECH-associated 1), PGAM5 (phosphoglycerate...

MicroRNAs (miRs) play a pivotal role in the pathogenesis of viral infections. It has been proven that Nrf2 (NFE2 like bZIP transcription factor 2) antioxidant signaling pathway is inhibited COVID-19 patients. Two microRNAs (MIR144 and MIR153-1) have identified as important regulators. The aim this study was to analyze MIR144 MIR153-1 expression patients investigate their association with pathway. had 82 participants both mild severe manifestations 25 healthy control group. Ficoll...

Abstract Purpose One of the most common malignancies peculiar to female health with few symptoms, low response therapy, difficult diagnosis, frequent relapse, and high mortality, is ovarian cancer. Thus, our experiment, using Human amniotic fluid mesenchymal stem cells (hAFMSCs) as a therapeutic tool, aims find an efficient treatment approach for patients suffering from SKOV3 Material & Methods In this study, we obtained 5 ml 16–20 week pregnant women who underwent amniocentesis routine...

Ovarian cancer is one of the leading causes mortality in women. Despite increase cases this cancer, current therapeutic strategy not effective. This study aimed to investigate effect cisplatin (Cis) with alantolactone (ALT) and ZnO nanoparticles (ZnONPs) inducing apoptosis SKOV3 ovarian cells line.To evaluate viability determine IC50 Cis, ALT, ZnONPs, MTT assay was used. Real-time PCR western blotting were used expression levels genes (XIAP, cyclin D1, Bcl-2, Bax, MDM2) proteins Bax),...

Cancer stem cells (CSCs), as the subpopulation of cancer cells, are associated with carcinogenesis, chemoresistance, and metastasis in malignancies. Also, CSCs considered major reason for treatment failure prostate (PCa). Alantolactone (ALT), exerts anticancer activity different types cancers. In present study, relationship between ALT PCa molecular mechanisms involved progression were investigated.In this to evaluate cell viability, MTT assay was performed. Then, PC3 treated nontoxic...

New Findings What is the central question of this study? Do changes in levels angiogenesis‐related mediators [vascular endothelial growth factor‐A (VEGF‐A), thrombospondin‐1 (TSP‐1) and nuclear factor‐κB (NF‐κB)] sciatic nerve mediate diabetic neuropathy streptozotocin‐induced type 1 male rat? Can exercise insulin‐like factor (IGF‐I) treatment improve diabetes‐related decrease angiogenesis these animals? main finding its importance? Levels VEGF‐A, TSP‐1 NF‐κB change rats might neuropathy....

This study aimed to evaluate the effect of tropisetron on liver injury induced by diabetes. Thirty-five male Wistar rats were assigned five groups (n = 7): control (C), (T), diabetic (D), + (D T) and glibenclamide G). Diabetic treated with (3 mg/kg body weight/day) or (1 mg/kg/day) for two weeks. Liver from exhibited a significant increase in alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP), cholesterol (Chol), triglycerides (TG), low-density lipoprotein (LDL),...

Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with renoprotective effects tropisetron in STZ-induced diabetic rats. Animals were subdivided into 5 equal groups; control, tropisetron, diabetes, + and glibenclamide diabetes (n = 7). For induction type 1 single injection STZ (55 mg/kg, i.p.) administered animals. Diabetic rats treated (3 mg/kg) (1 for 2 weeks. According...