A5041726596- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- melanin and skin pigmentation
- Adrenal Hormones and Disorders
- Multiple Sclerosis Research Studies
- Innovations in Medical Education
- Orthopedic Infections and Treatments
- Ocular Disorders and Treatments
- Fungal Infections and Studies
- Corneal surgery and disorders
- Stress Responses and Cortisol
- Healthcare Quality and Management
- Autoimmune Bullous Skin Diseases
- Drug-Induced Ocular Toxicity
- Cerebral Venous Sinus Thrombosis
- Traumatic Ocular and Foreign Body Injuries
- Vascular Malformations Diagnosis and Treatment
- Dental Education, Practice, Research
- Corneal Surgery and Treatments
- Cutaneous lymphoproliferative disorders research
Manchester Royal Eye Hospital
2017-2024
University of Manchester
2024
Manchester University NHS Foundation Trust
2020-2023
Bolton NHS Foundation Trust
2023
Royal Bolton Hospital
2023
University of Liverpool
2023
Health & Life (Taiwan)
2023
Oxford University Hospitals NHS Trust
2018-2020
John Radcliffe Hospital
2018-2020
University of Oxford
2018
Importance X-linked retinitis pigmentosa (XLRP) is a severe cause of early-onset RP in male individuals, characterized by degeneration photoreceptors, an extinguished electroretinogram, and vision loss. Objective To assess the duration improvements retinal sensitivity associated with single, subretinal injection cotoretigene toliparvovec (BIIB112/AAV8-RPGR) gene therapy after vitrectomy surgery dosed eye over 12 months part 1 Clinical Trial Retinal Gene Therapy for Retinitis Pigmentosa Using...
Fundus autofluorescence (AF) arises from lipofuscin, which is derived retinoid byproducts of the visual cycle and accumulates within retinal pigment epithelial cells. Alterations in AF pattern are seen a wide range degenerations. Choroideremia an X-linked dystrophy caused by loss-of-function mutations CHM gene, encoding Rab escort protein-1.1van den Hurk J.A. Schwartz M. van Bokhoven H. et al.Molecular basis choroideremia (CHM): involving protein-1 (REP-1) gene.Hum Mutat. 1997; 9:...
To evaluate a sequential approach of pneumatic displacement followed by vitrectomy (pars plana vitrectomy) in failed cases to deal with submacular hemorrhage (SMH) various etiologies.Retrospective, nonrandomized interventional case series consecutive patients SMH up 2 weeks' duration, who were treated stepwise approach. Step 1 involved intravitreal injection 0.3 mL 100% C3F8 and recombinant tissue plasminogen activator 50 μg/0.1 mL. If unsuccessful, prompt pars subretinal 20% SF6 gas...
The UK Government imposed a COVID19 lockdown (LD) restricting all but essential activities from 24th March 2020. Subsequently, there has been significant reduction in casualty attendances nationwide including for ophthalmic emergencies. We aim to study the presentation of rhegmatogenous retinal detachments (RRD) and vitreous haemorrhage caused by posterior detachment (PVD-VH) three tertiary centres covering most North West England 6 weeks before during lockdown.A retrospective multicenter...
To compare SF 6 relative with C 2 F in the anatomical and functional outcomes following pars plana vitrectomy for uncomplicated primary pseudophakic rhegmatogenous retinal detachment inferior causative breaks.
We investigate novel OCT parameters, based on the volumetric analysis of lamellar macular holes (LMHs), as prognostic indicators for visual outcomes after surgery.
Torpedo maculopathy is a rare congenital anomaly of the retinal pigment epithelium (RPE). Various imaging modalities have been used to assess cases torpedo maculopathy, including optical coherence tomography (OCT) and fundus autofluorescence (FAF). OCT angiography (OCTA) offers combined structural flow characteristics imaged lesions. The authors present OCTA findings in two maculopathy. Common features include loss RPE choriocapillaris allowing greater visualization larger vessels outer...
A 54-year-old female with history of relapsing remitting multiple sclerosis (MS) was switched from interferon beta-1A (Avonex, Biogen) to fingolimod (Gilenya, Novartis) therapy after having two clinical relapses within 2 years while on treatment. As part her treatment protocol, she referred the local ophthalmology unit for a baseline screen and periodic review thereafter. Three months into treatment, complained blurring vision in right eyeA visual acuity assessment showed reduction...
Background The retinol binding protein 4 (RBP4) is essential in delivering to the retinal pigment epithelium and normal functioning of visual cycle. Homozygous mutations RBP4 gene lead severe retinitis pigmentosa that phenotypically indistinguishable from caused by other recessive mutations.Methods Case Report.Purpose To report a novel homozygous c.67 C > T variant case associated with childhood acne vulgaris.Results A 49-year old Caucasian man family history pigmentosa, presented low vision...
To quantify the rate of idiopathic macular hole progression from presentation and identify factors that may influence stratification urgency for surgical listing based on initial optical coherence tomography scans.The minimal linear diameter (MLD), base (BD), height nasal temporal sides were measured spectral domain tomographies, just before surgery. Mean height, asymmetry (absolute difference between height), MLD/BD, MLD change per day (MLD/day) calculated each patient. Multivariable...
A man in his 50s underwent vitrectomy surgery for a macular off retinal detachment which was complicated by intraoperative hypotony and suprachoroidal haemorrhage, resulting the use of silicone oil tamponade. Postoperatively, several retained cysts fluid were seen underneath retina, one large close to macular. Imaging used determine that this likely oil. Given potential migration toxicity, decision made remove larger bubbles under retina. We explain how may have got retina unusual case, we...
We describe a novel technique that allows safe extraction of buried Kuntscher nail during total hip arthroplasty in patient with ipsilateral, symptomatic post-traumatic osteoarthritis the hip. This method surgeon to visualise antegrade entry point allowing device without compromising result arthroplasty.
To determine the prevalence of disposable tonometer versus non-disposable use in UK and to methods decontamination frequency replacement prisms.A total 137 ophthalmology departments were interviewed by telephone using a structured questionnaire. The main outcome measured were:types prisms used clinic (disposable, and/or other)average per sessionaverage lifespan prismsprism preference glaucoma other teams within department.A cost benefit analysis was then performed on data acquired.One...
Gyrate atrophy is a rare autosomal recessive disorder caused by mutation in the ornithine-δ-amino transferase gene. We present an interesting case of 33-year-old woman who presented with increasing myopia, nyctalopia and failing vision. Examination revealed posterior subscapsular cataracts, narrowed peripheral visual fields scalloped atrophic chorioretinal lesions. Blood investigations showed raised plasma ornithine level at 917 μmol/L (normal range: 32–88 μmol/L) confirming diagnosis gyrate...
Objective: Pachymetry plays a crucial role in the diagnosis and management of glaucoma corneal diseases. There have been several outbreaks epidemic ocular infections ophthalmology clinics worldwide with reports viral, parasitic, prion disease. Contact pachymetry is possible vehicle transmission due to its risk contamination. We aim identify types used methods employed for cleaning disinfection eye units throughout United Kingdom. Methods: A telephone survey was carried out, senior nurse or...
Suprachoroidal hemorrhage (SCH) is an uncommon sight-threatening pathology, most often encountered intraoperatively. However, spontaneous presentation of SCH even rarer. We report the case a 69-year-old diabetic patient with (SSCH) in her left eye masquerading as vitreous hemorrhage. She developed treatment-resistant secondary angle-closure glaucoma. was referred to vitreoretinal team for intraocular exploration identify source Pars plana vitrectomy identified extensive As far authors are...
Abstract Purpose: To assess the long-term visual recovery in uncomplicated macula-off pseudophakic rhegmatogenous retinal detachment (PRRD) treated with pars plana vitrectomy (PPV) and gas tamponade absence of other co-morbidities. Methods: Single-centre retrospective longitudinal study on eyes PRRD successfully PPV between 2011 2020 at least two follow-ups (FU), first gas-free FU (first-FU) a final FU, were included. Patients subsequent ocular surgery or comorbidities affecting BCVA...