A5059365545- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- RNA regulation and disease
- Neural Networks and Applications
- Memory and Neural Mechanisms
- Drug Transport and Resistance Mechanisms
Karolinska Institutet
2023-2024
University of Freiburg
2017-2020
Bernstein Center for Computational Neuroscience Freiburg
2018-2020
Mesial temporal lobe epilepsy (MTLE) is the most common form of focal, pharmacoresistant in adults and often associated with hippocampal sclerosis. Here, we established efficacy optogenetic electrical low-frequency stimulation (LFS) interfering seizure generation a mouse model MTLE. Specifically, applied LFS sclerotic hippocampus to study effects on spontaneous subclinical evoked generalized seizures. We found that at 1 Hz for hr resulted an almost complete suppression seizures both...
Mesial temporal lobe epilepsy (mTLE) is the most common focal in adults and often refractory to medication. So far, resection of epileptogenic focus represents only curative therapy. It unknown whether pathological processes preceding onset are indicators later disease severity. Using longitudinal multi-modal MRI, we monitored hippocampal injury tissue reorganization during epileptogenesis a mouse mTLE model. The prognostic value MRI biomarkers was assessed by retrospective correlations with...
Abstract Mesial temporal lobe epilepsy (MTLE), the most common form of focal in adults, is often refractory to medication and associated with hippocampal sclerosis. Deep brain stimulation represents an alternative treatment option for drug-resistant patients who are ineligible resective surgery. In clinical practice, closed-loop at high frequencies applied interrupt ongoing seizures, yet has (i) a incidence false detections; (ii) drawback delayed seizure-suppressive intervention; (iii)...
In mesial temporal lobe epilepsy (mTLE) an initial precipitating injury can trigger aberrant wiring of neuronal circuits causing seizure activity. While circuit reorganization is known to be largely activity-dependent, the interactions between activity and synaptic plasticity during development mTLE remain poorly understood. Therefore, present study aimed at delineating spatiotemporal relationship epileptic activity, activity-dependent gene expression kainic acid-induced epileptogenesis in...
Mesial temporal lobe epilepsy is characterized by focal, recurrent spontaneous seizures, sclerosis and granule cell dispersion (GCD) in the hippocampal formation. Changes theta rhythm properties have been correlated with severity of restructuring were suggested as a cause memory deficits accompanying epilepsy. For severe sclerosis, it has even questioned whether band oscillations persist. We asked how change graded along longitudinal axis these changes correlate overall recorded local field...
Hypersynchronous network activity is the defining hallmark of epilepsy and manifests in a wide spectrum phenomena, which electrographic during seizures only one extreme. The aim this study was to differentiate between different types epileptiform (EA) patterns investigate their temporal succession interactions. We analyzed local field potentials (LFPs) from freely behaving male mice that had received an intrahippocampal kainate injection model mesial lobe (MTLE). Epileptiform spikes occurred...
Abstract Epileptiform activity (EA) manifests in diverse patterns of hypersynchronous network activity. Fundamental research mostly addresses two extreme patterns, individual epileptiform spikes and seizures. We developed PEACOC to detect classify a wide range EA local field potentials. delimits as bursts spikes, classifies these according spike load. In from kainate-injected mice, burst displayed continuum loads. With PEACOC, we partitioned this into high, medium low High-load resembled...
Abstract Mesial temporal lobe epilepsy (MTLE), the most common form of focal in adults, is often refractory to medication and associated with hippocampal sclerosis. Deep brain stimulation represents an alternative treatment option for drug-resistant patients who are ineligible resective surgery. In clinical practice, closed-loop at high frequencies applied interrupt ongoing seizures, yet a incidence false detections, drawback delayed seizure-suppressive intervention limited success sclerotic...
Abstract The intrinsic organization underlying the central cognitive role of prefrontal cortex (PFC) is poorly understood. work to date has been dominated by cytoarchitecture as a canvas for studies on PFC, constraining concepts, analyses, results, and their interpretations pre-configured delimitations that might not be relevant function. We approached profiling activity spatial location >23,000 neurons recorded in awake mice. Regularly firing were over-represented most PFC subregions,...
Abstract Mesial temporal lobe epilepsy (MTLE) is the most common form of focal in adults and typically associated with hippocampal sclerosis drug-resistant seizures. As an alternative to curative surgery, brain stimulation evolves as a promising approach for seizure-interference. However, particularly MTLE severe sclerosis, current protocols are often not effective. Here, we show that optogenetic low-frequency (oLFS) entorhinal afferents exhibits unprecedented anti-ictogenic effects...