A5075727557- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Atrial Fibrillation Management and Outcomes
- Data Mining Algorithms and Applications
- Corporate Law and Human Rights
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Immunotherapy and Immune Responses
- Cardiovascular Issues in Pregnancy
- Advanced MRI Techniques and Applications
- Text Readability and Simplification
- Simulation Techniques and Applications
- International Law and Human Rights
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- International Law and Aviation
- Health Systems, Economic Evaluations, Quality of Life
- Congenital Heart Disease Studies
- Advanced Neuroimaging Techniques and Applications
University of Pennsylvania
2023-2025
Stanford University
2024-2025
Menlo School
2024
University of Colorado Denver
2020-2024
Children's Hospital of Philadelphia
2022-2023
Division of Undergraduate Education
1999
Background Rates of oral anticoagulation (OAC) nonprescription in atrial fibrillation approach 50%. Understanding reasons for OAC may reduce gaps guideline‐recommended care. We aimed to identify from clinical notes using large language models. Methods identified all patients and associated our health care system with a clinician‐billed visit without another indication stratified them on the basis active prescriptions. Three annotators labeled 10% (“annotation set”). engineered prompts...
Abstract Aims Right ventricular (RV) failure (RVF) after left assist device (LVAD) implant is an important cause of morbidity and mortality. Modern, data‐driven approaches for defining predicting RVF have been under‐utilized. Methods Two hundred thirty‐two patients were identified with a mean age 55 years; 40 (17%) women, 132 (59%) Caucasian 74 (32%) Black. Patients split between Interagency Registry Mechanically Assisted Circulatory Support (INTERMACS) Classes 1, 2 3 (25%, 38% 34%,...
Antigen encounter directs CD4+ T cells to differentiate into helper or regulatory cells. This process focuses the immune response on invading pathogen and limits tissue damage. Mechanisms that govern cell versus fate remain poorly understood. Here, we show E3 ubiquitin ligase Cul5 determines selection in by regulating IL-4 receptor signaling. Mice lacking develop Th2 Th9 inflammation pathophysiological features of atopic asthma. Following activation, forms a complex with CIS pJak1. deletion...
Abstract During infection, virus-specific CD8 + T cells undergo rapid bursts of proliferation and differentiate into effector that kill virus-infected reduce viral load. This clonal expansion can put at significant risk for replication-induced DNA damage. Here, we find c-Myc links cell to damage response pathways though the E3 ubiquitin ligase, Cullin 4b (Cul4b). Following activation, increases levels Cul4b other members RING Ligase 4 (CRL4) complex. Despite expressing high levels,...
Abstract Granzymes are a family of proteases used by CD8 T cells to mediate cytotoxicity and other less-defined activities. The substrate mechanism action many granzymes unknown, although they diverge among the members. In this study, we show that mouse CD8+ tumor-infiltrating lymphocytes (TILs) express unique array relative outside tumor microenvironment in multiple models. Granzyme F was one most highly upregulated genes TILs exclusively detected PD1/TIM3 double-positive TILs. To determine...
Introduction/Aims: Anticoagulation (AC) reduces the risk of stroke in atrial fibrillation (AF), yet nonprescription rates near 50%. Reasons for this care gap are not well understood. Large language models (LLMs) may be able to extract documented reasons AC from unstructured text clinical notes. Methods: We created a cohort all index patient encounters with clinician-billed ICD10 diagnosis code AF at Stanford Health Care January 1, 2015 through December 31, 2023. Three trained reviewers...
Abstract Granzymes are a class of proteases produced by CD8 T cells to mediate their cytotoxic activity against target cells. The objective this project is determine the mechanism through which executing granzyme-mediated function and how tumor microenvironment (TME) impacts specific granzymes produced. By micro-array qPCR we determined that in TME have altered expression granzymes. Granzyme F had one most expressions all genes examined antigen-specific taken from spleen relative those...