A5078917700- Photochromic and Fluorescence Chemistry
- Luminescence and Fluorescent Materials
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Properties of Aromatic Compounds
- Synthesis and characterization of novel inorganic/organometallic compounds
- Coordination Chemistry and Organometallics
- Molecular Sensors and Ion Detection
- Photochemistry and Electron Transfer Studies
- Organoboron and organosilicon chemistry
- Organic Electronics and Photovoltaics
- Organometallic Complex Synthesis and Catalysis
- Crystallography and molecular interactions
- Click Chemistry and Applications
- Lipid Membrane Structure and Behavior
- Synthesis of Indole Derivatives
Uppsala University
2021-2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2022
Abstract This minireview describes the syntheses, structure‐photophysical properties relationship, and bioimaging applications of fluorescent coumarins, xanthenes, BODIPYs, cyanines. Advantages disadvantages emissive units are also discussed, as general practical issues that need to be considered when using fluorophores in a biological setting.
The chemical reduction of a π-expanded polycyclic framework comprising cyclooctatetraene moiety, octaphenyltetrabenzocyclooctatetraene, with lithium metal readily affords the corresponding tetra-anion instead expected aromatic dianion. As revealed by X-ray crystallography, highly contorted is stabilized coordination two internally bound Li+ , while external cations remain solvent separated. variable-temperature 7 Li NMR spectra in THF confirm presence three types ions and clearly...
Abstract In this study, we present a series of solvatochromic phenylbenzothiadiazoles that display dual emission from the locally excited (LE) and intramolecular charge transfer (ICT) states. The donor‐acceptor derivatives are highly sensitive to polarity changes, which can be monitored by differences in efficiency, spectroscopic shifts variations LE/ICT ratio. One compounds series, containing thiomethyl substituent, emerged as an excellent blue emitting stain for intracellular lipid...
The chemical reduction of a π-expanded COT derivative, octaphenyltetrabenzocyclooctatetraene (1), with lithium or sodium metals in the presence secondary ligands affords new doubly-reduced product (1TR2-). X-ray diffraction study revealed reductive core rearrangement accompanied by formation single C-C bond and severe twist central tetraphenylene core. reversibility two-electron transformation is further confirmed NMR spectroscopy DFT calculations.
In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various N-substituents in the 4-position was synthesized and photophysically characterized solvents. Three compounds emerged as excellent probes for imaging lipid droplets cancer cells. A correlation between their high lipophilicity droplet specificity could be found, log P ≥ 4 being characteristic accumulation.
Abstract The chemical reduction of a π‐expanded polycyclic framework comprising cyclooctatetraene moiety, octaphenyltetrabenzocyclooctatetraene, with lithium metal readily affords the corresponding tetra‐anion instead expected aromatic dianion. As revealed by X‐ray crystallography, highly contorted is stabilized coordination two internally bound Li + , while external cations remain solvent separated. variable‐temperature 7 NMR spectra in THF confirm presence three types ions and clearly...
We present an extensive photophysical study of a series fluorescent indolylbenzothiadiazole derivatives and their ability to specifically image lipid droplets in astrocytes glioblastoma cells. All compounds the displayed positive solvatochromism together with large Stokes shifts, π-extended exhibited elevated brightness. It was shown that fluorescence properties were highly tunable by varying electronic character or size N-substituent on indole motif. Three proved capable as probes for...
The study of a fluorescent indolin-3-one derivative is reported that, as opposed to its previously described congeners, selectively undergoes photoactivated ring-opening in apolar solvents. excited state involved this photoisomerization was partially deactivated by the formation singlet oxygen. Cell studies revealed lipid droplet accumulation and efficient light-induced cytotoxicity.
Abstract This work presents the pH sensing ability of a fluorescent indolin‐3‐imine derivative. Protonation weakly basic imine (p K =8.3 its conjugate acid) results in significant red‐shift absorption band. The fluorophore acts as photobase, with basicity increase approximately 6 units upon photoexcitation. behavior promotes excited state proton transfer from weak acids such protic solvents. characteristics enable water fractions organic solvents and differentiation between methanol,...