A5043039866- Microbial Metabolic Engineering and Bioproduction
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Enzyme Production and Characterization
- Coenzyme Q10 studies and effects
- Metabolism, Diabetes, and Cancer
- Protein Hydrolysis and Bioactive Peptides
- Antibiotic Resistance in Bacteria
- vaccines and immunoinformatics approaches
- Bioinformatics and Genomic Networks
- Hepatitis B Virus Studies
- Toxoplasma gondii Research Studies
- Fungal and yeast genetics research
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Photosynthetic Processes and Mechanisms
- Enzyme Catalysis and Immobilization
Queen's University Belfast
2017-2020
Universidade Estadual Paulista (Unesp)
2010
Klebsiella pneumoniae is a significant cause of nosocomial pneumonia and an alarming pathogen owing to the recent isolation multidrug resistant strains. Understanding immune responses orchestrating K. clearance by host utmost importance. Here we show that type I interferon (IFN) signaling protects against lung infection with launching bacterial growth-controlling interactions between alveolar macrophages natural killer (NK) cells. Type IFNs are important but disparate incompletely understood...
Klebsiella pneumoniae has been singled out as an urgent threat to human health due the increasing isolation of strains resistant “last-line” antimicrobials, narrowing treatment options against infections. Unfortunately, at present, we cannot identify candidate compounds in late-stage development for multidrug-resistant infections; this pathogen is exemplary mismatch between unmet medical needs and current antimicrobial research pipeline. Furthermore, there still limited evidence on K....
Mammalian electron transfer flavoproteins comprise a mitochondrial matrix heterodimer, and an flavoprotein dehydrogenase localized in the inner membrane. Electrons from primary acyl-CoA dehydrogenases, of metabolism fatty acids amino acids, are transferred to matricial heterodimer and, subsequently, dehydrogenase, which transfers electrons ubiquinone transport chain. Several evidences suggest that these proteins may convey directly molecular oxygen, yielding reactive oxygen species. In this...
ABSTRACT Klebsiella pneumoniae is an important cause of multidrug resistant infections worldwide. Understanding the virulence mechanisms K. a priority and timely to design new therapeutics. Here we demonstrate that limits SUMOylation host proteins in epithelial cells macrophages (mouse human) subvert cell innate immunity. Mechanistically, lung increases levels deSUMOylase SENP2 cytosol by affecting its K48-ubiquitylation subsequent degradation ubiquitin proteasome. This dependent on...