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Thomas M. Rust

ORCID: 0000-0003-2000-8141
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About
Contact & Profiles
A5027251858
Research Areas
  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • CRISPR and Genetic Engineering
  • Tryptophan and brain disorders
  • Cancer-related molecular mechanisms research
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

University Medical Center Groningen
 2024

University of Groningen
 2024

 Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease
OPENALEX - Publications 
Neta Rosenzweig Kilian Kleemann Thomas M. Rust Madison Carpenter Madeline Grucci and 21 more Michael Aronchik Nieske Brouwer Isabel M. E. Valenbreder Joya Cooper-Hohn Malvika Iyer Rajesh K. Krishnan Kisha N. Sivanathan Wesley Nogueira Brandão Taha Yahya Ana Durao Zhuoran Yin Jean Paul Chadarevian Michael J Properzi Roni Nowarski Hayk Davtyan Howard L. Weiner Mathew Blurton‐Jones Hyun‐Sik Yang Bart J. L. Eggen Reisa A. Sperling Oleg Butovsky

10.1038/s41591-024-03122-3 article EN Nature Medicine 2024-07-03
 Single-cell X-chromosome inactivation analysis links biased chimerism to differential gene expression and epigenetic erosion
OPENALEX - Publications 
Robert H. Henning Thomas M. Rust Kasper Dijksterhuis Bart J. L. Eggen Victor Guryev

Abstract Female cells randomly inactivate one X-chromosome, resulting in cellular mosaicism. Determining the bias X-chromosomal inactivation (XCI) at single cell level may be relevant for understanding diseases prevalent females. Here, we introduce a computational method that determines XCI profiles single-cell using solely sc/snRNA-Seq data. analysis of skin from hybrid mice validates our approach and reveals biased X-chromosomes among types. In human lung brain cells, status can determined...

10.1101/2024.08.29.610317 preprint EN cc-by-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-08-30
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