A5037637875- Nanoplatforms for cancer theranostics
- Chromosomal and Genetic Variations
- Anesthesia and Neurotoxicity Research
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Nanoparticles: synthesis and applications
- Mitochondrial Function and Pathology
- Fungal and yeast genetics research
- ATP Synthase and ATPases Research
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
Wake Forest University
2016-2018
University of North Carolina at Chapel Hill
2016
Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor with a 5 year overall survival rate of approximately 5%. Currently, no therapy curative all have significant side effects. Focal thermal ablative therapies are being investigated as new therapeutic approach. Such can be enhanced using nanotechnology. Carbon nanotube mediated (CNMTT) uses lasers that emit near-infrared radiation to excite carbon nanotubes (CNTs) localized generate heat needed for ablation....
P-Glycoprotein (Pgp)-medicated multidrug resistance (MDR) remains a formidable challenge to cancer therapy. As conventional approaches using small-molecule inhibitors failed in clinical development because of the lack specificity, we develop Pgp-targeted carbon nanotubes achieve highly cancer-specific therapy through combining antibody-based targeting and locoregional tumor ablation with photothermal Through dense coating phospholipid-poly(ethylene glycol), have engineered multiwalled...
Transcriptional inactivation of the budding yeast centromere has been a widely used tool in studies chromosome segregation and aneuploidy. In haploid cells when an essential contains single conditionally inactivated (GAL-CEN), cell growth rate is slowed fidelity reduced; but colony formation nearly 100%. Pedigree analysis revealed that only 30% time both mother daughter inherit GAL-CEN chromosome. The reduced capacity further compromised upon reduction pericentric cohesin (mcm21∆), as...
Abstract Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor with a 5 year overall survival rate of approximately 5%. Currently, no therapy curative all have significant side effects. Focal thermal ablative therapies that heat malignant tissue to temperatures (>55°C) induce cell death are being investigated as novel treatment modality. Such can be enhanced by using nanotechnology, addition nanoparticles. Carbon nanotube mediated (CNMTT) uses lasers emit...