A5031331052- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Alcoholism and Thiamine Deficiency
- Nanoparticle-Based Drug Delivery
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Biochemical Acid Research Studies
- Protein purification and stability
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Metabolism and Genetic Disorders
- Advanced biosensing and bioanalysis techniques
- Quinazolinone synthesis and applications
- Analytical Chemistry and Sensors
- Hemoglobinopathies and Related Disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and Reactions of Organic Compounds
- Proteins in Food Systems
- Enzyme Catalysis and Immobilization
- Synthesis and biological activity
- Analytical Chemistry and Chromatography
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
University of Tehran
1981-2024
Aerospace Research Institute
2013
657 Oslo
2011
Apotex (Canada)
2003-2005
University of Toronto
1985-1989
Louisiana State University
1975-1978
Louisiana State University Agricultural Center
1976
A self-nanoemulsifying drug delivery system (SNEDDS) was developed as a novel route to enhance the efficacy of docetaxel lipophilic drug. SNEDDS comprised ethyl oleate, Tween 80 and poly(ethylene glycol) 600, oil, surfactant co-surfactant, formed stabilized monodispersed oil nanodroplets upon dilution in water. represented encapsulation efficiency loading capacity 21.4 52.7%, respectively. The release profile from drug-loaded recorded, its effectiveness against MCF-7 cell line investigated,...
Capecitabine (CAP) is an FDA-approved and frequently used chemotherapeutic agent for the treatment of various cancers. However, there are some side effects chemoresistance limiting its use. Nanotechnological approaches can enhance efficacy anticancer drugs. In this study, CAP-loaded nanoniosomes were prepared. Nanoniosomes prepared by method thin film hydration wherein CAP was loaded into nanoniosomes. then characterized field emission scanning electron microscopy (particle) vesicle size...
Docetaxel (DXL) is an antineoplastic agent for cancer treatment, the therapeutic efficiency of which limited due to low solubility, hydrophobicity, and tissue specificity.
A new self-nanoemulsifying drug delivery system (SNEDDS) was developed for erlotinib (Ert) oral delivery. pseudo-ternary phase diagram olive oil, Tween 80 and polyethylene glycol (PEG) 600 mixtures, firstly constructed. Based on the data about Ert solubility cytotoxicity of these components, a SNEDDS composed 10% 20% 70% (V/V) selected loading (Ert-SNEDDS). formed 31.2-nm droplets upon dilution in water, led to increment oil 83.9 ± 0.6 nm. Ert-SNEDDS represented capacity an entrapment...
A versatile synthetic route to potentially useful fused-ring [1,2,4]thiadiazole scaffolds (e.g., 7a and 10b) via exchange reactions of the precursor [1,2,4]thiadiazol-3-(2H)one derivatives 6 9) with appropriately substituted nitriles cyanogen bromide or p-toluenesulfonyl cyanide) under mild conditions is described. For example, tricyclic 3-bromo [1,2,4]THD derivative (7a) underwent S(N)Ar substitution a variety nucleophiles, which included amines, malonate esters alcohols. Likewise, bicyclic...
1. Palmityl-substituted Sepharose 4B prepared by the glycidyl ether method of S. Hjertén et al. [J. Chromatogr. (1974) 101, 281-288] has been used as a non-ionic matrix for protein adsorption. A number proteins, some which are catalytically active, may be immobilized on this adsorbent in form suspension or column. 2. Of proteins examined, bovine serum albumin, hemoglobin, myoglobin, lysozyme, glutamate dehydrogenase, and beta-galactosidase were irrespective NaCl concentration. Trypsin,...
Abstract Transfusional iron overload is a major cause of morbidity and mortality in thalassemia, sickle-cell disease other chronic anemias. To overcome these problems, orally bioavailable chelators, deferiprone deferasirox, were used for the treatment patients suffering from thalassemia. The interactions between deferasirox with carrier protein, β-thalassemia hemoglobin (Hb), investigated using fluorescence, circular dichroism (CD) UV-visible measurements at physiological condition. Strong...
A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy imatinib. The drug-loaded SNEDDS formed nanodroplets oleate stabilized by with diameter 81.0±9.5 nm. nanoemulsion-based stable for at least two months, entrapment efficiency loading capacity 16.4±0.1 48.3±0.2%, respectively. Imatinib-loaded evaluated release profiles, its effectiveness against MCF-7 cell line investigated....
A new class of selective FXIIIa inhibitors with a bicyclic [1,2,4]-thiadiazole pharmacophore is described. At 160 μM, compound 8 caused 50% reduction in fibrin γ-chain cross-linking and suppressed the polymerization α chains platelet-depleted human plasma clots. Fibrinolysis rates response to tissue plasminogen activator were directly proportional concentration at time clotting.
The synthesis of nanoflakes cobalt oxide via electrodeposition onto platinum electrode surface was reported. morphology the electrodeposited thin film studied by means scanning electron microscopy and atomic force techniques electrochemical characteristics were investigated using cyclic voltammetry. applicability synthesised to electrocatalytic oxidation two orally administered iron chelating drugs (deferasirox, ICL670 deferiprone, CP20) evaluated in an alkaline solution. results indicate...