A5010777233- Circular RNAs in diseases
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- RNA modifications and cancer
- Inflammatory Bowel Disease
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Analysis
- Dialysis and Renal Disease Management
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Natural Compounds in Disease Treatment
- Viral Infections and Immunology Research
- Renal Diseases and Glomerulopathies
- Metabolomics and Mass Spectrometry Studies
- Animal Disease Management and Epidemiology
- Autoimmune and Inflammatory Disorders
- HIV Research and Treatment
- Nephrotoxicity and Medicinal Plants
- BRCA gene mutations in cancer
- Berberine and alkaloids research
- Microscopic Colitis
- Chronic Kidney Disease and Diabetes
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
Zhongda Hospital Southeast University
2016-2024
Ministry of Education of the People's Republic of China
2023
Northwest University
2023
Inner Mongolia People's Hospital
2021
Lanzhou Veterinary Research Institute
2020
Chinese Academy of Agricultural Sciences
2020
Nanjing Medical University
2008-2018
Huaian First People’s Hospital
2018
Southeast University
2017
Jiangsu Province Hospital
2008-2016
Dysregulation of microRNAs (miRNAs) is associated with a variety diseases, including Crohn's disease (CD), but the essential biological functions and crucial targets miRNAs remain largely unknown. The present study investigated aberrant colonic mucosal in active CD patients. miRNA levels were assayed inflamed colon patients by quantitative real-time polymerase chain reaction. influence differential expressed miR-124 on its putative target, aryl hydrocarbon receptor (AHR), was patients,...
AIM:To investigate the biological role of miR-1290 in esophageal squamous cell carcinoma (ESCC) progression and invasion underlying mechanism. METHODS:Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to evaluate expression ESCC tissue samples.The roles proliferation, migration were identified using mimic-transfected cells.In addition, regulatory effect on suppressor cancer (SCAI) evaluated qRT-PCR, Western blot analysis a dual luciferase reporter assay.RESULTS:...
Background and objectives Impaired renal function in atherosclerotic renovascular disease (ARD) may be the result of crosstalk between stenosis amplified oxidative stress, inflammation fibrosis. Berberine (BBR) regulates cholesterol metabolism exerts antioxidant effects. Accordingly, we hypothesized that BBR treatment ameliorate ARD-induced kidney injury through its cholesterol-lowering effect also suppression pathways involved NFκB activation. Methods Male rats were subjected to unilateral...
Colorectal cancer (CRC) is one of the most frequent malignant tumors worldwide. The connection between lncRNAs expression and CRC development has not been well identified in recent literature. This study focuses on role lncRNA-SNHG1 progression development. quantitative Real-time PCR (qRT-PCR) assay was conducted to identify level small nucleolar RNA host gene 1 (SNHG1).Cell proliferation viability were examined by 3-(4,5)-dimethylthiazol(-z-y1)-3,5-diphenyl tetrazoliumbromide (MTT assay)...
Aims Atherosclerosis is a public health concern affecting many worldwide, but its pathogenesis remains unclear. In this study we investigated the role of IKKε during formation atherosclerosis and molecular mechanism in mouse aortic vessel wall. Methods Results C57BL/6 wild-type or knockout mice bred into ApoE genetic background were divided 4 groups: (1) (WT), (2) (AK), (3) (IK), (4) both (DK). Each group fed with high fat diet (HFD) for 12 weeks from 8 age. Immunohistochemistry Western...
Human immunodeficiency virus type 1 (HIV-1) Vif is required for productive infection of T lymphocytes and macrophages. Virions produced in the absence have abnormal core morphology those primary cells carry immature proteins low levels mature capsid (M. Simm, M. Shahabuddin, W. Chao, J. S. Allan, D. Volsky, Virol. 69:4582-4586, 1995). To investigate whether influences activity HIV-1 protease (PR), viral enzyme which responsible processing Gag Gag-Pol precursor polyproteins into virion...
Aims . To retrospectively analyze the clinical outcomes for a large number of endoscopic submucosal dissections (ESDs) in early esophageal squamous cell neoplasms (ESCNs) at First Affiliated Hospital Nanjing Medical University. Patients and Methods From January 2010 to February 2014, 296 patients (mean age 61.4 years, range 31–85 years; 202 men) with 307 ESCNs (79 intramucosal invasive carcinomas (ESCCs) 228 high-grade intraepithelial neoplasia (HGIN) cases) were included from total 519...
Background: The clinical significance of insulin-like growth factor-II mRNA-binding protein-3 (IGF2BP3) in esophageal high-grade intraepithelial neoplasia (HGIN) is not clear. This study was designed to characterize the expression IGF2BP3 HGIN. Patients and methods: evaluated by Western blot analyses 12 cases immunohistochemistry (IHC) 112 cases. associations between HGIN clinicopathological parameters were examined. Results: Moderate strong present samples. Using IHC, it found that positive...
Aims . This study was to compare the degradation, complications, and tissue reactions of two segmented biodegradable esophageal stents in a porcine model. Methods Uncovered fully covered (FCBDS) were transplanted into esophagus lumen. Data on biodegradation, collected compared. Results All animals kept good general conditions. No severe complications migration occurred. Stents degradation commenced at week 3. Compared with uncovered stents, structure breakage complete absorption FCBDS...
The high performance of chemiluminescence immunoassays (CLIAs) in diagnosis has been gradually recognized recent years, but their application the classical swine fever (CSF) not reported. Here, a recombinant E2 (rE2) protein and peroxidase-conjugated monoclonal antibody (MAb G5) were used to develop competition-based immunoassay (cCLIA) for rapid accurate detection E2-specific antibodies pig serum. To evaluate feasibility cCLIA CSF, we developed enzyme-linked immunosorbent assay (cELISA) as...
Abstract Background Chronic kidney disease (CKD) is associated with Immune deficiency. T lymphocytes are significant components of the adaptive immune system. Previous studies have found dysfunction in patients CKD,but changing trend absolute number and relationship infection has been still unclear CKD. Methods We collected 447 CKD, tested counts lymphocyte subsets, explored between count renal function, these impacts on infection. Results gradually decrease as CKD progresses. The...