A5090528258- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- RNA Research and Splicing
- Cerebrospinal fluid and hydrocephalus
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
Royal Netherlands Academy of Arts and Sciences
2009-2020
Netherlands Institute for Neuroscience
2009-2020
Royal Academy of Art
2009
Summary A main neurogenic niche in the adult human brain is subventricular zone (SVZ). Recent data suggest that progenitors are born SVZ migrate via rostral migratory stream (RMS) towards olfactory bulb (OB), similar to what has been observed other mammals. subpopulation of astrocytes specifically expresses an assembly‐compromised isoform intermediate filament protein glial fibrillary acidic (GFAP‐δ). To further define phenotype these GFAP‐δ expressing cells and determine whether present...
There are many indications that neurogenesis is impaired in Parkinson's disease, which might be due to a lack of dopamine the subventricular zone. An impairment may have negative consequences for development new therapeutic approaches as neural stem cells potential source endogenous repair. In this study, we examined zone 10 patients with disease and age- sex-matched controls proliferation cell numbers. We also included five cases incidental Lewy body showed pathology but no clinical...
Abstract In mice and in young adult humans, the subventricular zone (SVZ) contains multipotent, dividing astrocytes, some of which, when cultured, produce neurospheres that differentiate into neurons glia. It is unknown whether SVZ very old humans has this capacity. Here, we report neural stem/progenitor cells can also be cultured from rapid autopsy samples elderly human subjects, including patients with age‐related neurologic disorders. Histological sections these cases showed a glial...
The human GFAP splice variants GFAPΔ164 and GFAPΔexon6 both result in a protein isoform with unique out-of-frame carboxy-terminus that can be detected by the GFAP+1 antibody. We previously reported was expressed astrocytes degenerating neurons Alzheimer's disease brains. In this study we aimed at further investigating neuronal expression started affinity purifying purified antibody resulted loss of signal, although other antibodies directed against amino- GFAPα still revealed...
Dementia is a common feature in Parkinson's disease (PD) and considered to be the result of limbic cortical Lewy bodies and/or Alzheimer changes. Astrogliosis may also affect development dementia, since it correlates well with declining cognition patients. Thus, we determined whether astrogliosis occurs PD, related this reflected by presence glial fibrillary acidic protein (GFAP) vimentin cerebrospinal fluid (CSF). We have examined these proteins immunohistochemistry frontal cortex Western...
Abstract Neurogenesis continues throughout adulthood in specialized regions of the brain. One these is subventricular zone. During brain development, neurogenesis regulated by a complex interplay intrinsic and extrinsic cues that control stem-cell survival, renewal cell lineage specification. Cerebrospinal fluid (CSF) an integral part neurogenic niche development as it direct contact with radial glial cells, important regulating proliferation migration. Yet, effect CSF on neural stem cells...
Abstract In mice and in young adult humans, the subventricular zone (SVZ) contains multipotent, dividing astrocytes, some of which, when cultured, produce neurospheres that differentiate into neurons glia. It is unknown whether SVZ very old humans has this capacity. Here, we report neural stem/progenitor cells can also be cultured from rapid autopsy samples elderly human subjects, including patients with age‐related neurologic disorders. Histological sections these cases showed a glial...
ARTICLE Sir, We would like to thank Hoglinger and colleagues for their interest in our recent publication Brain (van den Berge et al ., 2011). In this study, we showed that the number of adult neural stem cells precursors main neurogenic niche human brain, subventricular zone, is not significantly diminished patients with Parkinson’s disease compared age- sex-matched controls. addition, provided evidence two different cell lines did respond an increase proliferation following exposure...
Abstract In mice and in young adult humans, the subventricular zone (SVZ) contains multipotent, dividing astrocytes, some of which, when cultured, produce neurospheres that differentiate into neurons glia. It is unknown whether SVZ very old humans has this capacity. Here, we report neural stem/progenitor cells can also be cultured from rapid autopsy samples elderly human subjects, including patients with age‐related neurologic disorders. Histological sections these cases showed a glial...