A5102717597- Radiomics and Machine Learning in Medical Imaging
- Autopsy Techniques and Outcomes
- Biochemical and Molecular Research
- AI in cancer detection
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Adenosine and Purinergic Signaling
- Immune Cell Function and Interaction
- Hematological disorders and diagnostics
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Acute Myeloid Leukemia Research
- Medical Imaging and Analysis
- Immune Response and Inflammation
- Gout, Hyperuricemia, Uric Acid
- Lung Cancer Treatments and Mutations
- Bone and Joint Diseases
- Telomeres, Telomerase, and Senescence
- Occupational and environmental lung diseases
- Cardiac Imaging and Diagnostics
- Acute Lymphoblastic Leukemia research
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- Neutropenia and Cancer Infections
- Forensic Entomology and Diptera Studies
University of Fukui
2014-2024
Kyushu University
2021
Institut national de recherche en informatique et en automatique
2021
East Asia School of Theology
2021
National Hospital Organization
2011-2015
Hiroshima University Hospital
2006
Segeberger Kliniken
2006
UNC Lineberger Comprehensive Cancer Center
2006
Hiroshima University
1989-2005
Journal Article Telomerase Activity in Small-Cell and Non–Small-Cell Lung Cancers Get access Keiko Hiyama, Hiyama Department of Cell Biology Neuroscience. The University Texas Southwestern Medical Center at Dallas Second Internal Medicine, Hiroshima School MedicineJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Eiso Neuroscience, Dallas, General Medicine Shinichi Ishioka, Ishioka Michio Yamakido, Yamakido Kouki Inai, Inai Pathology, Adi F. Gazdar, Gazdar...
Despite 75 to 90 % physician accuracy in determining the underlying cause of death, precision determination immediate death is approximately 40 %. In contrast, two thirds causes hospitalized patients are correctly diagnosed by postmortem computed tomography (CT). Postmortem CT might provide an alternative approach verifying death. To evaluate effectiveness as method determine patients, autopsy-based prospective study was performed. Of 563 deaths from September 2011 August 2013, 50...
To investigate the importance of gene amplification and EGFR (epidermal growth factor receptor) HER2 protein expression during progression adenocarcinoma lung.EGFR was examined in atypical adenomatous hyperplasia (AAH), bronchioloalveolar carcinoma (BAC), with mixed subtypes (MX) by chromogenic situ hybridisation (CISH), immunohistochemistry using paraffin wax embedded tissues.EGFR found four two 86 cases, respectively, detected only invasive components MX. seen 24 18 respectively. proteins...
AbstractAbstractMacrolide antibiotics are known to have a variety of immunomodulatory effects in addition antimicrobial activity, but the mechanisms immunomodulation still unclear. We investigated vitro effect azithromycin on tumor necrosis factor alpha (TNF-α) production lipopolysaccharide (LPS)-stimulated THP-1 cells, human monocytic cell line, and compared results with those for other macrolides, minocycline ofloxacin. In presence LPS, treatment (AZM) resulted significant decrease...
The excessive release of inflammatory cytokines occasionally induces life-threatening hemophagocytosis referred to as hemophagocytic syndrome (HPS). A similar condition, histiocytic hyperplasia with (HHH), is often seen in bone marrow collected during autopsy. Unlike HPS, the pathogenesis HHH remains unclear. Therefore, we performed a clinicopathological analysis from 70 autopsy cases at University Fukui Hospital. was detected 29 autopsies (41.4 %) and significantly complicated hematological...
Although organ weight gives pathologists information about the pathogenesis of diseases at autopsy, knowledge is rarely helpful in postmortem virtual autopsy by computed tomography ( CT ). To investigate feasibility liver estimation based on volume estimated from three‐dimensional images and specific gravity liver, thirty cadavers who died U niversity F ukui H ospital whose family members agreed to were prospectively enrolled. Mean was 1.054 ± 0.009 g/mL (95% confidence interval:...
Abstract Recently, we have found dramatic overexpression of ecto-5′-nucleotidase (or CD73), a glycosylphosphatidylinositol-anchored component lipid rafts, in estrogen receptor–negative [ER(−)] breast cancer cell lines and clinical samples. To find out whether there is more general shift expression profile membrane proteins, undertook an investigation on the selected cytoskeletal proteins aggressive metastatic cells. Our analysis revealed remarkably uniform broad range membrane, cytoskeletal,...
Thymic epithelial cells can produce many kinds of cytokines, and interleukin (IL)-6-producing thymic carcinoma cases have been reported. However, a cytokine-producing human tumor cell line has not previously established. In this paper, we report novel, multiple inflammatory cytokine-productive that was established from patient with carcinoma. This line, designated ThyL-6, positively expressed membrane antigen, cytokeratins, vimentin intermediate filament CD5, although hematological markers...
Monosodium urate (MSU) crystals have been reported to evoke specific cell immunity and work as an adjuvant in a mouse model. The also another unique characteristic bind with positively charged proteins, which could help deliver some antigens into human dendritic cells (DC). We focused on the application of MSU not only but carrier antigenic protein induce cytotoxic T (CTL) efficiently vitro . selected leukocyte antigen (HLA)‐A2 expressing multiple myeloma IM‐9 line its product idiotype (Id)...
Postmortem imaging (PMI) refers to the of cadavers by computed tomography (CT) and/or magnetic resonance (MRI). Three cases cerebral infarctions that were not found during life but newly recognized on PMI and associated with severe systemic infections are presented. An 81-year-old woman a pacemaker slightly impaired liver function presented fever. Imaging suggested interstitial pneumonia an iliopsoas abscess, blood tests showed dysfunction disseminated intravascular coagulation (DIC)....
Abstract Background Postmortem magnetic resonance imaging (MRI) has been used to investigate the cause of death, but due time constraints, it is not widely applied heart. Therefore, MRI analysis heart after formalin fixation was previously performed. However, changes in signal values based on were investigated. The objective over T1- and T2-values signals normal areas hearts removed during autopsy, subsequently fixed formalin, specimens sliced for preparation pathological specimens. Methods...
This study was performed primarily to clarify whether pathological analysis of cadavers for anatomical dissection is possible using postmortem imaging (PMI), and this worthwhile. A total 33 that underwent systematic at our medical school also PMI. Fixative solution injected into the corpus 3-4 days after death. PMI then an 8-slice multi-detector CT scanner 3 months before dissection. Before dissection, a conference held discuss findings First, two radiologists read images without any...
Abstract Monosodium urate (MSU) crystals are known to induce gouty arthritis, but also evoke specific cell immunity and work as an adjuvant by delivering several kinds of binding proteins, including idiotypic cancer vaccine peptides into dendritic cells. To investigate the potency MSU a carrier in vivo, this preclinical study examined whether intradermal injection was safe for healthy adults. Subjects comprised 12 volunteers. Four different dose levels were injected follows: 2 μg (n = 3), 20...