A5010494680- American Constitutional Law and Politics
- Colonialism, slavery, and trade
- Pluripotent Stem Cells Research
- Canadian Identity and History
- CRISPR and Genetic Engineering
- Historical Economic and Legal Thought
- American History and Culture
- American Environmental and Regional History
- 3D Printing in Biomedical Research
- Genomics and Chromatin Dynamics
- Australian History and Society
- Archaeology and Natural History
- Political and Economic history of UK and US
- Microfluidic and Bio-sensing Technologies
- Ubiquitin and proteasome pathways
- Multicultural Socio-Legal Studies
- Light effects on plants
- Legal principles and applications
- RNA Research and Splicing
- Reformation and Early Modern Christianity
- Plant Molecular Biology Research
- Circular RNAs in diseases
- Scottish History and National Identity
- European Political History Analysis
- Migration, Health, Geopolitics, Historical Geography
Walter and Eliza Hall Institute of Medical Research
2025
Peter MacCallum Cancer Centre
2022-2024
The University of Melbourne
2024
University of Copenhagen
2014-2023
Novo Nordisk Foundation
2017-2023
University of Edinburgh
2013
Mount Allison University
1986-1990
Western University
1975
Duke University
1946-1971
Abstract The epitranscriptome embodies many new and largely unexplored functions of RNA. A significant roadblock hindering progress in epitranscriptomics is the identification more than one modification individual transcript molecules. We address this with CHEUI (CH3 (methylation) Estimation Using Ionic current). predicts N6-methyladenosine (m6A) 5-methylcytosine (m5C) molecules from same sample, stoichiometry at reference sites, differential methylation between any two conditions. processes...
Fgf signaling via Erk activation has been associated with both neural induction and the generation of a primed state for differentiation embryonic stem cells (ESCs) to all somatic lineages. To dissect role in ESC self-renewal lineage specification, we explored requirements this pathway various vitro settings. A combination pharmacological inhibition genetic loss function reveal endodermal, but not differentiation. Neural occurs normally despite complete block phosphorylation. In support...
The question of what guides lineage segregation is central to development, where cellular differentiation leads segregated cell populations destined for specialized functions. Here, using optical tweezers measurements mouse embryonic stem cells, we reveal a mechanical mechanism based on differential elasticity in the second inner mass into epiblast (EPI) which will develop fetus, and primitive endoderm (PrE), form extraembryonic structures such as yolk sac. Remarkably, find that these...
Arthropods, the most diverse phylum on Earth, are hosts to a plethora of bacterial parasites that secrete various toxins unknown function during infection. The prevalent these is intracellular bacterium Wolbachia pipientis . microbe infects between 40-60% insect species, causes important reproductive manipulations, and limits virus replication in arthropod vectors, becoming promising biocontrol agent. Understanding molecular basis infection Wolbachia- induced phenotypes critical use vector...
Activation of the FGF-ERK pathway is necessary for naïve mouse embryonic stem (ES) cells to exit self-renewal and commit early differentiated lineages. Here we show that genetic ablation Erk2, predominant ERK isozyme expressed in ES cells, results hyper-phosphorylation ERK1, but an overall decrease total activity as judged by substrate phosphorylation immediate-early gene (IEG) induction. Normal induction this subset canonical targets, well p90RSK phosphorylation, was rescued transgenic...
The English People on the Eve of Colonization, 1603–1630. By Wallace Notestein. New American Nation Series. Edited by Henry Steele Commager and Richard B. Morris. (New York: Harper Brothers, 1954. xviii + 302 pp. Illustrations, maps, essay sources, index. $5.00.) Get access William Hamilton Duke University Search for other works this author on: Oxford Academic Google Scholar Journal History, Volume 41, Issue 4, March 1955, Pages 685–686, https://doi.org/10.2307/1889184 Published: 01 1955
IT IS NOT IMPOSSIBLE that an essay, in a literal sense of the word, on wellsprings, realities-dynamics is fashionable word-of politics small area might throw bit light general questions interest to students government. The formation political parties was precipitated Mississippi by transfer from one colonial power another-from Spain United States. Almost solely out local issues grew alignment which coincidentally fit two national I797. In Treaty San Lorenzo, had agreed evacuate Natchez...
Journal Article The Correspondence of George, Prince Wales 1770–1812 Get access 1770–1812. Volume II, 1789–1794. Edited by Aspinall A.. (New York: Oxford University Press. 1964. Pp. 559. $19.20.) W. B. Hamilton 1Duke Search for other works this author on: Academic Google Scholar American Historical Review, 71, Issue 1, October 1965, Pages 181–182, https://doi.org/10.1086/ahr/71.1.181-a Published: 01 1965