A5030870196- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Estrogen and related hormone effects
- Renal and related cancers
- Radiomics and Machine Learning in Medical Imaging
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- Urological Disorders and Treatments
- AI in cancer detection
- Photoacoustic and Ultrasonic Imaging
- Urologic and reproductive health conditions
- Mechanisms of cancer metastasis
- Thermography and Photoacoustic Techniques
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Pain Management
- Reconstructive Surgery and Microvascular Techniques
- Ultrasound and Hyperthermia Applications
- Protein Kinase Regulation and GTPase Signaling
- Pediatric Urology and Nephrology Studies
- Agriculture Sustainability and Environmental Impact
Medical College of Wisconsin
2016-2025
Medical College of Wisconsin Cancer Center
2019-2021
City Of Hope National Medical Center
2008
The University of Texas MD Anderson Cancer Center
2005-2007
The University of Texas Health Science Center at San Antonio
2007
The University of Texas Health Science Center at Houston
2006
This study aims to combine multiparametric magnetic resonance imaging (MRI) and digitized pathology with machine learning generate predictive maps of histologic features for prostate cancer localization.Thirty-nine patients underwent MRI prior prostatectomy. After surgery, tissue was sliced according orientation using patient-specific 3-dimensionally printed slicing jigs. Whole-mount sections were annotated by our pathologist digitally contoured differentiate the lumen epithelium. Slides...
To compare outcomes of minimally invasive radical nephrectomy (MIS-RN) and robot-assisted partial (RAPN) in clinical T2a renal mass (cT2aRM).Retrospective, multicentre, propensity score-matched (PSM) comparison RAPN MIS-RN for cT2aRM (T2aN0M0). Cohorts were PSM age, sex, body index, American Society Anesthesiologists (ASA) class, tumour size, R.E.N.A.L. score using a 2:1 ratio RN:PN. The primary outcome was disease-free survival (DFS). Secondary included overall (OS), complication rates, de...
We compared perioperative outcomes after on-clamp versus off-clamp robot-assisted partial nephrectomy (RAPN) for >7 cm renal masses. A multicenter dataset was queried patients who had undergone RAPN a cT2cN0cM0 kidney tumor from July 2007 to February 2022. The Trifecta achievement (negative surgical margins, no severe complications, and ≤ 30% postoperative estimated glomerular filtration rate (eGFR) reduction) considered surrogate of quality. Overall, 316 cases were included in the analysis,...
Prostate cancer is the most common noncutaneous in men United States. The current paradigm for screening and diagnosis imperfect, with relatively low specificity, high cost, morbidity. This study aims to generate new image contrasts by learning a distribution of unique signatures associated prostate cancer. In total, 48 patients were prospectively recruited this institutional review board–approved study. Patients underwent multiparametric magnetic resonance imaging 2 weeks before surgery....
Authors from the USA evaluated complication and survival rates in a large group of patients who had nephron‐sparing surgery or radical nephrectomy for locally advanced RCC. They found that highly selected with disease, is safe has equivalent outcomes to nephrectomy. OBJECTIVE To evaluate perioperative rates, recurrence‐free cancer‐specific (CSS) matched (NSS) (RN) pT2‐T3bN0M0 renal cell carcinoma (RCC). PATIENTS AND METHODS With approval institutional review board, database 3470 treated at...
Multiparametric magnetic resonance imaging (MP-MRI), including diffusion-weighted imaging, is commonly used to diagnose prostate cancer. This radiology-pathology study correlates cancer grade and morphology with common b-value combinations for calculating apparent diffusion coefficient (ADC). Thirty-nine patients undergoing radical prostatectomy were recruited MP-MRI prior surgery. Diffusion was collected seven b-values, ADC calculated. Excised prostates sliced in the same orientation as MRI...
Androgen receptor (AR) drives prostate cancer (PC) growth and progression, targeting AR signaling is the mainstay of pharmacological therapies for PC. Resistance develops relatively fast as a result refueled activity. A major gap in field lack understanding targetable mechanisms that induce persistent expression castrate-resistant PC (CRPC). This study uncovers an unexpected function active Stat5 signaling, known promoter clinical potent inducer gene transcription. suppression inhibited...
800 Background: Atezolizumab (A) has demonstrated single agent activity as neoadjuvant therapy (NAT) for muscle invasive urothelial carcinoma (MIUC) (ABACUS trial). Cabozantinib (C) a unique immunomodulatory profile that may foster anti-tumor immunity and clinical monotherapy in combination with A. We hypothesized the of C A NAT MIUC would improve pathologic response rate (pRR) compared to single-agent Methods: This open-label, arm, multi-center study investigated efficacy safety 40 mg PO...
Prostate cancer (PCa) is the most diagnosed non-cutaneous in men. Despite therapies such as radical prostatectomy, which considered curative, distant metastases may form, resulting biochemical recurrence (BCR). This study used radiomic features calculated from multi-parametric magnetic resonance imaging (MP-MRI) to evaluate their ability predict BCR and PCa presence. Data a total of 279 patients, 46 experienced BCR, undergoing MP-MRI prior surgery were assessed for this study. After surgery,...
Objectives: Stress urinary incontinence (SUI) is a known complication following prostatectomy. Duloxetine, combined serotonin/norepinephrine reuptake inhibitor, can decrease SUI by increasing urethral sphincter contractility. We examined the outcomes of patients with mild to moderate post-prostatectomy treated duloxetine.Methods: conducted retrospective review men duloxetine manage from 2006 2012. All received oral 30 mg once week, then 60 thereafter. Patients were seen one month later...
The second-generation antiandrogen, enzalutamide, is approved for castrate-resistant prostate cancer (CRPC) and targets androgen receptor (AR) activity in CRPC. Despite initial clinical activity, acquired resistance to enzalutamide arises rapidly most patients develop terminal disease. Previous work has established Stat5 as a potent inducer of growth. Here, we investigated the significance Jak2-Stat5 signaling enzalutamide. levels Jak2 mRNA, proteins activation were evaluated cells,...
Purpose: Our study predictively maps epithelium density in magnetic resonance imaging (MRI) space while varying the ground truth labels provided by five pathologists to quantify downstream effects of interobserver variability. Approach: Clinical and postsurgical tissue from 48 recruited prospective patients were used our study. Tissue was sliced match MRI orientation whole-mount slides stained digitized. Data 28 (n = 33 slides) sent be annotated. Slides remaining 20 123 annotated one...
Salvage radical prostatectomy is rare due to the risk of postoperative complications. We compare salvage Retzius-sparing robotic assisted (SRS-RARP) with standard (SS-RARP).A total 72 patients across 9 centers were identified (40 SRS-RARP vs 32 SS-RARP). Demographics, perioperative data, and pathological functional outcomes compared using Student's t-test ANOVA. Cox proportional hazard models Kaplan-Meier curves constructed assess incontinence time continence. Linear regression investigate...
Applying the thermoacoustic (TA) effect to diagnostic imaging was first proposed in 1980s. The object under test is irradiated by high-power pulses of electromagnetic energy, which heat tissue and cause thermal expansion. Outgoing TA pressure are detected ultrasound transducers reconstructed provide images object. contrast mechanism strongly dependent upon frequency irradiating pulse.
Background Diffusion‐weighted imaging (DWI) is commonly used to detect prostate cancer, and a major clinical challenge differentiating aggressive from indolent disease. Purpose To compare 14 site‐specific parametric fitting implementations applied the same dataset of whole‐mount pathologically validated DWI test hypothesis that cancer differentiation varies with different algorithms. Study Type Prospective. Population Thirty‐three patients prospectively imaged prior prostatectomy. Field...
No AccessJournal of UrologyAdult Urology: Oncology: Prostate/Testis/Penis/Urethra1 Oct 2005VALIDATION OF CRITERIA USED TO PREDICT EXTRAPROSTATIC CANCER EXTENSION: A TOOL FOR USE IN SELECTING PATIENTS NERVE SPARING RADICAL PROSTATECTOMY ASHISH M. KAMAT, KENNETH JACOBSOHN, PATRICIA TRONCOSO, Y.U. SHEN, SIJIN WEN, and R. JOSEPH BABAIAN KAMATASHISH KAMAT More articles by this author , JACOBSOHNKENNETH JACOBSOHN TRONCOSOPATRICIA TRONCOSO SHENY.U. SHEN WENSIJIN WEN BABAIANR. View All Author...
Introduction: Robotic-assisted radical cystectomy (RARC) is an emerging minimally invasive alternative for the treatment of bladder cancer. The V-loc (Covidien, Mansfield, MA) suture a unidirectional barbed that provides even distribution tension. We determined rate urinary leak at urethro-intestinal anastomosis following orthotopic neobladder construction performed with suture.Methods: retrospectively reviewed charts on all patients underwent RARC diversion from February 2010 to 2012. was...