A5070734807- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Immune Response and Inflammation
- Viral Infections and Vectors
- Advanced Glycation End Products research
- Malaria Research and Control
- Mosquito-borne diseases and control
- Neuroscience and Neuropharmacology Research
- Inflammasome and immune disorders
- Immune cells in cancer
- Nanoparticles: synthesis and applications
- IoT-based Smart Home Systems
- Telomeres, Telomerase, and Senescence
- Biometric Identification and Security
- Graphene and Nanomaterials Applications
- Cancer therapeutics and mechanisms
- Microtubule and mitosis dynamics
- interferon and immune responses
- QR Code Applications and Technologies
- Spaceflight effects on biology
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Advanced Nanomaterials in Catalysis
- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
The University of Texas Medical Branch at Galveston
2020-2024
ESIC Hospital
2020
ESI - Post Graduate Institute of Medical Science and Research
2020
Employees State Insurance Post Graduate Institute of Medical Sciences and Research
2020
Institute of Life Sciences
2017-2019
Dr. Hari Singh Gour University
2018
Indian Institute of Advanced Research
2015-2017
Sant Gadge Baba Amravati University
2013
Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College
2008-2012
Abstract: The interaction between silver nanoparticles and viruses is attracting great interest due to the potential antiviral activity of these particles, subject much research effort in treatment infectious diseases. In this work, we demonstrate that undergo a size-dependent with herpes simplex virus types 1 2 human parainfluenza type 3. We show production from different fungi feasible, their dependent on system used. Silver are capable reducing viral infectivity, probably by blocking...
Abstract Tau aggregates propagate in brain cells and transmit to neighboring as well anatomically connected regions by prion-like mechanisms. Soluble tau (tau oligomers) are the most toxic species that initiate neurodegeneration tauopathies, such Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), dementia with Lewy bodies (DLB). Exogenous have been shown be internalized cells; however, precise cellular molecular mechanisms underlie internalization of oligomers (TauO) remain...
Dengue is the most rapidly spreading viral disease transmitted by bite of infected Aedes mosquitos. The pathogenesis dengue still unclear; although host immune responses and virus serotypes have been proposed to contribute severity. In this study, we examined circulating (DENV) measured plasma levels inflammatory mediators. Ninety-eight patients during a outbreak in eastern India 2016 were included study. presence DENV was demonstrated detecting NS1 antigen; IgM capture ELISA discriminated...
Ubiquitin-modified tau aggregates are abundantly found in human brains diagnosed with Alzheimer's disease (AD) and other tauopathies. Soluble oligomers (TauO) the most neurotoxic species that propagate pathology elicit cognitive deficits, but whether ubiquitination contributes to formation spreading is not fully understood. Here, we observed K63-linked, K48-linked, ubiquitinated TauO accumulated at higher levels AD compared age-matched controls. Using mass spectrometry analyses, identified...
Pathological tau aggregates cause cognitive decline in neurodegenerative tauopathies, including Alzheimer’s disease (AD). These are prevalent within intracellular compartments. Current immunotherapies have shown limited efficacy clearing and improving cognition clinical trials. In this study, we developed toxic conformation–specific monoclonal antibody-2 (TTCM2), which selectively recognized pathological brain tissues from patients with AD, dementia Lewy bodies (DLB), progressive...
Microglia activation and neuroinflammation are key events during the progression of neurodegenerative disorders. exhibits toll-like receptors (TLRs), with predominant expression TLR4, inducing aberrant exacerbated neurotoxicity. Studies suggest that microglia initiate infiltration T cells into brain critically influence disease conditions. We report LPS-Rs, through TLR4 antagonism, significantly inhibit mediated inflammatory molecules like IL-1β, IL-6, TNF-α, COX-2, iNOS, NO. LPS-Rs...
Neuroinflammation following immune activation in the central nervous system (CNS) leads to neuronal loss specific areas of CNS resulting neurodegenerative disorders. Thus, fine tuning responses within brain is essential, because most diseases are associated with chronic inflammation, aberrant microglia that follows inappropriate T cell and polarization. Brain's cells, microglia, sensitized extrinsic intrinsic stimuli mediating neuroinflammation contributing removal pathogen/injurious...
Background: Dengue an endemic disease in most subtropical and tropical regions of the world is causing severe epidemics India. An alarming rise dengue has also been seen Mumbai, during recent years. Aim Objective: The study was conducted to know prevalence infection, based on laboratory rapid screening tests for IgM IgG antibodies confirmatory ELISA test seasonal variation clinical profile these cases. Material Method: A retrospective results suspected cases carried out a tertiary care...
Abstract Background High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein, which excessively released by glial cells during aging and Alzheimer’s Disease (AD). The extracellular HMGB1 serves as key initiator of neuroinflammation, linked to exacerbated cognitive impairments in AD. Importantly, ‐ the strongest risk factor for AD characterized chronic, low‐grade inflammation known inflammaging. Evidence suggests that senescent (SC) accumulate with are an apoptosis‐resistant,...
Abstract Background Pathological tau aggregates cause cognitive decline in neurodegenerative tauopathies, including Alzheimer’s disease (AD), and more abundant intracellular vs . extracellular compartments. However, current immunotherapies are slow ineffective at clearing aggregates. Method We developed toxic conformation–specific monoclonal‐antibody‐2–loaded micelles (TTCM2‐ms) that selectively recognize disease‐relevant brain tissues from patients with AD, progressive supranuclear palsy,...
Abstract Background Aging, tau pathology, and chronic inflammation in the brain play crucial roles neuroinflammation, synaptic loss, neurodegeneration, cognitive decline tauopathies, such as Alzheimer’s disease. However, molecular mechanisms that trigger aberrant inflammatory signaling tauopathies are poorly understood. Method We utilized tissues from tauopathy patients mouse models. Our study involved immunofluorescence microscopy biochemical assays to investigate role of nuclear HMGB1 DNA...
Abstract Background Dengue is the most rapidly spreading viral disease transmitted by bite of infected Aedes mosquitos. Pathogenesis dengue still unclear; although host genetic factors, immune responses and virus serotypes have been proposed to contribute severity. The development high-throughput methods allowed scale up capabilities identifying key markers inflammation. Since NS1 protein has reported activate cells towards enhanced inflammation through TLR2, we examined role a polymorphism,...
Aging, pathological tau oligomers (TauO) and chronic inflammation in the brain play a central role tauopathies, including Alzheimer's disease (AD) frontotemporal dementia (FTD). However, underlying mechanism of TauO-induced aging-related neuroinflammation remains unclear. We here show that TauO-associated astrocytes display senescence-like phenotype brains AD FTD patients. TauO exposure triggers astrocyte senescence through HMGB1 release inflammatory senescence-associated secretory (SASP),...