A5060581693- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Polymer composites and self-healing
- Organoboron and organosilicon chemistry
- Advanced Polymer Synthesis and Characterization
- Pickering emulsions and particle stabilization
- Luminescence and Fluorescent Materials
- Single-cell and spatial transcriptomics
- Polymer Nanocomposites and Properties
- Boron Compounds in Chemistry
- Cancer Genomics and Diagnostics
- Crystallography and molecular interactions
- Boron and Carbon Nanomaterials Research
- Synthesis and Catalytic Reactions
- Synthesis and characterization of novel inorganic/organometallic compounds
- Hydrogen Storage and Materials
- Synthesis and Properties of Aromatic Compounds
- Advanced Memory and Neural Computing
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Hybrid Renewable Energy Systems
- Chemical Reactions and Mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- Photochromic and Fluorescence Chemistry
- Advanced Chemical Physics Studies
Illumina (United States)
2024
Boston College
2014-2023
Selecta Biosciences (United States)
2023
Fluent (United States)
2023
Northwestern University
2018-2022
Chestnut Hill College
2015-2019
University of Oregon
2013-2014
California State University, Fullerton
2012
Current vitrimer technology uses only a handful of distinct reactions for cross-linking. New dynamic can diversify functionality and properties. In this paper, reversible cross-links formed by conjugate addition–elimination thiols with Meldrum’s acid derivative enable compression–remolding silicone elastomers. After 10 remolding cycles, there is no discernible deterioration mechanical properties (Young’s modulus, Tg, rubbery plateau E’), nor change in stress relaxation activation energy....
Current single-cell RNA-sequencing approaches have limitations that stem from the microfluidic devices or fluid handling steps required for sample processing. We develop a method does not require specialized devices, expertise hardware. Our approach is based on particle-templated emulsification, which allows encapsulation and barcoding of cDNA in uniform droplet emulsions with only vortexer. Particle-templated instant partition sequencing (PIP-seq) accommodates wide range emulsification...
The synthesis of two parental BN anthracenes, 1 and 2, was developed, their electronic structure reactivity behavior were characterized in direct comparison with all-carbon anthracene. Gas-phase UV-photoelecton spectroscopy studies revealed the following HOMO energy trend: anthracene, -7.4 eV; anthracene 1, -7.7 bis-BN -8.0 eV. λmax lower band UV-vis absorption spectrum is as follows: 356 nm; 359 357 nm. Thus, although stabilized increasing incorporation, HOMO-LUMO gap remains unchanged...
The least stable isomer of the parental BN naphthalene series has been synthesized in a simple four-step sequence. Its experimental electronic structure characterization via UV-PES, cyclic voltammetry, and UV–vis spectroscopy direct comparison with three other known isomers established two guiding principles for predicting structures acene compounds: (1) Orientational have similar HOMO–LUMO gaps. (2) For each pair orientational isomers, more thermodynamically compound lower HOMO energy....
The rate of stress relaxation in a vitrimer can be modulated by changing solely the structure cross-linker electrophile.
The composition of low-Tg n-butylacrylate-block-(acetoxyaceto)ethyl acrylate block polymers is investigated as a strategy to tune the properties dynamically cross-linked vinylogous urethane vitrimers. As proportion cross-linkable increased, thermorheological properties, structure, and stress relaxation evolve in ways that cannot be explained by increasing cross-link density alone. Evidence presented network connectivity defects such loops dangling ends are increased microphase separation....
The first synthesis of a tetracene BN isostere is reported. Comparison with its direct, all-carbon analogue reveals that the exhibits lower-lying HOMO and slightly larger optical HOMO–LUMO gap. While tetracenes are prone to photodecomposition, scaffold less light sensitive, owing in part much higher photoluminescence quantum yield. In context this family, we introduce simple guiding principles for predicting frontier orbital energies as function position unit within scaffold.
The photochemistry of 1,2-dihydro-1,2-azaborinine derivatives was studied under matrix isolation conditions and in solution. Photoisomerization occurs exclusively to the Dewar valence isomers upon irradiation with UV light (>280 nm) high quantum yield (46 %). Further photolysis (254 results formation cyclobutadiene an iminoborane derivative. thermal electrocyclic ring-opening reaction isomer back 1,2-dihydro-1-tert-butyldimethylsilyl-2-mesityl-1,2-azaborinine has activation barrier...
9a,9-BN anthracene was synthesized using a simple three-step sequence involving intramolecular electrophilic borylation of 2-benzylpyridines.
The coordination chemistry of the 1,2-BN-cyclohexanes 2,2-R2 -1,2-B,N-C4 H10 (R2 =HH, MeH, Me2 ) with Ir and Rh metal fragments has been studied. This led to solution (NMR spectroscopy) solid-state (X-ray diffraction) characterization [Ir(PCy3 )2 (H)2 (η(2) η(2) -H2 BNR2 C4 H8 )][BAr(F) 4 ] (NR2 =NH2 , NMeH) [Rh(iPr2 PCH2 CH2 PiPr2 )(η(2) NMeH, NMe2 ). For NR2 subsequent metal-promoted, dehydrocoupling shows eventual formation cyclic tricyclic borazine [BNC4 ]3 via amino-borane and,...
Abstract The BN analogue of ortho ‐benzyne, 1,2‐azaborine, is shown to bind carbon monoxide and a xenon atom under matrix isolation conditions, demonstrating its strongly Lewis acidic superelectrophilic nature. acid–base complexes involving CO Xe can be cleaved photochemically reformed by mildly annealing the matrices. interaction energy 1,2‐azaborine with 3 kcal mol −1 according quantum chemical computations, similar that carbene difluorovinylidene.
Abstract The photochemistry of 1,2‐dihydro‐1,2‐azaborinine derivatives was studied under matrix isolation conditions and in solution. Photoisomerization occurs exclusively to the Dewar valence isomers upon irradiation with UV light (>280 nm) high quantum yield (46 %). Further photolysis (254 results formation cyclobutadiene an iminoborane derivative. thermal electrocyclic ring‐opening reaction isomer back 1,2‐dihydro‐1‐ tert ‐butyldimethylsilyl‐2‐mesityl‐1,2‐azaborinine has activation...
We describe the synthesis of MeH2N–BH2Me (3) and H3N–BH2Me (4) as potential hydrogen storage materials with 6.8 wt-% 8.9 capacity, respectively. Compounds 3 4 readily release 2 equivalents H2 at 80°C in presence a CoCl2 catalyst to furnish corresponding trimerized borazine derivatives. Regeneration from its spent fuel material can be accomplished using simple two-step process: activation formic acid followed by reduction LiAlH4.
Abstract Single-cell RNA sequencing is now a standard method used to reveal the molecular details of cellular heterogeneity, but current approaches have limitations on speed, scale, and ease use that stem from complex microfluidic devices or fluid handling steps required for sample processing. We, therefore, developed does not require specialized devices, expertise, hardware. Our approach based particle-templated emulsification, which allows single-cell encapsulation barcoding cDNA in...
The kinetics of reactions α-pinene and β-pinene with hydroxyl radicals (OH) has been investigated at 1–8 Torr 240–340 K using the relative rate/discharge flow/mass spectrometry (RR/DF/MS) technique. Our kinetic results indicate that 298 rate constant little pressure dependence over range, suggesting high limit these reached 1 Torr. was found to negatively depend on temperature K, which is consistent previous investigations different techniques. Arrhenius equation for radical determined be...
ABSTRACT Particle-templated instant partition sequencing (PIPseq), is an emerging approach for massively scalable single-cell gene expression studies that does not require complex instrumentation or expensive consumables. We present PIPseq TM V, a novel implementation of the workflow with significant improvements in assay performance and sensitivity compared to prior methods. Among innovations driving improved V new transcript counting using Intrinsic Molecular Identifiers (IMIs) from...
Mixtures of hydrogen storage materials are examined to find a ‘fuel blend’ that remains liquid phase throughout release, maximizes density, minimizes impurities and is thermally stable.
The first aromatic Claisen rearrangement of a 1,2-azaborine is described along with quantitative kinetic comparison the reaction azaborine its direct all-carbon analogue. A rearranged in clean, regioselective fashion and reacted faster than substrate B at all temperatures from 140-180 °C. Activation free energies were extracted observed first-order rate constants (A: Δ
Abstract Das BN‐Analogon des ortho ‐Benzins, 1,2‐Azaborin, bindet Kohlenmonoxid und ein Xenonatom unter den Bedingungen der Matrixisolation, was seine hohe Lewis‐Acidität Superelektrophilie zeigt. Die Lewis‐Säure‐Base‐Komplexe mit CO Xe können photochemisch gespalten werden bilden sich beim leichten Erwärmen Matrizes zurück. Bindungsenergie zwischen 1,2‐Azaborin beträgt nach quantenchemischen Untersuchungen 3 kcal mol −1 , ähnlich Xe‐Komplexes superelektrophilen Carbens Difluorvinyliden.
Vitrimers are a class of covalent adaptable networks (CANs) that undergo topology reconfiguration via associative exchange reactions, enabling reprocessing at elevated temperatures. Here, we show the use an mechanism additionally enables decoupling stiffness and stress relaxation. Guided by calculated activation barriers, prepared series cross-linkers with varying reactivity for conjugate addition–elimination thiols in PDMS vitrimer, demonstrate modulation relaxation rate while maintaining...
The composition of low-T g n -butylacrylate- block -(acetoxyaceto)ethyl acrylate polymers is investigated as a strategy to tune the properties dynamically cross-linked vinylogous urethane vitrimers. As proportion cross-linkable increased, thermorheological properties, structure, and stress relaxation evolve in ways that cannot be explained by increasing cross-link density alone. Evidence presented network connectivity defects such loops dangling ends are increased microphase separation....
<p>The composition of low-T<sub>g</sub> <i>n</i>-butylacrylate-<i>block</i>-(acetoxyaceto)ethyl acrylate block polymers is investigated as a strategy to tune the properties dynamically cross-linked vinylogous urethane vitrimers. As proportion cross-linkable increased, thermorheological properties, structure, and stress relaxation evolve in ways that cannot be explained by increasing cross-link density alone. Evidence presented network connectivity...