A5061098803- Advanced Breast Cancer Therapies
- Palliative Care and End-of-Life Issues
- HER2/EGFR in Cancer Research
- Prostate Cancer Treatment and Research
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Treatments and Mutations
- PARP inhibition in cancer therapy
- PI3K/AKT/mTOR signaling in cancer
- BRCA gene mutations in cancer
- Cancer Treatment and Pharmacology
- DNA Repair Mechanisms
- Advances in Oncology and Radiotherapy
- Cancer survivorship and care
- Economic and Financial Impacts of Cancer
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Chemotherapy-related skin toxicity
- Pain Management and Opioid Use
- Radiopharmaceutical Chemistry and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Patient Dignity and Privacy
- Methemoglobinemia and Tumor Lysis Syndrome
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
Mayo Clinic in Arizona
2011-2021
Mayo Clinic
2009-2019
University of Alabama at Birmingham
2016
Baylor College of Medicine
2016
WinnMed
2004-2011
Dartmouth–Hitchcock Medical Center
2010
Scripps Clinic
2010
Baystate Medical Center
2010
University of North Carolina at Chapel Hill
2010
San Diego Hospice and The Institute for Palliative Medicine
2008
Abstract Purpose: Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor–positive (ER+) breast cancer. This single-arm phase II neoadjuvant trial (NeoPalAna) assessed the antiproliferative activity of CDK4/6 inhibitor palbociclib primary cancer as a prelude to adjuvant studies. Experimental Design: Eligible patients with clinical stage II/III ER+/HER2− received anastrozole 1 mg daily for 4 weeks (cycle 0; goserelin if premenopausal), followed by adding (125 on days...
Evidence-based treatments for metastatic, human epidermal growth factor receptor 2 (HER2)-positive breast cancer to the CNS are limited. We previously reported modest activity of neratinib monotherapy HER2-positive brain metastases. Here we report results from additional study cohorts.Patients with measurable, progressive, metastases (92% after receiving surgery and/or radiotherapy) received 240 mg orally once per day plus capecitabine 750 mg/m2 twice 14 days, then 7 days off....
Abstract BACKGROUND. Primary cardiac sarcomas are uncommon. The authors undertook to review the Mayo Clinic's experience with primary consisting of 34 patients seen over a 32‐year period. METHODS. patient database at Clinic was searched identify malignant tumors heart during period between 1975 and 2007. Thirty‐four were identified their medical records reviewed for details pertaining presenting symptoms, staging modalities, treatment approaches, outcomes. RESULTS. Of patients, 17 men women....
PURPOSE This prospective randomized cooperative group study was conducted in patients with neoplastic meningitis treated intrathecal methotrexate or thiotepa to assess response rates and survival, prognostic factors, the toxicity of these regimens. PATIENTS AND METHODS Fifty-nine adults nonleukemic malignancies, performance status 0 3, positive CSF cytologies were assigned receive (10 mg) twice weekly. Radiation, administered mass lesions and/or symptomatic sites appropriate systemic therapy...
<h3>Importance</h3> Most patients with advanced-stage cancer develop impairment and pain-driven functional losses that jeopardize their independence. <h3>Objective</h3> To determine whether collaborative telerehabilitation pharmacological pain management improve function, lessen pain, reduce requirements for inpatient care. <h3>Design, Setting, Patients</h3> The Collaborative Care to Preserve Performance in Cancer (COPE) study was a 3-arm randomized clinical trial conducted at 3 academic...
Abstract Purpose: We aimed to establish the MTD of poly (ADP-ribose) (PAR) polymerase inhibitor, veliparib, in combination with carboplatin germline BRCA1- and BRCA2- (BRCA)-associated metastatic breast cancer (MBC), assess efficacy single-agent treatment after progression, correlate PAR levels clinical outcome. Experimental Design: Phase I patients received (AUC 5–6, every 21 days), escalating doses (50-20 mg) oral twice-daily (BID) veliparib. In a companion phase II trial, veliparib (400...
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Abstract Purpose: Hyperactivation of AKT is common and associated with endocrine resistance in estrogen receptor–positive (ER+) breast cancer. The allosteric pan-AKT inhibitor MK-2206 induced apoptosis PIK3CA-mutant ER+ cancer under estrogen-deprived condition preclinical studies. This neoadjuvant phase II trial was therefore conducted to test the hypothesis that adding anastrozole induces pathologic complete response (pCR) PIK3CA mutant Experimental Design: Potential eligible patients...
Fourteen patients with advanced gastric adenocarcinpma were treated continuous 5-fluorouracil (5-FU) infusion, 300 mg/m2/day, through an indwelling central venous catheter; 13 evaluable for response. The results as follows: Partial remission was seen in 4 of (31%), stable disease 5 (38%), and progressive (31%). median duration response 19 weeks (range, 10–41), the survival all from initiation infusion 27 9–54). Treatment interruption and/or dosage attenuation toxicity necessary 7 14 (50%);...
The increasingly competitive health care environment may undermine effective traditional regional organizations. It is urgent to document the benefits of perinatal regionalization for emerging system. We present a case study that illustrates many challenges and in 1990s.The controversy Hartford was sparked by proposed merger two major pediatric services into full-service children's hospital. Community hospitals reacted with plans upgrade their obstetrics/neonatal facilities toward level II...
We sought to characterize the aggregate features and survival of patients who receive inpatient palliative care consultation, particularly focusing on with cancer, identify opportunities improve clinical outcomes.We reviewed prospectively collected data seen by Palliative Care Inpatient Consult Service at Mayo Clinic (Rochester, MN) from January 2003 September 2008. Demographics, consultation characteristics, were analyzed using Kaplan-Meier curves Cox models.Cancer was most common primary...