A5069037609- Schizophrenia research and treatment
- Pharmacogenetics and Drug Metabolism
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Cardiac electrophysiology and arrhythmias
- Diet and metabolism studies
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Health and Mental Health
- Blood Pressure and Hypertension Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Tryptophan and brain disorders
- Intensive Care Unit Cognitive Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Poisoning and overdose treatments
- Blood disorders and treatments
- Electrolyte and hormonal disorders
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- Cardiovascular Syncope and Autonomic Disorders
St. Michael's Hospital
2025
The University of Texas Health Science Center at San Antonio
2002-2025
United Christian Hospital
2022
The University of Texas at Austin
1990-2019
Austin College
1990-2019
Tzu Chi University
2001
St George's Hospital
1999
Audie L. Murphy Memorial VA Hospital
1996
University of North Carolina at Chapel Hill
1995
Bali Psychiatric Center
1994
The most common ways of assessing adherence to oral antipsychotic medications in research and clinical practice are self-report physician report. This prospective study examined the agreement among measures 52 outpatients with schizophrenia.Participants were assessed at baseline during a visit their outpatient clinic followed for 12 weeks. Adherence was by using subjective (self-report report) objective (pill counts conducted home, electronic monitoring, blood plasma concentrations)....
The authors report the CYP2D6 inhibitory effects of fluoxetine, paroxetine, sertraline, and venlafaxine in an open‐label, multiple‐dose, crossover design. Twelve extensive metabolizers were phenotyped, using dextromethorphan/dextrorphan (DM/DX) urinary ratio, before after administration fluoxetine 60 mg (loading dose strategy), paroxetine 20 mg, sertraline 100 150 mg. Paroxetine, sequences randomized with 2‐week washouts between treatments; was last antidepressant (AD) administered....
The objective of this study was to investigate pharmacokinetic and pharmacodynamic interactions between midazolam fluoxetine, fluvoxamine, nefazodone, ketoconazole. Forty healthy subjects were randomized receive one the four drugs for 12 days in a parallel design: fluoxetine 60 mg per day 5 days, followed by 20 7 days; fluvoxamine titrated daily dose 200 mg; nefazodone 400 or ketoconazole day. All 40 received oral solution before after 12‐day drug regimen. Blood samples determination...
The aim of this study was to evaluate the CYP2D6 inhibitory effects four selective serotonin reuptake inhibitors (SSRIs).Thirty-one healthy subjects were phenotyped as extensive metabolizers using dextromethorphan/dextrorphan (DM/DX) urinary ratio a marker for activity before and after 8 days administration fluoxetine 60 mg (loading dose strategy), fluvoxamine 100 mg, paroxetine 20 or sertraline in parallel-group design. Statistical analysis performed on log-transformed DM/DX ratios because...
The mapping of the human genome and subsequent advancements in genetic technology had provided clinicians scientists an understanding basis altered drug pharmacokinetics pharmacodynamics, as well some examples applying genomic data clinical practice. This has raised public expectation that predicting patients’ responses to therapy is now possible every therapeutic area, personalized would come sooner than later. However, debate continues among most stakeholders involved development...
Study Objective. To assess the correlation between plasma concentrations of four commonly administered selective serotonin reuptake inhibitors (SSRIs) and magnitude cytochrome P450 (CYP) 2D6 inhibition. Design. Prospective analysis. Setting. University‐affiliated research laboratory. Patients. Thirty‐two healthy, drug‐free volunteers. Intervention. Subjects were randomized to groups received daily administration either fluoxetine 60 mg (as a loading dose), fluvoxamine 100 mg, paroxetine 20...
Abstract Objectives Electronic health records (EHRs) data are increasingly used for research and analysis, but there is little empirical evidence to inform how automated manual assessments can be combined efficiently assess quality in large EHR repositories. Materials Methods The GEMINI database collected from 462 226 patient admissions across 32 hospitals 2021 2023. We report issues identified through semi-automated completed during the collection phase. conducted a simulation experiment...
Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug with a low incidence of severe adverse reactions. It metabolized by oxidation to carboxyibuprofen and hydroxyibuprofen conjugation acyl glucuronide. In vitro studies have indicated that ibuprofen glucuronide labile reactive, forming covalent adducts proteins. To verify the formation ibuprofen-protein in vivo, pharmacokinetics its binding plasma proteins were studied five elderly patients who received long-term...
Use of psychotropic drugs, especially but not only most second‐generation antipsychotics, is associated with higher levels lipids, posing an increased risk for developing cardiovascular disease (Pillinger et al., 2020). There also evidence that plasma lipid and dyslipidemia are substantially impacted by clinical genetic factors (Ramasamy, 2016).
Research suggests that shortening of telomeres, protective cap‐like structures at the ends chromosomes, as well inflammation, are associated with decreased cellular lifespan, and such have been implicated in several age‐related medical conditions (Gavia‐García et al., 2021). A meta‐analysis has reported an association between shorter telomere length psychiatric conditions, including anxiety, bipolar disorder, depression, post‐traumatic stress psychosis (Darrow 2016).
It is not uncommon for patients to exhibit depressive symptoms after suffering a stroke. The research literature regarding the effect of antidepressants on stroke outcome and/or recurrence conflicting, however (Kalbouneh et al. 2022; Lundström 2020).
To establish the usefulness of fluorescence detection to quantify urinary concentrations dextromethorphan and dextrorphan for oxidation phenotyping, we determined molar concentration ratio in 38 subjects by UV detection. Dextromethorphan were quantified after overnight hydrolysis urine samples organic solvent extraction with heptane butanol. The compounds separated high-performance liquid chromatography using a phenyl column mobile phase consisting acetonitrile an aqueous mixture 0.01 M...
The oral route is compromised for nearly all patients approaching death. When agitation, seizures, or other intractable symptoms occur, a quick, discreet, comfortable, and effective alternate medication delivery that easy to administer in the home setting highly desirable.To characterize early absorption profile, variability, comfort of phenobarbital given microenema suspensions delivered via Macy Catheter(®) (MC) vs. same dose suppository.This was randomized, open-label, crossover study...
The disposition of the atypical clozapine and its desmethyl metabolite were evaluated in fourteen male chronic patients. A single 100 mg dose was administered blood sampling performed over following 72 hours. mean (SD) oral clearance half‐life 55.4 (29.7) L/hr 13.7 (9.9) hours, respectively. AUC for desmethylclozapine 2389.9 (1406) 751.1 (622.9) ng ·; hr/mL, elimination is rate limited by formation from cloza‐pine. wide interpatient variability pharmacokinetics observed.