A5032807196- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Viral Infections and Outbreaks Research
- Rabies epidemiology and control
- Viral Infections and Vectors
- Fungal Infections and Studies
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- HIV/AIDS Research and Interventions
- Antifungal resistance and susceptibility
- Infectious Diseases and Mycology
- Amoebic Infections and Treatments
- Travel-related health issues
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- HIV, Drug Use, Sexual Risk
- Pneumonia and Respiratory Infections
- Microscopic Colitis
- Migration, Health and Trauma
- Actinomycetales infections and treatment
- Nail Diseases and Treatments
San Diego State University
2011-2020
United States Customs and Border Protection
2020
Arizona Department of Health Services
2017
Maricopa County Department of Public Health
2017
National Center for Immunization and Respiratory Diseases
2017
Centers for Disease Control and Prevention
2007-2014
Epidemic Intelligence Service
2007-2014
Faculty of Public Health
2014
Naval Medical Center San Diego
2003-2012
National Center for Emerging and Zoonotic Infectious Diseases
2010-2012
Coccidioidomycosis is a fungal disease with protean manifestations endemic to the Lower Sonoran Life Zone, which includes hot deserts of southwestern United States and areas Mexico. Two hundred twenty-three patients were found have coccidioidomycosis at our institution from 1994-2002, largest reported cohort since 1950s. Of these patients, 58% presented isolated pulmonary disease, 14% had high (>1:16) complement fixation titers without clear evidence dissemination, 22% definite disseminated...
Background. We report the first confirmed case of eczema vaccinatum in United States related to smallpox vaccination since routine was discontinued 1972. A 28-month-old child with refractory atopic dermatitis developed after exposure his father, a member US military who had recently received vaccine. The father history inactive but reportedly reacted normally child's mother also contact vaccinia infection.
An outbreak of Rift Valley fever (RVF) occurred in Kenya during November 2006 through March 2007. We characterized the magnitude disease surveillance and serosurveys, investigated contributing factors to enhance strategies for forecasting prevent or minimize impact future outbreaks. Of 700 suspected cases, 392 met probable confirmed case definitions; demographic data were available 340 (87%), including 90 (26.4%) deaths. Male cases more likely die than females, Case Fatality Rate Ratio 1.8...
A large Rift Valley fever (RVF) outbreak occurred in Kenya from December 2006 to March 2007. We conducted a study define risk factors associated with infection and severe disease. total of 861 individuals 424 households were enrolled. Two hundred two participants (23%) had serologic evidence acute RVF infection. Of these, 52 (26%) disease characterized by hemorrhagic manifestations or death. Independent for consuming handling products sick animals (odds ratio [OR] = 2.53, 95% confidence...
Progressive vaccinia (PV) is a rare but potentially lethal complication that develops in smallpox vaccine recipients with severely impaired cellular immunity. We describe patient PV who required treatment immune globulin and received 2 investigational agents, ST-246 CMX001. the various molecular, pharmacokinetic, immunologic studies provided guidance to escalate then successfully discontinue therapy. Despite development of resistance during treatment, had resolution PV. This case...
BackgroundSkin disorders are common in travelers. Knowledge of the relative frequency post-travel-related skin disorders, including their geographic and demographic risk factors, will allow for effective pre-travel counseling, as well improved post-travel diagnosis therapeutic intervention.MethodsWe performed a retrospective study using anonymous patient demographic, clinical, travel-related data from GeoSentinel Surveillance Network clinics January 1997 through February 2006. The...
Background. Clostridium difficile infection (CDI) has increased in frequency and severity over the past decade. An understanding of modifiable risk factors for disease considerable clinical applicability. Methods. We performed a retrospective case review 485 cases patients aged 1–99 years at Naval Medical Center San Diego from November 2004 through December 2008. compared potential association with complications (megacolon, surgery, intensive care unit stay, death) or mortality alone use...
In September 2006, the Centers for Disease Control and Prevention was notified of cases gram-negative bloodstream infection (BSI) occurring among outpatients who received an intravenous formulation prostanoid treprostinil. An investigation conducted to determine rates prostanoid-associated BSI in this patient population possible risk factors infection.We performed a retrospective cohort study patients had formulations at least 1 2 approved prostanoids (epoprostenol treprostinil) from January...
Sets of Giemsa-stained, blood smear slides with systematically verified composite diagnoses would contribute substantially to development externally validated quality assurance systems for the microscopic diagnosis malaria. whole from Plasmodium-positive donors in Cambodia and Indonesia individuals no history risk malaria was collected. Using standard operating procedures, technicians prepared Giemsa-stained thick thin smears each donor. One slide first 35 donations distributed 28...
<h3>Background</h3> Rapidly growing mycobacteria (RGM) can cause a variety of cutaneous and systemic diseases. The causative organisms are typically<i>Mycobacterium fortuitum</i>or<i>Mycobacterium chelonae</i>(also known as<i>Mycobacterium abscessus</i>). Primary lesions may develop after variable latent period, from weeks to several months, usually result direct inoculation trauma, injections, or during surgery via contaminated medical instruments. Recently, investigators the Centers for...
Orf virus leads to self-limited, subacute cutaneous infections in children who have occupational or recreational contact with infected small ruminants. Breaches the integument and animals recently vaccinated for orf may be important risk factors transmission. Common childhood behaviors are likely provocation of significant (ie, bites) unusual lesion location (eg, facial lesions). Clinician recognition is distinguishing infection from life-threatening zoonoses. Recently developed molecular...
Orf virus is a parapoxvirus that infects small ruminants worldwide. We present the case report of 73-year-old woman with non-Hodgkins lymphoma who developed progressive orf lesions were unresponsive to surgical debridement and cidofovir therapy. The patient's infection was successfully treated topical imiquimod despite progression her malignancy.
Monkeypox virus is a zoonotic orthopoxvirus (OPX) of west and central sub-Saharan Africa. We conducted cross-sectional serosurvey in Likouala region, Republic Congo to assess exposure OPX. Whole blood was collected using Nobuto filter strips (NBFS). Titers IgM IgG OPX were assessed an enzyme-linked immunosorbent assay. Demographic clinical characteristics compared with serostatus the chi-square test or Fisher’s exact test. Multivariate logistic regression performed evaluate factors for...
The Pediatric Infectious Disease Journal: September 2009 - Volume 28 Issue 9 p 800 doi: 10.1097/INF.0b013e3181b18ed0
Rift Valley fever (RVF) is an important viral zoonotic disease in Africa with periodic outbreaks associated severe disease, death, and economic hardship. During the 2006-2007 Eastern Africa, postmortem necropsy tissue samples from 14 animals 20 humans clinically suspected of RVF were studied histopathologic evaluation immunohistochemical (IHC) assays. Six animal 11 human had IHC evidence virus (RVFV) antigens. We found that extensive hepatocellular necrosis without prominent inflammatory...
Application of molecular diagnostic methods to the determination etiology in suspected poxvirus-associated infections bovines is important both for diagnosis individual case and form a more complete understanding patterns strain occurrence spread. The objective this study was identify characterize bovine-associated zoonotic poxviruses Bangladesh which are relevant animal human health.Investigators from International Center Diarrhoeal Disease Research (icddr,b), US Centers Control Prevention...
To determine the extent and scope of outbreak skin eruptions, to identify causes acute diseases, risk factors for conditions, reduce dermatologic morbidity among workers repairing buildings damaged by Hurricane Katrina Rita.Retrospective cohort study.Military base in New Orleans, Louisiana.Civilian construction living working at a Orleans military between August 30, 2005, October 3, 2005. Living conditions were mainly wooden huts tents with limited sanitation facilities.Survey factors,...
Summary Orf virus, pseudocowpox virus and bovine papular stomatitis are parapoxviruses, associated with domestic ruminants, which capable of causing cutaneous infections in humans. Owing to virtually identical appearances humans, clinical differentiation these viruses is difficult. We discuss three recent occurrences parapoxvirus infection, involving contact use a combination molecular epidemiological data the diagnosis. These cases underscore utility modern diagnostic tools, along...