A5028916660- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Ovarian function and disorders
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Vitamin D Research Studies
- Cardiovascular Disease and Adiposity
- Thermoregulation and physiological responses
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Menopause: Health Impacts and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Estrogen and related hormone effects
- Cannabis and Cannabinoid Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diet, Metabolism, and Disease
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Renin-Angiotensin System Studies
- Heart Rate Variability and Autonomic Control
- Spaceflight effects on biology
- Atherosclerosis and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
Semmelweis University
2015-2025
Istituto Superiore di Sanità
2018
Hungarian Academy of Sciences
2012
Houston Methodist
2012
Phoenix VA Health Care System
2001
University of Pennsylvania
1981-1990
Both hyperandrogenism (HA) and vitamin D deficiency (VDD) can separately lead to impaired vascular reactivity ovulatory dysfunction in fertile females. The aim was examine the early interactions of these states a rat model PCOS. Four-week-old adolescent female rats were divided into four groups: (VD)-supplemented (n = 12); VD-supplemented testosterone-treated VDD- 11) VDD-and-testosterone-treated 11). Animals underwent transdermal testosterone treatment for 8 weeks. Target VD levels achieved...
To clarify the mechanism leading to development and rupture of intracranial aneurysms, tensile strength viscoelastic parameters 22 human saccular aneurysms were investigated. Meridional circumferential strips from thin thick part aneurysm sack 18 control basilar artery 8 patients with pathologies not affecting cerebral arterial system studied. The length was increased in 200-µm steps, while distending force recorded. Tensile computed. In both directions, significantly lower than that...
Angiotensin II (Ang II) is a major regulator of steroidogenesis in adrenocortical cells, and also an effective inducer cytokine growth factor synthesis several cell types. In microarray analysis H295R human the mRNA brain-derived neurotrophic (BDNF), neurotrophin widely expressed nervous system, was one most up-regulated genes by Ang II. The aim present study II-induced BDNF expression BDNF-induced effects cells. Real-time PCR studies have shown that rat adrenal glomerulosa kinetics faster...
Hyperandrogenic state in females is accompanied with metabolic syndrome, insulin resistance and vascular pathologies. A total of 67%-85% hyperandrogenic women suffer also from vitamin D deficiency. We aimed to check a potential interplay between hyperandrogenism deficiency producing effects on coronary arteries. Adolescent female rats were divided into four groups, 11-12 animals each. Transdermal testosterone-treated vehicle-treated kept either D-deficient or D-supplemented diet for 8 weeks....
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism and insulin resistance, both of which have been connected to atherosclerosis. Indeed, an increased risk clinical manifestations arterial vascular diseases has described in PCOS. On the other hand endothelial dysfunction can be detected early on, before atherosclerosis develops. Thus we assumed that also related directly hormonal imbalance rather than its metabolic consequences. To detect...
Vitamin D deficiency (VDD) is a global health problem, which can lead to several pathophysiological consequences including cardiovascular diseases. Its impact on the cerebrovascular system not well understood. The goal of present work was examine effects VDD morphological, biomechanical and functional properties cerebral arterioles.Four-week-old male Wistar rats (n = 11 per group) were either fed with vitamin deficient diet or received conventional rat chow os supplementation. Cardiovascular...
Hyperandrogenism is a risk factor of cerebrovascular diseases as androgens can alter markedly the regulation tone. We examined combined impact androgen excess and vitamin D deficiency (VDD), common co-morbidity in hyperandrogenic disorders, on remodeling testosterone-induced vascular responses anterior cerebral arteries (ACA) order to evaluate interplay between VDD vasculature. Male female Wistar rats were either fed with deficient or supplemented diet. Half animals from both groups received...
We aimed to examine the alterations of insulin signaling pathway, autophagy, nitrative stress and effect vitamin D supplementation in liver ovaries deficient hyperandrogenic rats.Female Wistar rats received eight weeks transdermal testosterone treatment lived on a low diet (D-T+). Vitamin was achieved by oral administration D3 (D+T+). Sham-treated (D+T-) animals (D-T-) served as controls. (N = 10-12 per group).D-T+ showed decreased LC3 II levels increased p-Akt/Akt p-eNOS/eNOS ratios with...
Angiotensin II (Ang II) has various cardiac effects and causes vasoconstriction. Ang activates the type-1 angiotensin receptor—Gq/11 signaling pathway resulting in release of 2-arachidonoylglycerol (2-AG). We aimed to investigate whether are modulated by 2-AG-release identify role cannabinoid receptors (CB1R) these effects. Expression CB1R rat tissue was confirmed immunohistochemistry. To characterize short-term effects, increasing concentrations (10−9–10−7 M); whereas assess tachyphylaxis,...
Hypercholesterolemia forms the background of several cardiovascular pathologies. LDL receptor-knockout (LDLR-KO) mice kept on a high-fat diet (HFD) develop high cholesterol levels and atherosclerosis (AS). Cannabinoid type 1 receptors (CB1Rs) induce vasodilation, although their role in pathologies is still controversial. We aimed to reveal effects CB1Rs vascular function remodeling hypercholesterolemic AS-prone LDLR-KO mice. Experiments were performed newly established LDLR CB1R...
Infertility is increasing worldwide; male factors can be identified in nearly half of all infertile couples. Histopathologic evaluation testicular tissue provide valuable information about infertility; however, several different methods and semi-quantitative score systems exist. Our goal was to describe a new, accurate easy-to-use quantitative computer-based histomorphometric-mathematical image analysis methodology for the tissue. On digitized, original hematoxylin-eosin (HE)-stained slides...
The myogenic response, an active constriction and dilation of vessels to changes in intravascular pressure, can play important role the regulation coronary blood flow. characteristics response its modulation by endothelium-derived factors are organ location specific have not been studied extensively intramural arterioles. Thus, distal branches (approximately 100 approximately 170 microm passive diameter, respectively) left anterior descending artery rats were isolated cannulated. Step...
<b><i>Purpose:</i></b> Exercise elicits early adaptation of coronary vessels enabling the circulation to respond adequately higher flow demands.<b><i></i></b> We hypothesized that short-term daily exercise induces biomechanical and functional remodeling resistance arteries related pressure. <b><i>Methods:</i></b> Male rats were subjected a progressively increasing 4-week treadmill program (over 60 min/day, 1 mph in final...
Objective To determine the effects of oestrogen deficiency and hormone replacement therapy on biomechanical properties a small artery. Sample Thirty non‐pregnant female Sprague‐Dawley rats. Methods Twenty animals were pharmacologically ovariectomised by triptorelin received either oestradiol propionate or its vehicle. Ten other only vehicle for same period time (control group). After 12 weeks treatment, cylindrical segments saphenous artery isolated cannulated at both ends. Pressure‐diameter...
We hypothesized that because of their size, anatomic location, and hemodynamic function, coronary arteries arterioles would respond differently to vasoactive substances. Intramural (281.7 ± 23.1 μm) (77.3 6.6 the left anterior descending rats were isolated cannulated. Spontaneous tone was lower in than (81.1 5.7 vs. 53.0 3.9% passive diameter, p < 0.05 at 60 mm Hg intraluminal pressure). Arterial adjusted by thromboxane receptor agonist U46619 (5 × 10 −8M) reach an active close arterioles....