A5015184747- Acute Ischemic Stroke Management
- Autoimmune Neurological Disorders and Treatments
- T-cell and B-cell Immunology
- Adipokines, Inflammation, and Metabolic Diseases
- Peripheral Neuropathies and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Dysphagia Assessment and Management
- Nutrition and Health in Aging
- Cerebrovascular and Carotid Artery Diseases
- Cerebral Venous Sinus Thrombosis
- GDF15 and Related Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Circular RNAs in diseases
- Clinical Nutrition and Gastroenterology
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Inflammation biomarkers and pathways
- Infectious Encephalopathies and Encephalitis
- Medical Research and Treatments
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Stroke Rehabilitation and Recovery
- MicroRNA in disease regulation
Union Hospital
2021-2025
Huazhong University of Science and Technology
2018-2025
Union Hospital
2018
Abstract Phenotypic switching of vascular smooth muscle cells (VSMCs) is essential for atherosclerosis development. Circular RNA (circRNA) a specific non‐coding that produced as closed‐loop structure in mammals, and its expression pattern closely related to cell type tissue. To clarify the roles circTLK1 VSMC phenotypic switching, we performed qRT‐PCR, immunoblotting, immunostaining. qRT‐PCR revealed was upregulated both mouse models vivo PDGF (platelet‐derived growth factor)–BB‐induced...
Abstract Atherosclerosis is an age‐related pathological process associated with elevated levels of legumain in plaques and plasma. However, the underlying mechanisms remain unclear. The aim this study was to investigate role progression atherosclerotic plaques, a particular focus on functional phenotypic changes CD4 + T cells. Apolipoprotein E‐deficient ( Apoe −/− ) mice were crossed legumain‐deficient Lgmn generate mice. cells accumulated fed high‐fat diet. Deletion attenuated deposition...