A5058799744- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- DNA Repair Mechanisms
- Genetically Modified Organisms Research
- DNA and Nucleic Acid Chemistry
- Toxic Organic Pollutants Impact
- Immune Response and Inflammation
- Cancer therapeutics and mechanisms
- Occupational exposure and asthma
- Radioactive contamination and transfer
- Erythrocyte Function and Pathophysiology
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Viral Infectious Diseases and Gene Expression in Insects
- Immune cells in cancer
- Immunotoxicology and immune responses
- Microtubule and mitosis dynamics
- Hematopoietic Stem Cell Transplantation
- Bioactive Compounds and Antitumor Agents
- Advanced Biosensing Techniques and Applications
- Effects of Radiation Exposure
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Drug Transport and Resistance Mechanisms
Astellas Pharma (Japan)
2006-2018
Kyoto University
1987
Okayama University
1983
At the Washington International Workshop on Genotoxicity Test Procedures (March 25-26, 1999), current methodologies and data for in vitro micronucleus test were reviewed. From this, guidelines conduct of specific aspects protocol developed. Because there are a number important validation studies progress, it was not possible to design definitive, internationally harmonized at this time. Agreement achieved following topics: Cells. The choice cells is flexible, yet cell type should be...
The mouse has traditionally been used for the micronucleus test, with bone marrow usual target organ. aim of 9th collaborative study by CSGMT was to evaluate suitability rat and peripheral blood as Since spleen eliminates circulating micronucleated erythrocytes, a assay might not be feasible. Thirty-four Japanese laboratories six overseas participated in this collaboration, 40 chemicals were studied. As rule, analyzed using acridine orange staining. Among 36 micronucleus-positive...
To examine whether micronucleus tests can be incorporated into general toxicology assays, we performed applying the treatment protocols typically used in such assays. In this 13th Collaborative Study of CSGMT, both rats and mice were tested, although majority studies. Fifteen mutagens tested rats, mainly by oral (p.o.) administration. Micronucleus induction was evaluated 2, 3, 4 days, 1, 28 days after beginning peripheral blood, at bone marrow. Of 15 chemicals that induced micronuclei...
Sensitivity and/or specificity of the in vivo erythrocyte micronucleus (MN) and transgenic rodent mutation (TGR) tests to detect carcinogens non-carcinogens were investigated. The Carcinogenicity Genotoxicity eXperience (CGX) dataset created by Kirkland et al. was used for carcinogenicity vitro genotoxicity data, i.e., Ames chromosome aberration (CA) tests. Broad literature surveys conducted gather MN or TGR test data add CGX dataset. also updated slightly. Data on 379 chemicals (293 86...
Abstract We investigated the performance of an integrated approach to testing and assessment (IATA), designed cover different genotoxic mechanisms causing cancer replicate measured carcinogenicity data included in a new consolidated database. Genotoxic was predicted based on positive results from at least two genotoxicity tests: one vitro vivo (which were associated with mutagenicity categories according Globally Harmonized System classification). Substances belonging double positives...
According to the linear no-threshold model (LNT), even smallest amount of radiation is hazardous. Although LNT not based on solid data, this hypothesis has been applied mutagens and carcinogens. As a result, it postulated that there are no thresholds for these chemicals. To demonstrate negativity by experiments practically impossible, because negative data may leave behind possibility additional might make resolution power high enough change positivity. Furthermore, collection be endless we...
The mouse has traditionally been used for the micronucleus test, with bone marrow usual target organ. aim of 9th collaborative study by CSGMT was to evaluate suitability rat and peripheral blood as Since spleen eliminates circulating micronucleated erythrocytes, a assay might not be feasible. Thirty-four Japanese laboratories six overseas participated in this collaboration, 40 chemicals were studied. As rule, analyzed using acridine orange staining. Among 36 micronucleus-positive...