A5064989830- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Cancer-related Molecular Pathways
- Glaucoma and retinal disorders
- Ocular Disorders and Treatments
- Pain Mechanisms and Treatments
- Hedgehog Signaling Pathway Studies
- Extracellular vesicles in disease
- Cardiac Fibrosis and Remodeling
- Hematopoietic Stem Cell Transplantation
- Medical and Biological Ozone Research
- Virus-based gene therapy research
- Pediatric Pain Management Techniques
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- Laser Applications in Dentistry and Medicine
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Cancer Treatment and Pharmacology
Veneto Eye Bank Foundation
2022-2025
Vita-Salute San Raffaele University
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2024
Maastricht University
2024
University of Turin
2022
Chemotherapy-induced neurotoxicity is an increasingly recognized clinical issue in oncology. vivo confocal microscopy (IVCM) of corneal nerves has been successfully used to diagnose peripheral neuropathies, including diabetic neuropathy. The purpose this study was test if the combination nerve density and morphology assessed by IVCM useful monitor neurotoxic effects chemotherapy compared epidermal quantification. Overall, 95 adult patients with different cancer types were recruited from...
This study aims to assess the efficacy of two aprepitant formulations (X1 and X2), in a preclinical model dry eye disease (DED) induced by benzalkonium chloride (BAK).
Endometrial mesenchymal stromal cells (E-MSCs) extensively contribute to the establishment and progression of endometrial ectopic lesions through formation vascular tissue, support its growth vascularization. As E-MSCs lack oestrogen receptors, endometriosis eradication cannot be achieved by hormone-based pharmacological approaches. Quinagolide is a non-ergot-derived dopamine receptor 2 agonist reported display therapeutic effects in vivo models endometriosis. In present study, we isolated...
Abstract Human epithelial stem cells (ESCs) are characterized by long‐term regenerative properties, much dependent on the tissue of origin and varying during their lifespan. We analysed such variables in cultures ESCs isolated from skin, conjunctiva, limbus oral mucosa healthy donors patients affected ectrodactyly‐ectodermal dysplasia‐clefting syndrome, a rare genetic disorder caused mutations p63 gene. cultured until exhaustion presence or absence DAPT (γ‐secretase inhibitor; N‐[N‐(3,...
The Ectrodactyly-Ectodermal dysplasia-Clefting (EEC) and Ankyloblepharon-ectodermal defect-cleft lip/palate (AEC) syndromes are rare autosomal dominant diseases caused by heterozygous mutations in the p63 gene. Patients characterized abnormalities of skin, teeth, hair have limb defects, orofacial clefting ectodermal dysplasia. In addition, they often show ocular surface alterations, leading to progressive corneal clouding eventually blindness. Here, we present 8 cases describing patients...
<h3>Purpose</h3> The aim of this study was to establish and optimize a new reproducible epithelial wound healing model on human corneas. This assay used the kinetics regeneration following chemical injury. <h3>Methods</h3> Thirty (n=30) corneas unsuitable for transplant were experiments. Corneas cultured in Storagix medium (FBOV) at 31°C. Epithelial integrity before beginning experiments (pre-wound) assessed using vital dyes trypan blue (TB, TB-S 0.25%, AL.CHI.MI.A. srl) sodium fluorescein...