A5105989214- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Cardiovascular Health and Disease Prevention
- Corneal surgery and disorders
- Blood Pressure and Hypertension Studies
- Ophthalmology and Visual Impairment Studies
- Optical Imaging and Spectroscopy Techniques
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal and Macular Surgery
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Neurological Disorders and Treatments
- Renal and Vascular Pathologies
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ocular and Laser Science Research
- Lysosomal Storage Disorders Research
- Non-Invasive Vital Sign Monitoring
- Thermoregulation and physiological responses
FH Aachen
2016-2025
Klinikum rechts der Isar
2006-2022
Technical University of Munich
2005-2022
Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky
2016
RWTH Aachen University
2014
Ludwig-Maximilians-Universität München
2008-2013
Munich University of Applied Sciences
2004-2013
University of Basel
2012
University of Technology
2008-2011
Augenklinik Heidelberg
2007-2008
The present article describes a standard instrument for the continuous online determination of retinal vessel diameters, commercially available analyzer. This report is intended to provide informed guidelines measuring ocular blood flow with this system. principles underlying method and instruments currently available, discusses clinical protocol specific parameters measured by Unresolved questions possible limitations technique are also discussed.
Intravitreal injections are used extensively to treat retinal diseases. Performing an intravitreal injection increases intraocular volume by the amount of fluid brought into eye. Whether this influences pressure (IOP) was investigated here.A biomechanical model relying on 3-dimensional elasticity theory developed determine short-term effect changes IOP. We calculated for 0.1 ml in myopic, emmetropic and hyperopic eyes. Our calculations were compared with IOP measurements obtained immediately...
Abstract Neurovascular coupling can be directly assessed by retinal vessel response to flickering light using optical imaging methods. The is altered in a number of ocular and cardiovascular diseases. Whether it Alzheimer’s disease (AD) investigated. Retinal reaction monochromatic flicker stimulation was examined Dynamic Vessel Analyzer independent the commercial software elderly subjects: 15 patients with mild-to-moderate dementia due AD (ADD); 24 mild cognitive impairment (MCI);...
Rationale : Patients with end-stage renal disease are characterized by increased cardiovascular and all-cause mortality because of advanced remodeling the macrovascular microvascular beds. Objective The aim this study was to determine whether retinal function can predict in patients disease. Methods Results In multicenter prospective observational ISAR (Risk Stratification End-Stage Renal Disease), data on dynamic vessel analysis were available a subcohort 214 dialysis (mean age, 62.6±15.0;...
<h3>Aims</h3> To test the use of parameters obtained from ocular response analyser (ORA) to distinguish between normal and keratoconic eyes, determine severity keratoconus (KC), evaluate changes after treatment with cross-linking (CXL) intrastromal corneal ring (ICR) implantation. <h3>Methods</h3> In total, 42 were derived ORA9s applanation curve. Data on 119 subjects included in study. We determined power discrimination control (n=48) KC patients (stages I II, n=54) using receiver operating...
To investigate changes in the area of foveal avascular zone (FAZ) patients with retinal vascular disease.This retrospective, consecutive study examined 53 eyes macular edema due to branch vein occlusion 25 (47.2%) and nonproliferative diabetic retinopathy 28 (52.8%). The was treated an intravitreal injection 0.05 mL equal 1.25 mg bevacizumab. Before 6-8 weeks after injection, best corrected visual acuity, slit lamp biomicroscopy anterior segment fundus, optical coherence tomography,...
Measurement of pulse wave velocity (PWV) in large vessels has been used extensively clinical practice as an indirect measure arterial stiffness and indicator cardiovascular risk factors. Arterial increases with age coronary artery disease. An vivo method to characterise the central microcirculation was developed.Time-dependent alterations retinal vessel diameter were examined by dynamic analyzer a randomly chosen eye 10 young (26.0 (23.5, 27.0) years old (median (1st quartile, 3rd quartile))...
Abstract Background Cardiac complications driven by microvascular changes are one of the primary reasons for mortality in patients with Fabry disease (FD). While enzyme replacement therapy (ERT) can effectively clear globotriaosylceramide (Gb3) deposits endothelium, it remains controversial whether ERT fully resolves dysfunction, particularly advanced cases. Methods We conducted a cross-sectional observational study 63 FD patients, whom 60 had quality retinal vessel analysis (RVA) data and...
Aims/Purpose: Dynamic Vessel Analysis (DVA) is a non‐invasive imaging modality that evaluates the reactivity of retinal arteriolar and venular vessels in response to flicker light stimulation. This study aims introduce novel data‐processing pipeline involves noise reduction techniques localized different locations along vessel wall. Additionally, it employs standardized parameter extraction, allowing for more precise assessment responses across these locations. Methods: Previous studies used...
Background: The aim of this study was to assess the agreement between different analysis protocols for determination retinal vessel dilation response flicker light (FL) and its relation static metabolic parameters vessels in healthy subjects. Methods: In total, 24 right eyes controls (mean age: 36.04 ± SD 14.4 years) who underwent dynamic diameter oxygen saturation measurements on a Retinal Vessel Analyzer (RVA, Imedos, Jena, Germany) were included. Using repeated video analyses, responses...
Abstract Fabry’s Disease (FD) is one of many disorders that result in altered vascular function. With the Dynamic Vessel Analyzer (DVA, IMEDOS Systems), retinal vessels can be recorded non-invasively real time and dynamic responses to stimuli affect vessel diameter directly visualized. The data obtained further mathematically evaluated terms time- location-dependent behavior. This principle multimodal analysis behavior has been applied demonstrate specific structural functional microvascular...
Abstract Background Inflammation contributes to cardiovascular complications in type 2 diabetes, which are often characterized by microvascular alterations. We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted transmigrating monocytes and granulocytes may represent a biomarker for alterations patients with diabetes nephropathy. Methods MRP8/14 was measured 43 Additionally, the inflammatory markers Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) C-reactive...
Increasing evidence suggests that arterial hypertension (AHT) may begin in childhood and result the premature development of cardiovascular disease. In view this, we believed it would be important to investigate early vascular changes related at micro- macrovascular levels both under normal circumstances after cold-induced sympathetic stimulation.In a cohort 121 adolescent subjects, measured peripheral central blood pressure (pBP cBP, respectively), pulse (PP), augmentation index (AIx), as...
Abstract Objective Hypertension is characterized by microvascular remodeling resulting in increased wall/lumen ratio and elevated stiffness. Aiming to transform the measurement of macrovascular stiffness into a environment we introduce noninvasive method assess rPWV . alterations early hypertension are investigated detail. The developed methodology compared with its possible computational alternatives. Methods Time dependent retinal arterial diameter were assessed noninvasively DVA 65 male...
Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited.All Department Dermatology and Allergology at University Hospital RWTH Aachen Aachen, Germany, who underwent hospitalization a between June 2016 January 2017 (6 months), were followed up until completion wound healing process....
Retinal vessel responses to flickering light are different in various systemic and ocular diseases can be improved after successful therapy. We investigated retinal response age-related macular degeneration (AMD) patients before treatment with a single intravitreal bevacizumab (Avastin(®) ) injection.In 10 exudative AMD [age: median (1.quartile; 3.quartile) 76.0 (73.5; 80.0) years], reactions were examined by Dynamic Vessel Analyser (DVA) 3 months application of (1.25 mg). A baseline...
The ISAR study is a prospective, longitudinal, observational cohort to improve the cardiovascular risk stratification in endstage renal disease (ESRD). major goal characterize phenotype of subjects, namely alterations micro- and macrocirculation determine autonomic function. We intend recruit 500 prevalent dialysis patients 17 centers Munich surrounding area. Baseline examinations include: (1) biochemistry, (2) 24-h Holter Electrocardiography (ECG) recordings, (3) ambulatory blood pressure...
We aimed to characterize several aspects of retinal vascular dynamics in a patient with arrythmia order elicit additional diagnostic information on microvascular dysfunction.