A5034759989- Neuroscience and Neuropharmacology Research
- Glycosylation and Glycoproteins Research
- Retinal Development and Disorders
- Proteoglycans and glycosaminoglycans research
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Ocular Surface and Contact Lens
- Adolescent and Pediatric Healthcare
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Plant Reproductive Biology
- Zebrafish Biomedical Research Applications
- Axon Guidance and Neuronal Signaling
- Photoreceptor and optogenetics research
- Surfactants and Colloidal Systems
- Hearing, Cochlea, Tinnitus, Genetics
- Tryptophan and brain disorders
- EEG and Brain-Computer Interfaces
- Single-cell and spatial transcriptomics
- Reconstructive Facial Surgery Techniques
- Phytoplasmas and Hemiptera pathogens
- Neonatal Respiratory Health Research
- Genetics and Neurodevelopmental Disorders
- Advancements in Transdermal Drug Delivery
- Vascular Malformations and Hemangiomas
Max Planck Institute for Brain Research
2021-2024
Montreal Neurological Institute and Hospital
2014-2023
McGill University
2014-2023
Douglas Mental Health University Institute
2016
Imperial College London
2012
Sofia University "St. Kliment Ohridski"
2009-2011
High-affinity extrasynaptic GABA A receptors are persistently activated by the low ambient levels that known to be present in extracellular space. The resulting tonic conductance generates a form of shunting inhibition is capable altering cellular and network behavior. It has been suggested this will enhanced neurosteroids, antiepileptics, sedative/hypnotic drugs. However, we show ability drugs enhance mouse cerebellum critically depend on levels. For example, intravenous anesthetic propofol...
Escape behavior is a set of locomotor actions that move an animal away from threat. While these can be stereotyped, it advantageous for survival they are flexible.1Evans D.A. Stempel A.V. Vale R. Branco T. Cognitive control escape behaviour.Trends Cogn. Sci. 2019; 23: 334-348Abstract Full Text PDF PubMed Scopus (84) Google Scholar,2Edwards D.H. Heitler W.J. Krasne F.B. Fifty years command neuron: The neurobiology in the crayfish.Trends Neurosci. 1999; 22: 153-161Abstract (260) Scholar,3Peek...
To perform a surface chemistry study of the interactions between benzalkonium chloride (BAC), common preservative used in ophthalmic formulations, and tear film (TF) constituents.The BAC human tears, meibum, rabbit corneal cell lipid extracts at air-water interface were examined vitro during controlled compression-expansion area by Langmuir balance, potential measurements, pendant drop-axisymmetric drop shape analysis (PD-ADSA). Surface pressure-area isotherms isocycles to assess sample's...
The Synapsins (SYN1, SYN2, and SYN3) are important players in the adult brain, given their involvement synaptic transmission plasticity, as well developing brain through roles axon outgrowth synaptogenesis. We others previously reported gene expression dysregulation, both increases decreases, of mood disorders, but little is known about regulatory mechanisms leading to these differences. Thus, we proposed study DNA methylation at theses genes' promoter regions, under assumption that altered...
Abstract The relatively simple and compact morphology of cerebellar granule cells (CGCs) has led to the view that heterogeneity in CGC shape negligible impact upon integration mossy fibre (MF) information. Following electrophysiological recording, 3D models were constructed from high-resolution imaging data identify morphological features could influence coding MF input patterns by adult CGCs. Quantification provided evidence CGCs be connected multiple rosettes arise a single input....
In a small fraction of Xenopus tadpoles, single retinal ganglion cell (RGC) axon misprojects to the ipsilateral optic tectum. Presenting flashes light eye causes that fire, whereas stimulating contralateral excites all other RGC inputs We performed time-lapse imaging individual ipsilaterally projecting axons while either or eye. Stimulating alone reduced elaboration by increasing branch loss. New additions in ipsi were exclusively increased stimulation, which was enhanced expressing tetanus...
During development, patterned neural activity instructs topographic map refinement. Axons with similar patterns of converge onto target neurons and stabilize their synapses these postsynaptic partners, restricting exploratory branch elaboration (Hebbian structural plasticity). On the other hand, non-correlated firing in inputs leads to synapse weakening increased growth axons (Stentian We used visual stimulation control correlation structure a few ipsilaterally projecting (ipsi) retinal...
Abstract Newly synthesized proteins support the development of functional neural circuits and previous work has suggested that dysregulated translation mediates certain forms autism spectrum disorder (ASD). Here, we investigated role Target Rapamycin Complex 1 (TORC1) in synaptic dendritic vivo retinotectal system Xenopus laevis tadpoles. We found TORC1 signaling regulates growth branching acute over‐activation by Rheb overexpression drove enhanced maturation excitatory synapses recruiting...
To avoid predation, animals perform defensive actions that are both instinctive and adaptable to the environment. In mice, decision escape from imminent threats is implemented by a feed-forward circuit in midbrain, where excitatory VGluT2 + neurons dorsal periaqueductal gray (dPAG) compute initiation vigour threat evidence. Here we show GABAergic VGAT dPAG dynamically control this process modulating excitability of neurons. Using vitro patchclamp vivo neural activity recordings freely...
Abstract During development, patterned neural activity instructs topographic map refinement. Axons with similar patterns of activity, converge onto target neurons and stabilize their synapses these postsynaptic partners, restricting exploratory branch elaboration (Hebbian structural plasticity). On the other hand, non-correlated firing in inputs leads to synapse weakening increased growth axons (Stentian We used visual stimulation control correlation structure a few ipsilaterally projecting...
We study the capability of hydrophilic polymers (HPs) to reverse inhibitory effect albumin and restore surface activity lipid-protein lung surfactants preparations (LSPs): Curosurf Survanta. HPs implied are dextran Polyethylene glycol 10000 (PEG10000). LSPs is evaluated in Thin Films (monolayer foam) at air/water interface. Albumin displaces LSP from interface inhibits their ability sustain low tension monolayers form stable thin foam films (FFs). When added they recover maintain dynamic...