A5044501677- Photoreceptor and optogenetics research
- Marine Invertebrate Physiology and Ecology
- Visual perception and processing mechanisms
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Ion channel regulation and function
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Memory and Neural Computing
- Plant and Biological Electrophysiology Studies
- Genetic Neurodegenerative Diseases
- Neural Networks and Applications
- Cognitive Science and Education Research
- Neurogenetic and Muscular Disorders Research
- Cephalopods and Marine Biology
- Neuroscience, Education and Cognitive Function
- Visual Attention and Saliency Detection
- Muscle Physiology and Disorders
- Color perception and design
- Spectroscopy and Chemometric Analyses
- Spatial Cognition and Navigation
- Augustinian Studies and Theology
- EEG and Brain-Computer Interfaces
- Genetics, Bioinformatics, and Biomedical Research
National Research Council
1995-2024
Fondazione Bruno Kessler
2013-2024
University of Trento
2016-2019
Instituto di Biofisica
2013-2018
Institute of Biophysics
2017
Istituto di Cibernetica “Eduardo Caianiello”
1995-2008
University of Pisa
1986-1995
Abstract Opsins play a key role in the ability to sense light both image-forming vision and non-visual photoreception (NVP). These modalities, most animal phyla, share photoreceptor protein: an opsin-based protein binding light-sensitive chromophore by lysine (Lys) residue. So far, visual opsins have been discovered throughout Metazoa including photoresponsive Hydra , eyeless cnidarian considered evolutionary sister species bilaterians. To verify whether influences modulates opsin gene...
Alzheimer's disease (AD) is the most common cause of dementia. At pre-symptomatic phase disease, processing amyloid precursor protein (APP) produces toxic peptides, called amyloid-β 1–42 (Aβ 1–42). The downstream effects Aβ production are not completely uncovered. Here, we report involvement transglutaminase 1 (TG1) in vitro AD models neuronal toxicity. TG1 was increased at late stages hippocampus a mouse model and primary cortical neurons undergoing stress. Silencing TGM1 gene sufficient to...
Methods for the conversion of human induced pluripotent stem cells (hiPSCs) into motor neurons (MNs) have opened to generation patient-derived in vitro systems that can be exploited MN disease modelling. However, lack simplified and consistent protocols fact hiPSC-derived MNs are often functionally immature yet limit opportunity fully take advantage this technology, especially research aimed at revealing phenotypes manifested mature cells. In study, we present a robust, optimized monolayer...
A living bio-hybrid system has been successfully implemented. It is constituted by neuroblastic cells, the SH-SY5Y human neuroblastoma adhering to a poly-anyline (PANI) semiconductor polymer with memristive properties. By multidisciplinary approach, biocompatibility of substrate analyzed and functionality cells investigated. We found that PANI films can support cell adhesion. Moreover, were differentiated into neuron-like for in vitro applications demonstrating also promote differentiation....
The study of neurons is fundamental to unraveling the complexities nervous system. Primary neuronal cultures from rodents have long been a cornerstone experimental studies, yet limitations related their non-human nature and ethical concerns prompted development alternatives. In recent years, derivation human-induced pluripotent stem cells (hiPSCs) has emerged as powerful option, offering scalable source for diverse applications. Neural progenitor (NPCs) derived hiPSCs can be efficiently...