A5006595070- Tuberculosis Research and Epidemiology
- Inhalation and Respiratory Drug Delivery
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Drug Delivery Systems
- Computational Drug Discovery Methods
- Bacteriophages and microbial interactions
- Pancreatic and Hepatic Oncology Research
- Extracellular vesicles in disease
- Asthma and respiratory diseases
- Respiratory viral infections research
- Monoclonal and Polyclonal Antibodies Research
- Milk Quality and Mastitis in Dairy Cows
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Piperaceae Chemical and Biological Studies
- Clostridium difficile and Clostridium perfringens research
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Immune cells in cancer
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Genetic and Kidney Cyst Diseases
- Body Contouring and Surgery
National JALMA Institute for Leprosy & Other Mycobacterial Diseases
2018-2025
Academy of Scientific and Innovative Research
2024-2025
National Dairy Research Institute
2025
Krishi Vigyan Kendra, Ghatkhed Amravati
2025
Tumkur University
2024
Tribhuvan University
2024
Army Hospital Research and Referral
2016-2022
Indian Council of Agricultural Research
2022
Indian Council of Medical Research
2022
Central Drug Research Institute
2008-2021
Inhalable clofazimine-containing dry powder microparticles (CFM-DPI) and native clofazimine (CFM) were evaluated for activity against Mycobacterium tuberculosis in human monocyte-derived macrophage cultures mice infected with a low-dose aerosol. Both formulations resulted 99% killing at 2.5 μg/ml vitro. In mice, 480 μg 720 CFM-DPI inhaled twice per week over 4 weeks reduced numbers of CFU the lung by as much log(10) 2.6; 500 oral CFM achieved 0.7 reduction.
Enhanced treatment for CNS-TB: Intranasal chitosan nano-aggregates with Anti-TB drugs overcome the blood–brain barrier and reduce mycobacterial load.
Growing rates of tuberculosis (TB) superbugs are alarming, which has hampered the progress made to-date to control this infectious disease, and new drug candidates few. Epigallocatechin gallate (EGCG), a major polyphenolic compound from green tea extract, shows powerful efficacy against TB bacteria in vitro studies. However, therapeutic molecule is limited due poor pharmacokinetics low bioavailability following oral administration. Aiming improve treatment outcomes EGCG therapy, we...
Tuberculosis (TB) triggers a robust immune response, which leads to significant destruction of the lung tissue at site infection, aiding in transmission Mycobacterium tuberculosis (Mtb) hosts. The excessive inflammatory response contributes heavily extracellular matrix (ECM) damage, is linked high mortality rates among TB patients. Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, are pivotal breakdown ECM, worsening destruction. In context host-directed therapy (HDT), strategy...
The study was conducted to evaluate the effect of phytoadditive mixtures containing equal proportions Curcuma longa & Allium sativum (PAM-1) and Ocimum sanctum (PAM-2) on live weight, blood parameters, hormonal profile reproductive performance in Black Bengal goats. A total 21 post weaned female kids 3–4 months age similar body weights maintained at Goat Research Unit Eastern Regional Station (ERS), National Dairy Institute (NDRI), Kalyani, India during year 2021–2022 were randomly...
Mycobacterium tuberculosis (Mtb) demonstrates a proclivity for infecting extrapulmonary sites, notably the brain. Treating these (TB) manifestations is challenging due to difficulty of drug delivery across blood-brain barrier. Clofazimine (CLF) has exhibited promising activity against Mtb, including multidrug-resistant variants, in vitro and preclinical animal models. However, its clinical implication restricted owing poor physicochemical pharmacokinetic properties. This study aims develop...
Although nitric oxide (NO) is a bactericidal component of the macrophage's innate response to intracellular infections such as tuberculosis (TB), prolonged inhalation NO gas has little benefit in chemotherapy TB. The impact controlled release through delivery donors macrophages infected vitro with Mycobacterium (Mtb) was investigated. Inhalable microparticles (MP) were prepared by spray-drying. Isosorbide mononitrate (ISMN), sodium nitroprusside (SNP), and diethylenetriamine adduct (DETA/NO)...
The majority of preclinical research has shown that Mycobacterium tuberculosis can modify host lipids in various ways. To boost its intramacrophage survival, M. causes to build up, resulting the development lipid-laden foam cells. binds and enters macrophage via cell membrane cholesterol. Aggregation cholesterol wall an increase vascularity at granuloma site reduce permeability rifampicin isoniazid concentrations. However, very few studies have assessed effect statins on drug penetration....
To combat the rapidly emerging drug-resistant M. tuberculosis, it is now essential to look for alternative therapeutics. Mycobacteriophages can be considered as efficient therapeutics due their natural ability infect and kill mycobacteria including tuberculosis. Here, we have exploited mycolyl-arabinogalactan esterase property of LysB encoded from mycobacteriophage D29. This study novel in terms targeting a multi-drug-resistant pathogenic strain tuberculosis with also examining combination...
Myroides spp., previously known as Flavobacterium odoratum, are rare clinical isolates and often considered non-pathogenic. Natural habitat includes soil, fresh marine waters, in foods sewage treatment plants. We present an unusual case of fatal pericardial effusion due to odoratus a patient suffering from chronic kidney disease undergoing maintenance haemodialysis. This is presented show the increasing incidence causing localized systemic infections their high intrinsic resistance many...
Mycobacterium tuberculosis, which causes is one of the leading infectious agents worldwide with a high rate mortality. Following aerosol inhalation, M. tuberculosis primarily infects alveolar macrophages, results in host immune response that gradually activates various antimicrobial mechanisms, including production reactive oxygen species (ROS), within phagocytes to neutralize bacteria. OxyR master regulator oxidative stress several bacterial species. However, due absence functional oxyR...
Context Mastitis is an inflammation of mammary gland parenchyma, and unending cause economic loss to the dairy industry. The interest in research on biomarker discovery for diagnosis bovine mastitis stems largely from need identify reliable biomarkers. Aim To determine putative biomarkers by using bioinformatics analysis, experimental validation pro-inflammatory cytokines oxidative stress healthy diseased animals. Methods Various silico analysis tools were applied screen gene expression...