A5032554144- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Endoplasmic Reticulum Stress and Disease
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Acute Kidney Injury Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Advanced Glycation End Products research
- Autophagy in Disease and Therapy
- Chronic Kidney Disease and Diabetes
- Lymphoma Diagnosis and Treatment
- Hereditary Neurological Disorders
- Inflammation biomarkers and pathways
- CAR-T cell therapy research
Friedrich Schiller University Jena
2019-2024
Abstract Overexpression of MYC is a genuine cancer driver in lymphomas and related to poor prognosis. However, therapeutic targeting the transcription factor remains challenging. Here, we show that inhibition histone deacetylase 6 (HDAC6) using HDAC6 inhibitor Marbostat-100 (M-100) reduces oncogenic levels prevents lymphomagenesis mouse model -induced aggressive B-cell lymphoma. M-100 specifically alters protein-protein interactions by switching acetylation state substrates, such as tubulin....
Advanced glycation end products (AGEs) are a heterogeneous group of molecules with potential pathophysiological effects on the kidneys. Fibrosis together accumulation AGEs has been investigated for its contribution to age-related decline in renal function. mediate their large parts through interactions receptor (RAGE). RAGE is transmembrane protein that belongs immunoglobulin superfamily and ability interact multiple pro-inflammatory/pro-oxidative ligands. The role aging kidneys not fully...
Aging of the immune system is described as a progressive loss ability to respond immunologic stimuli and commonly referred immunosenescence. B cell immunosenescence characterized by decreased differentiation rate in bone marrow accumulation antigen-experienced age-associated cells secondary lymphoid organs (SLOs). A specific deletion POZ-domain transcription factor Miz-1 pro-B cells, which known be involved hematopoiesis, leads premature aging lineage. In mice, this causes severe reduction...
Sepsis is a life-threatening condition caused by dysregulated host responses to infection. Myeloid cell accumulation and lymphocyte decline are widely recognized phenomena in septic patients. However, the fate of specific immune cells remains unclear. Here, we report results human explorative study patients with peritonitis undergoing abdominal surgery without sepsis. We analyzed pairwise peritoneal fluid peripheral blood taken 24 h after characterize immediate changes. Our show that myeloid...
Abstract Overexpression of MYC is a genuine cancer driver in lymphomas and related to poor prognosis. However, therapeutic targeting the transcription factor remains challenging. Here, we show that inhibition histone deacetylase 6 (HDAC6) using HDAC6 inhibitor Marbostat-100 (M-100) reduces oncogenic levels prevents lymphomagenesis mouse model -induced aggressive B-cell lymphoma. M-100 specifically alters protein-protein interactions by switching acetylation state substrates, such as tubulin....