A5014597670- Hepatitis B Virus Studies
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
Desmond Tutu HIV Foundation
2014
Stellenbosch University
2014
<h3>Background</h3> Early initiation of antiretroviral therapy (ART) in HIV-infected infants reduces mortality and opportunistic infections including tuberculosis (TB). However, young children remain at high risk TB disease following mycobacterial infection. We document the spectrum <2 years age on ART. <h3>Methods</h3> Retrospective cohort study; records initiating routine ART Tygerberg Children9s Hospital, Cape Town, January 2003–December 2010 were reviewed. Clinical data (baseline)...
Hepatocellular injury has been reported commonly in adults on rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) treatment. However, there are limited data children.Two pharmacokinetic studies of children (0-17 years) routinely treated for RR/MDR-TB were conducted Cape Town, South Africa between October 2011 February 2020. adverse events (AEs; defined as elevated alanine aminotransferase [ALT]) documented serially. Data analyzed to determine the incidence, etiology, risk...