A5076119993- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Caveolin-1 and cellular processes
- Nanoparticle-Based Drug Delivery
- Asthma and respiratory diseases
- Genomics, phytochemicals, and oxidative stress
- FOXO transcription factor regulation
- Mitochondrial Function and Pathology
- Nanoparticles: synthesis and applications
- Receptor Mechanisms and Signaling
- Fibroblast Growth Factor Research
- Genetic Mapping and Diversity in Plants and Animals
- Systemic Sclerosis and Related Diseases
- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Estrogen and related hormone effects
- Dermatology and Skin Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Energy and Environment Impacts
Max Planck Institute for Heart and Lung Research
2017-2025
Iran's National Elites Foundation
2024
Iran Khodro (Iran)
2024
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2022
Instituto de Salud del Estado de México
2022
German Center for Lung Research
2017
Max Planck Society
2017
Justus-Liebig-Universität Gießen
2012
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal parenchymal lung disease with limited therapeutic options, fibroblast-to-myofibroblast transdifferentiation hyperproliferation playing major role. Investigating
Biomarkers of atopic dermatitis (AD) are largely lacking, especially in infant AD. Those that have been examined to date focused mostly on serum cytokines, with few noninvasive biomarkers the skin.We aimed explore obtainable from sampling skin. We compared these plasma and structural functional measures skin barrier.We recruited 100 infants at first presentation AD, who were treatment naive topical or systemic anti-inflammatory therapies, 20 healthy children. sampled clinically unaffected by...
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease with unknown etiology poor prognosis. IPF patients die within 2 years after diagnosis mostly due to respiratory failure. Current treatments against aim ameliorate patient symptoms delay progression. Unfortunately, therapies targeting the causes of or reverting have not yet been developed. Here we show that reduced levels miRNA 7d ( MIRLET7D ) in compromise epigenetic gene silencing mediated...
Background: Small cell lung cancer (SCLC) is an extremely aggressive type with a patient median survival of 6-12 months.Epidermal growth factor (EGF) signaling plays important role in triggering SCLC.In addition, factor-dependent signals and alpha-, beta-integrin (ITGA, ITGB) heterodimer receptors functionally cooperate integrate their pathways.However, the precise integrins EGF receptor (EGFR) activation SCLC remains elusive.Methods: We analyzed human precision-cut slices (hPCLS),...
As a pathologically heterogeneous disease, cancer is one of the leading causes global morbidity. According to World Health Organization, approximately in six deaths are caused by cancer. Fortunately, many cancers can be cured if diagnosed at early stages and treated efficiently. Despite benefits conventional treatments such as surgery, chemotherapy, hormone therapy, radiation they have several drawbacks, including cytotoxicity, inaccurate targeting tumor cells, multi-drug resistance, which...
We performed an integrative transcriptomic in silico analysis using lung adenocarcinoma A549 cells treated with the neddylation inhibitor MLN4924 and gefitinib-resistant PC9 cell line (PC9GR). focused on transcriptional effects of top differentially expressed ncRNA biotypes their correlating stemness factors. Interestingly, MLN4924-treated showed a significant upregulation mRNAs involved carcinogenesis, attachment, differentiation pathways, as well parallel downregulation maintenance...
Mitochondria are ATP-producing organelles in eukaryotic organisms that serve as the cell’s power plants. Besides, mitochondria integral to regulating cellular homeostasis and metabolism a result of their essential roles reactive oxygen species (ROS) production, bioenergetics, catabolism anabolism, heme iron-sulfur biosynthesis, iron calcium homeostasis, apoptosis signal transduction, well immunity inflammation. It is accepted evolutionarily derived from endosymbiotic...
Gene expression regulation is one of the most fundamental cellular processes, enabling activation a gene to produce either translatable protein-coding transcript (mRNA) or functional non-coding RNA with regulatory functions, ultimately determining cell identity and function. Although can occur at transcriptional, translational, post-translational levels, transcription initiation first important step in expression, facilitating transfer biological information from DNA protein. Enhancers...
Non-coding RNAs (ncRNAs) are important regulators of different biological processes in the nucleus cell as part machinery controlling chromatin structure at specific loci. However, full extent function ncRNAs has remained elusive, since involvement nuclear microRNAs (miRNAs) not been investigated. Here we deciphered a miRNA during transcriptional regulation. We show that mature directly binds to and RNA exosome complex induce heterochromatin through histone methyl transferases, SUV39H1 EZH2,...
Abstract Small cell lung cancer (SCLC) is an extremely aggressive type with a patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays important role in triggering SCLC. In addition, factor-dependent signals and alpha-, beta-integrin (ITGA, ITGB) heterodimer receptors functionally cooperate integrate their pathways. However, the precise integrins EGF receptor (EGFR) activation SCLC has remained elusive. We analyzed RNA-sequencing data, human precision-cut slices...