A5037402171- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Healthcare Systems and Reforms
- Healthcare Policy and Management
- Osteoarthritis Treatment and Mechanisms
- Global Maternal and Child Health
- Inflammatory mediators and NSAID effects
- Pain Mechanisms and Treatments
- Tuberculosis Research and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Knee injuries and reconstruction techniques
- Global Public Health Policies and Epidemiology
- Healthcare cost, quality, practices
- Global Health Care Issues
- Chemokine receptors and signaling
- HIV/AIDS Impact and Responses
- Healthcare Systems and Challenges
- Child and Adolescent Psychosocial and Emotional Development
- Global Cancer Incidence and Screening
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- HIV, Drug Use, Sexual Risk
- Vaccine Coverage and Hesitancy
- Resilience and Mental Health
- Suicide and Self-Harm Studies
University of Oxford
2024-2025
University of Antwerp
2020-2024
South African Medical Research Council
2024
Muhimbili University of Health and Allied Sciences
2021
London School of Hygiene & Tropical Medicine
2021
Ifakara Health Institute
2021
Center for Global Development
2021
Relief International
2021
Karolinska Institutet
2020-2021
Philadelphia University
2019-2021
Abstract We investigated the expression and functions of chemokine receptors in neural progenitor cells isolated from embryonic adult mice. Reverse transcriptase‐polymerase chain reaction (RT‐PCR) analysis demonstrated mRNA for most known grown as neurospheres (E17) (4‐week‐old) The CXCR4 was further E17 using immunohistochemistry, situ hybridization, Northern blot fura‐2‐based Ca 2+ imaging. Most mice responded to stromal cell‐derived factor‐1 (SDF‐1/CXCL12) imaging studies. In addition,...
Pain is the predominant symptom of osteoarthritis, but connection between joint damage and genesis pain not well understood. Loss articular cartilage a hallmark it occurs through enzymatic degradation aggrecan by cleavage mediated disintegrin metalloproteinase with thrombospondin motif 4 (ADAMTS-4) or ADAMTS-5 in interglobular domain (E373–374A). Further MMPs (N341–342F) releases 32-amino-acid fragment (32-mer). We investigated role this 32-mer driving pain. found that excites dorsal root...
Blood vessel loss and inflammation cause secondary degeneration following spinal cord injury. Angiopoietin-1 through the Tie2 receptor, other ligands αvβ3 integrin, promote endothelial cell survival during developmental or tumour angiogenesis. Here, daily intravenous injections with an αvβ3-binding peptide named C16 angiopoietin-1 mimetic a contusion at thoracic level 9 in mice rescued epicentre blood vessels, white matter locomotor function, reduced detrimental inflammation. Preserved...
► The COVID-19 poverty trap is shaped by barriers to accessing prevention, vulnerability economic disruption and financial uncertainties, incurrence of catastrophic costs as people try cope with the outbreak.► To ensure socioeconomic stability confidence during public health crises in long run, social protection schemes (e.g.social insurance, microfinancing) must be place help loss income security reduced society.
Background In Vietnam, PrEP was introduced in 2017 and scaled up from 2019. Private sector engagement (PSE) service delivery deployed as a strategy the start to increase access. We assessed effectiveness of this approach inform ongoing efforts accelerate epidemic control by 2030. Methods implemented process evaluation with longitudinal design using retrospective programmatic data collected uploaded onto secure online system (HMED) 23 public 17 private clinics Hanoi, Ho Chi Minh City (HCMC),...
We investigated the expression and role of dopamine receptor 3 (D3R) in postnatal mouse subventricular zone (SVZ). In situ hybridization detected selective D3R mRNA SVZ. Fluorescence activated cell sorting (FACS) adult SVZ subtypes using hGFAP-GFP Dcx-GFP mice showed that transit amplifying progenitor cells niche astrocytes expressed whereas stem cell-like neuroblasts did not. To determine D3R's neurogenesis, we administered U-99194A, a preferential antagonist, bromodeoxyuridine mice. vivo...
Stigma regarding viral hepatitis and liver disease has psychological social consequences including causing negative self-image, disrupting relationships, providing a barrier to prevention, testing, treatment. The aim of this study was characterize compare HBV knowledge stigma in Vietnamese Ho Chi Minh City Chicago begin evaluate the cultural context stigma. Methods . A written survey questions validated questionnaire distributed Chicago. 842 surveys from 170 were analyzed. Results living had...
Background : Health risk behavior among young people is a public health problem in Vietnam. In addition, road traffic injuries are the leading cause of death for those aged 15–29 years. The consequences can be devastating adolescents and their families, create significant economic burden on society. Objective aim this study was to identify protective factors that may influence three behaviors school children: suicidal thinking (ST), drinking alcohol (DA), underage motorbike driving (MD)....
J. Neurochem. (2011) 10.1111/j.1471‐4159.2011.07509.x Abstract The chemokine BRAK/CXCL14 is an ancient member of the family whose functions in brain are completely unknown. We examined distribution CXCL14 nervous system during development and adult. Generally speaking, was not expressed prior to birth, but it developing whisker follicles (E14.5) subsequently hair skin. Postnatally, also highly many regions brain, including cortex, basal ganglia, septum hippocampus. dorsal root ganglia....
People living with multimorbidity (PLWMM) have multiple needs and require long-term personalised care, which necessitates an integrated people-centred approach to healthcare. However, care may risk being a buzzword in global health cannot be achieved unless we consider prioritise the lived experience of people themselves. This study captures experiences PLWMM low- middle-income countries (LMICs) by exploring their perspectives, experiences, aspirations. We analysed 50 semi-structured...
In England, and many other countries, immunity to SARS-CoV-2 infection COVID-19 disease is highly heterogeneous. Immunity has been acquired through natural infection, primary booster vaccination, while protection lost waning viral mutation. During the height of pandemic in main aim was rapidly protect population large supplies vaccine were pre-purchased, eliminating need for cost-effective calculations. As we move an era where majority infections cause relatively mild disease, stocks be...
A costly modern-day double burden, the expenses of noncommunicable diseases (NCDs) are becoming a devastating epidemic. The World Health Organization estimates $7 trillion in economic losses from NCDs 2011-2025. Although regarded as affluent diseases, burden is shifting into poorer groups. In this study, we assessed socioeconomic inequalities catastrophic health expenditure and impoverishment associated with Northern Vietnam. We also identified factors for impoverishment. Households...
Background The World Health Organization (WHO) stresses the importance of active case-finding (ACF) for early detection tuberculosis (TB), especially in 30 high-burden countries that account almost 90% cases globally. Objective To describe attitudes National TB Programme (NTP) managers related to ACF policy development, implementation and scale-up countries, review national strategic plans. Methods This was a mixed-methods study with an embedded design: A cross-sectional survey NTP yielded...
Vietnam has a high burden of undetected tuberculosis (TB). The Vietnamese National TB Strategic Plan highlights active case-finding (ACF) as one strategy to find people with who are currently unreached by the existing government health services. IMPACT (Implementing proven community-based intervention) project was implemented across six districts Ho Chi Minh City, 2017-2019. We aimed explore facilitators and barriers for ACF implementation during understand how why intervention achieved yields.
The primary health care system in Vietnam has been playing an important role prevention and control of diseases. This study aimed to describe the capacity commune stations Chi Linh district, Hai Duong province for noncommunicable diseases (NCDs). A mixed-methods (quantitative qualitative approaches) approach was applied collect data 20 stations. participants, including workers, stakeholders, patients with NCDs, were selected study. findings reported that main activities NCDs at (CHSs) still...