Abstract Background Current DHHS guidelines recommend starting ART in PWH immediately or as soon possible after HIV diagnosis to improve uptake, linkages care and virologic suppression (VS). But there is little data measuring the longitudinal impact of rapidly ART. We previously showed that significantly decreased time VS. This study compares effects rapid start versus delayed initiation on retention VS a defined cohort PWH. Methods IRB-approved follow up single-center, retrospective cohort....

Abstract In a single-center retrospective follow-up study, no difference in retention care or virologic suppression was noted between rapid and delayed initiation of antiretroviral therapy at 6-year follow up participants who were naive. Further study is needed to assess the long-term impact rapidly starting therapy.

Abstract This retrospective chart review evaluated changes in serum creatinine and clearance (CrCl) after initiation of an integrase inhibitor (INSTI)-based regimen as initial treatment human immunodeficiency virus-infected adults. Serum CrCl were similar to those seen clinical trials for INSTIs. No renal-related serious adverse events or discontinuations occurred.

Objective: To describe a case of Cushing syndrome in child during concurrent use inhaled fluticasone propionate, nasal mometasone, and highly active antiretroviral regimen including lopinavir/ritonavir. Case Summary: A 9-year-old boy with HIV infection asthma developed moon fades, increased facial hair, weight after propionate inhalation (1 puff; 220 μg) therapy was begun. His antiretroviraI contained the protease inhibitor combination lopinavir/ritonavir at dose 216/54 mg twice daily, he...

Journal Article Alternative antiretroviral therapy formulations for patients unable to swallow solid oral dosage forms Get access Joan M. Duggan, M.D., FACP, FIDSA, AAHIVS, AAHIVS Infectious Diseases Specialis Division of Diseases, Department Medicine, University Toledo Medical Center (UTMC),Toledo, OH Search other works by this author on: Oxford Academic Google Scholar Barbara Akpanudo, M.S.N., M.P.H., CNP, CNP Family Nurse Practitioner Vipul Shukla, B.S., B.S. medical student Glen...

There are no data regarding the activity of clarithromycin's active metabolite, 14-hydroxy clarithromycin, against penicillin-intermediate, penicillin-resistant or erythromycin-resistant Streptococcus pneumoniae. Agar dilution MICs were determined for clarithromycin (henceforth called ‘metabolite’), azithromycin, erythromycin and clarithromycin/metabolite (2:1 1:1 ratio) 24 penicillin-intermediate 14 strains, including 13 clinical strains one ATCC strain S. The interaction between its...

Pharmacokinetic studies have shown that the concomitant use of atazanavir and proton pump inhibitors (PPIs) decreases plasma concentrations. Data describing clinical outcomes associated with this drug interaction are limited.To describe outcomes, in terms viral load (VL) suppression, concurrent ritonavir-boosted or unboosted PPIs.A retrospective chart review 301 HIV-positive adults attending an Ohio infectious diseases clinic was performed to identify patients prescribed atazanavir, without...

Long-acting cabotegravir (CAB-LA) provides an exciting new option for pre-exposure prophylaxis (PrEP) in multiple populations. In this Perspective, we consider the unique pharmacokinetics of CAB-LA and potential impact on prescribing CAB-LA, specifically cis-women reproductive potential.

The level of patient-pharmacist interactions and services provided varies across different distribution methods could affect patient satisfaction with services. Determining these medication is important for improving care chronic disease patients. This study evaluated the validity reliability a modified survey to assess mail-order community pharmacy settings. Exploratory cross-sectional design using convenience sample HIV-infected patients at university clinic was used. Satisfaction scale...

Objective: To report the case of a 46-year-old woman with HIV infection who developed gingival hypertrophy while taking amlodipine for hypertension and review literature discussing associated other calcium channel blockers. Case Summary: A HIV-infected female was 5 mg daily to manage hypertension. After 4 1/2 years exposure amlodipine, patient presented new-onset hypertrophy. Concurrent medications included atazanavir, ritonavir, tenofovir/emtricitabine, multivitamin, ibuprofen tramadol as...

Translation: The University of Toledo Journal Medical Sciences is the online journal launched by Toledo. Manuscripts will be considered on understanding that they report original work and are not under consideration for publication any other journal. publishes articles reporting experimental results basic or clinical research, case reports, reviews. uses a single blind peer review system each manuscript, based presented in its submission, evaluated two student reviewers one faculty reviewer....

Abstract Using multiple pharmacies has been linked to negative outcomes including increased inappropriate drug use, toxicity, and mortality, yet up half of all patients in the US use pharmacies. A pilot survey was administered measure pharmacy people living with HIV (PWH) examine associated attitudes outcomes. In a midwestern clinic, convenience sample surveyed based on using single (SPU) versus (MPU). One hundred forty-two subjects participated (69 SPU; 73 MPU): 75% male, 59% white, >...

Abstract Timely initiation of antiretroviral therapy (ART) for non-occupational post-exposure prophylaxis (nPEP) is crucial in preventing HIV infection and advancing efforts to end the epidemic (EHE). nPEP must be administered within 72 h high-risk exposure, ideally 24 h. Pharmacies may play a role increasing access facilitating referrals additional care, such as PrEP. Recent legislation permits pharmacist-prescribed (PDP), though provider attitudes toward this change have not been studied....

Background: Limited data exist on the use of a boosted protease inhibitor plus <2 active nucleoside/nucleotide reverse transcriptase inhibitors without additional classes antiretroviral (ARV) therapy in treatment-experienced patients with background resistance. Objective: To evaluate clinical outcomes HIV-infected harboring single- or multiclass resistant virus and receiving once-daily tenofovir/emtricitabine (TDF/FTC) darunavir/ritonavir (DRV/r) administered for >24 weeks. Methods:...

Abstract Purpose Data support the individual and public health advantages of shortened time intervals between HIV diagnosis, initiation antiretroviral therapy (ART), virologic suppression. The from diagnosis to linkage care, ART, suppression was evaluated in newly diagnosed, ART-naive individuals after structured programmatic changes were implemented reduce (TVS). Methods retrospective cohort included adult patients receiving care a Midwestern Ryan White Clinic. Study periods January 1,...

Objectives:(1) To estimate the total costs of hepatitis C treatment choices recommended by Saudi Association for Study Liver Diseases and Transplantation (SASLT) based on data from Food Drug Authority (SFDA), (2) develop operationalize decision tree model calculate base case incremental cost-effectiveness ratio (ICER), (3) perform oneway probabilistic sensitivity analyses testing underlying assumptions in model.Methods: A analysis was performed a hypothetical cohort comparing different...