A5026489595- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Toxin Mechanisms and Immunotoxins
- Virus-based gene therapy research
- RNA regulation and disease
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Vestibular and auditory disorders
- Animal Virus Infections Studies
- Nail Diseases and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Aquaculture disease management and microbiota
- Insect and Pesticide Research
- Pain Mechanisms and Treatments
- Bee Products Chemical Analysis
- Viral Infections and Immunology Research
- Biosensors and Analytical Detection
- Parvovirus B19 Infection Studies
- Antimicrobial Resistance in Staphylococcus
- Phenothiazines and Benzothiazines Synthesis and Activities
- Viral gastroenteritis research and epidemiology
- Contact Dermatitis and Allergies
- Antimicrobial Peptides and Activities
Kyoto Research Park
2020
Maruho (Japan)
2019-2020
National Institute of Infectious Diseases
2006-2012
University of California, San Francisco
2009-2010
National Institutes of Health
2008-2009
Nagoya University
2002-2007
Japan Science and Technology Agency
2004-2005
Mie University
2000-2002
Sensorineural hearing loss (SNHL) is the most common congenital disease. Longitudinal studies of infants with cytomegalovirus (CMV) infection have demonstrated an association between CMV and SNHL. However, because lack suitable neonatally collected specimens, proportion CMV-associated SNHL has not been defined, nor relationship major genetic causes SNHL, such as mutations in GJB2 gene.Sixty-seven children severe were analyzed for human herpesvirus 6 (HHV-6) infections mutations. DNA...
The UL51 gene of herpes simplex virus type 1 (HSV-1) encodes a phosphoprotein whose homologs are conserved throughout the family. Recently, we reported that protein colocalizes with Golgi marker proteins in transfected cells and targeting to apparatus depends on palmitoylation its N-terminal cysteine at position 9 (N. Nozawa, T. Daikoku, Koshizuka, Y. Yamauchi, Yoshikawa, Nishiyama, J. Virol. 77:3204-3216, 2003). However, role HSV replication cycle was unknown. Here, generated UL51-null...
ABSTRACT The UL56 gene product of herpes simplex virus (HSV) has been shown to play an important role in viral pathogenicity. However, the properties and functions protein are little understood. We raised rabbit polyclonal antisera specific for HSV type 2 (HSV-2) examined its expression properties. was identified as three polypeptides with apparent molecular masses ranging from 32 35 kDa HSV-2-infected cells, at least one species phosphorylated. Studies their origins showed that HSV-2 is...
The herpes simplex virus type 1 (HSV-1) UL51 gene products are virion-associated phosphoproteins with apparent molecular masses of 27, 29, and 30 kDa in HSV-1-infected cells. In this study, we have investigated the intracellular localization distribution protein both infected cells transfected expressing only UL51. We found that colocalized closely Golgi marker proteins such as Golgi-58K GM130 However, cells, localized to juxtanuclear region but partially maker proteins. Mutant analysis...
We investigated human cytomegalovirus pathogenesis by comparing infection with the low-passage, endotheliotropic strain VR1814 and attenuated laboratory AD169 in placental villi as explants vitro xenografts transplanted into kidney capsules of SCID mice (ie, severe combined immunodeficiency). In this vivo placentation model, cytotrophoblasts invade renal parenchyma, remodel resident arteries, induce a robust lymphangiogenic response. replicated villous cell column reduced formation anchoring...
Since congenital cytomegalovirus (CMV) infection causes late-onset sequelae, the identification of CMV-infected newborns is important. For this purpose, we established a simple real-time PCR assay using filter disk. Combined with collection urine papers placed in diaper, can make CMV screening more feasible and cost-effective.
Abstract The in vitro microbicidal activity of benzoyl peroxide against Cutibacterium acnes , Staphylococcus aureus epidermidis Escherichia coli Pseudomonas aeruginosa Candida albicans Malassezia furfur restricta, and globosa was investigated. These strains were incubated for 1 h the presence 0.25, 0.5, 1, or 2 mmol/L phosphate buffered saline supplemented with 0.1% glycerol 2% Tween 80. After exposure to peroxide, counts viable Gram‐positive bacteria fungi markedly decreased, whereas...
To simplify the titration of infectious varicella-zoster virus (VZV), we generated a reporter cell line that produced luciferase in dose-dependent manner upon infection with cell-free VZV. A few VZV-infected cells were detectable by coculturing line. We demonstrated usefulness for antiviral studies.
DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 43:15-26 (2000) - doi:10.3354/dao043015 Clinical trial results on use a recombinant feline interferon-ω protect Japanese pearl oysters Pinctada fucata martensii from akoya- virus infection Teruo Miyazaki*, Naoki Nozawa, Tatsuya Kobayashi Faculty Bioresources, Mie University, 1515 Kamihama, Tsu, Mie, Japan *E-mail:...
BackgroundAmenamevir (AMNV) is a helicase-primase inhibitor with antiviral activity against herpesviruses [herpes simplex viruses (HSV)-1 and -2, varicella-zoster virus], which are associated the development of acute herpetic pain (AHP) postherpetic neuralgia. However, inhibitory effects inhibitors on AHP neuralgia remain incompletely understood.ObjectiveIn this study, we investigated AMNV (PHP) in HSV-1-infected mice accompanied by zosteriform-like skin lesions.MethodsHSV-1 was...
In a previous study we determined that administration of recombinant feline interferon-omega (rFeIFN-omega) could protect Japanese pearl oysters Pinctada fucata martensii from akoya-virus infection. Our results suggested rFeIFN-omega enhanced the potential agranulocytes to phagocytize necrotic cells and produce collagen fibers repair lesions caused by akoya-virus. present study, using an indirect immunofluorescence technique with anti-rFeIFN-omega rabbit serum, examined whether hemocytes...
Summary Background Lanoconazole (LCZ) is a topical antifungal agent clinically used to treat fungal infections such as tinea pedis. LCZ has not only effects but also anti‐inflammatory effects, which have the potential provide additional clinical benefits. However, characteristic features of inhibitory on skin inflammation remain unclear. Objective We evaluated application LCZ, and compared with those other agents including liranaftate, terbinafine amorolfine. Methods Each was topically...