A5087784494- Sperm and Testicular Function
- Phagocytosis and Immune Regulation
- Effects and risks of endocrine disrupting chemicals
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Liver physiology and pathology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Bladder and Urothelial Cancer Treatments
- Xenotransplantation and immune response
- Multiple and Secondary Primary Cancers
- Reproductive System and Pregnancy
- Cancer Mechanisms and Therapy
- Hormonal and reproductive studies
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Cambodian History and Society
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Fibroblast Growth Factor Research
- Esophageal Cancer Research and Treatment
- Viral Infections and Outbreaks Research
- interferon and immune responses
Oracle (United States)
2024
Cerner (United States)
2023
Washington University in St. Louis
2021
The University of Texas at Austin
2017-2019
Medical Research Council
2015-2017
Centre for Inflammation Research
2016-2017
University of Edinburgh
2016-2017
Queen's Medical Centre
2016
BackgroundCells undergoing apoptosis are known to modulate their tissue microenvironments. By acting on phagocytes, notably macrophages, apoptotic cells inhibit immunological and inflammatory responses promote trophic signaling pathways. Paradoxically, because of potential cause death tumor thereby militate against malignant disease progression, both tumor-associated macrophages (TAMs) often associated with poor prognosis in cancer. We hypothesized that, progression disease, constitutive...
The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This activates the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses essential viral spread in lung. Utilizing rational structure-based design (SBDD) coupled to substrate specificity screening TMPRSS2, we have discovered covalent small-molecule ketobenzothiazole (kbt) inhibitors which are structurally distinct from significantly improved...
In aggressive non-Hodgkin's lymphoma (NHL), constitutive apoptosis of a proportion the tumor cell population can promote net growth. This is associated with accumulation tumor-associated macrophages (TAMs) that clear apoptotic cells and exhibit pro-oncogenic transcriptional activation profiles characteristic reparatory, anti-inflammatory angiogenic programs. Here we consider further status these TAMs. We compare their transcriptomic profile range other macrophage types from various tissues...
Exposure of rodents to the Sertoli cell (SC) toxicant mono-(2-ethylhexyl) phthalate (MEHP) has been reported trigger an infiltration macrophages into testis in age- and species-dependent manner. Here we challenge hypothesis that peripubertal rat-specific after MEHP exposure is due, part, increase SC-specific inflammatory cytokine expression. To rule out germ cell(GC) apoptosis itself responsible for macrophage recruitment, rats were exposed a direct GC toxicant, methoxyacetic acid (MAA), but...
Peripubertal exposure of male rodents to the phthalate metabolite mono-(2-ethylhexyl) (MEHP) causes testicular inflammation, spermatocyte apoptosis, and disruption blood-testis barrier. The MEHP-induced inflammatory response in testis includes an infiltration macrophages neutrophils, although cause purpose this is unknown. Recently, a population known as peritubular that are phenotypically distinct from those resident interstitium was described mice. Peritubular aggregate near spermatogonial...
The testis is an organ that maintains immune suppressive environment. We previously revealed exposure of pre-pubertal rats to acute dose a well-described Sertoli cell toxicant, mono-(2-ethylhexyl) phthalate (MEHP), leads accumulation CD11b+ cells in the testicular interstitial space closely correlates with robust incidence germ (GC) apoptosis. Here, we test hypothesis infiltrating contribute GC Postnatal day 28 Fischer received oral 700 mg/kg MEHP showed significant infiltration both...
Hepatocyte growth factor (HGF), the ligand for MET receptor tyrosine kinase, is a tumor-promoting that abundant in tumor microenvironment. Proteolytic activation of inactive pro-HGF by one or more serine endopeptidases matriptase, hepsin, and HGF activator rate-limiting step HGF/MET signaling. Herein, we have rationally designed novel class side chain cyclized macrocyclic peptide inhibitors. The new series cyclic tripeptides has superior metabolic stability significantly improved...
Abstract The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This activates the Spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and other coronaviruses essential viral spread in lung. Utilizing rational structure-based design (SBDD) coupled to substrate specificity screening TMPRSS2, we have discovered a novel class small molecule ketobenzothiazole inhibitors with significantly improved activity over existing...
479 Background: Incidence and mortality for BC has changed very little over the past 20 years. Approximately 40% of patients with high-risk non-muscle invasive eventually recur/progress. It is important to understand economic impact disease recurrence/progression in BC. Methods: An model was constructed calculate number receiving each treatment modality at every stage their respective costs. Epidemiological data based on CancerMPact Patient Metrics (PM) database, retrieved from CMP Treatment...
Incidence and mortality for bladder cancer has changed very little over the past 20 years. Approximately 40% of patients with high-risk nonmuscle invasive eventually recur/progress. It is important to understand economic impact disease recurrence/progression in cancer. Our aim was estimate direct costs associated treatment from payer's perspective USA, year 2021, including both newly diagnosed (stages 0a-IV) recurrent patients.
Abstract Overproduction of Hepatocyte Growth Factor (HGF) in the tumor microenvironment by tumor-associated fibroblasts or cancer cells is associated with poor patient outcomes and a common cause therapeutic resistance. HGF signals via MET receptor, which results activation downstream signaling pathways that promote cell survival, proliferation, migration, scattering, invasion cells. secreted as an inactive precursor, pro-HGF, proteolytic processing into its active form one serine proteases,...
Abstract The testis is an immune-privileged organ that maintains immune suppressive environment. We have previously shown exposure of postnatal day (PND) 28 Fischer rats to acute dose the Sertoli cell toxicant MEHP leads accumulation CD11b+ cells in testicular interstitium correlates with a robust incidence germ (GC) apoptosis. Here we hypothesize infiltrating contribute GC PND received oral 700 mg/kg showed significant infiltration both CD11bc+/CD68+/CD163− macrophages and neutrophils,...
A bstract Peripubertal exposure to the phthalate metabolite mono-(2-ethylhexyl) (MEHP) in rodents causes testicular inflammation, spermatocyte apoptosis, and disruption of blood-testis barrier. The MEHP-induced inflammation response includes an infiltration macrophages neutrophils testes, although cause purpose this is unknown. Recently, a population phenotypically distinct from those resident interstitium was described mice. Testicular peritubular aggregate near spermatogonial stem cell...