A5039699545- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Bone Tissue Engineering Materials
- Orthopedic Infections and Treatments
- Dental Implant Techniques and Outcomes
- Bone fractures and treatments
- Sarcoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- Hip disorders and treatments
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Electrospun Nanofibers in Biomedical Applications
- Tribology and Wear Analysis
- Osteoarthritis Treatment and Mechanisms
- Dental materials and restorations
- Advanced materials and composites
- Reconstructive Surgery and Microvascular Techniques
- Periodontal Regeneration and Treatments
- Hip and Femur Fractures
- Bone health and treatments
- Shoulder and Clavicle Injuries
- Bone Tumor Diagnosis and Treatments
- Tissue Engineering and Regenerative Medicine
University of Portsmouth
2018-2025
University College London
2014-2024
Stanmore College
2007-2024
Uppsala University
2024
Curtin University
2024
Sir Charles Gairdner Hospital
2024
Murdoch University
2024
Royal Perth Hospital
2024
Royal National Orthopaedic Hospital
2013-2022
John Wiley & Sons (United States)
2019
Resorbable Mg and alloys have gained significant interest as promising biomedical materials. However, corrosion of these can lead to premature reduction in their mechanical properties, therefore rate needs be controlled. The aim this study is select an appropriate environment where the effects coatings on underlying alloy discerned measured a relatively short time period. resistance uncoated AZ31 different solutions [Hank's Balanced Salt Solution, 1× phosphate buffered solution (PBS), 4×...
There is increased pressure by governments and industry to develop national surveillance programmes evaluate antimicrobial usage (AMU) in animals.This article presents a methodological approach cost-effectiveness analysis of such programmes.Seven objectives are proposed for AMU animals: quantifying use, finding trends, detecting hotspots, identifying risk factors, encouraging research, evaluating the impact policies diseases, demonstrating compliance with regulations.Achieving these would...
The three-dimensional architecture of bovine articular cartilage collagen and its relationship to split lines has been studied with scanning electron microscopy. In the middle superficial zones, was organised in a layered or leaf-like manner. orientation vertical intermediate zone, curving become horizontal parallel surface zone. Each leaf consisted fine network fibrils. Adjacent leaves merged were closely linked by bridging fibrils arranged according split-line pattern. layer (lamina...
From a literature survey, it was evident that wide variety of kinematic conditions occur at the femoral-tibial bearing surfaces, including various degrees rolling and sliding. A test machine constructed to reproduce these conditions, applied spherical-ended metal 'femoral' components acting on flat polyethylene 'tibial' plateau. The load cyclic 2.2 kN for 10 million cycles with distilled water lubricant. For only, shiny depression formed. With oscillating sliding superimposed, there severe...
We treated 98 patients with peri-acetabular tumours by resection and reconstruction a custom-made pelvic endoprosthesis. The overall survival of the was 67% at five years, 54% ten years 51% 30 years. One or more complications occurred in 58.1% (54), which infection most common, affecting 30% (28 patients). rate local recurrence 31% (29 patients) after mean follow-up 71 months (11 to 147). Dislocation 20% (19). Before 1996 40.5% (17 but this reduced 3.9% (two introduction larger femoral head....
ABSTRACT It has been speculated that material loss, either as corrosion or wear, at the head–stem taper junction is implicated in high revision rates reported for metal‐on‐metal total hip replacements. We measured volume of loss from and bearing surfaces retrieved devices, investigated associations with blood metal ion levels diagnosis a cystic solid pseudotumor. The median volumes lost female male were 2.0 0.29 mm 3 , respectively, while wear cup head 1.94 3.44 respectively. Material was...
ABSTRACT Widespread concern exists about adverse tissue reactions after metal‐on‐metal (MoM) total hip replacement (THR). Concerns have also been expressed with wear and corrosion of taper junctions in THR. We report the effect surface finish contact area associated a single combination materials modular tapers. In an vitro test, we investigated head/neck (CoCrMo/Ti) interface THRs using commercially available heads. Wear surfaces was compared following 10 million loading cycle. Surface...
An increasing volume of work supports utilising the mechanobiology bone for ingrowth into a porous scaffold. However, typically during in vivo testing implants, mechanical properties being replaced are not quantified. Consequently there remains inconsistencies literature regarding 'optimum' pore size and porosity ingrowth. It is also difficult to compare results between studies translate animal human subjects without understanding environment. This study presents clinically applicable...
This research investigates the accelerated hydrolytic degradation process of both anatomically designed bone scaffolds with a pore size gradient and rectangular shape (biomimetically or bricks). The effect material composition is investigated considering poly-ε-caprolactone (PCL) as main scaffold material, reinforced ceramics such hydroxyapatite (HA), β-tricalcium phosphate (TCP) bioglass at concentration 20 wt%. In case scaffolds, (200 μm, 300 μm 500 μm) also investigated. (accelerated...
Abstract Transplantation of gene-modified mesenchymal stem cells (MSCs) in animals for bone regeneration therapy has been evaluated extensively recent years. However, increased endosteal formation by intravenous injection MSCs ectopically expressing a foreign gene not yet shown. Aside from the clearance lung and other tissues, surface compositions may favor their marrow (BM) migration engraftment. To overcome these hurdles, encoding chemokine receptor largely responsible stromal-derived...
The objective of this study was to examine the degree osteointegration into a hydroxyapatite-coated collar and relate finding aseptic loosening in patients with distal femoral replacement used treat primary bone cancer. Our hypothesis that implant would increase reduce rate loosening.Sixty-one treated cemented prosthesis between 1992 2001 were included study. mean duration follow-up 8.5 years (range, two eighteen years). Extracortical growth grooved quantified radiographically. Histological...
This study explored the regenerative osteogenic response in distal femur of sheep using scaffolds having stiffness values within, and above below, range trabecular bone apparent modulus. Scaffolds 3D-printed from stiff titanium compliant polyamide were implanted into a cylindrical metaphyseal defect 15 × mm. After six weeks, ingrowth varied between 7 21% scaffold pore volume this was generally inversely proportional to stiffness. The individual reparative considerably among animals, which...