A5105770476- Genetic Associations and Epidemiology
- Developmental Biology and Gene Regulation
- Substance Abuse Treatment and Outcomes
- Congenital heart defects research
- Epigenetics and DNA Methylation
- Smoking Behavior and Cessation
- Chromosomal and Genetic Variations
- Alcohol Consumption and Health Effects
- Nicotinic Acetylcholine Receptors Study
- RNA modifications and cancer
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Genetics and Neurodevelopmental Disorders
- Homelessness and Social Issues
- Zebrafish Biomedical Research Applications
- Employment and Welfare Studies
- Machine Learning in Bioinformatics
- Cardiomyopathy and Myosin Studies
- TGF-β signaling in diseases
- Cellular transport and secretion
- Child Development and Digital Technology
- Studies on Chitinases and Chitosanases
- HIV, Drug Use, Sexual Risk
Washington University in St. Louis
2002-2018
VA Eastern Kansas Health Care System
2017-2018
University College London
2018
EP Analytics (United States)
2017
New York Medical College
1991
Metropolitan Hospital Center
1991
Lancelets (‘amphioxus’) are the modern survivors of an ancient chordate lineage, with a fossil record dating back to Cambrian period. Here we describe structure and gene content highly polymorphic ∼520-megabase genome Florida lancelet Branchiostoma floridae, analyse it in context evolution. Whole-genome comparisons illuminate murky relationships among three groups (tunicates, lancelets vertebrates), allow not only reconstruction complement last common ancestor but also partial its genomic...
Abstract Small GTP-binding proteins regulate diverse processes in eukaryotic cells such as signal transduction, cell proliferation, cytoskeletal organization, and intracellular membrane trafficking. These function molecular switches that cycle between “active” “inactive” states, this is linked to the binding hydrolysis of GTP. The Arabidopsis genome contains 93 genes encode small protein homologs. Phylogenetic analysis these shows plants contain Rab, Rho, Arf, Ran GTPases, but no Ras...
Risk-taking behaviour is a key component of several psychiatric disorders and could influence lifestyle choices such as smoking, alcohol use, diet. As phenotype, risk-taking therefore fits within Research Domain Criteria (RDoC) approach, whereby identifying genetic determinants this trait has the potential to improve our understanding across different disorders. Here we report genome-wide association study in 116,255 UK Biobank participants who responded yes/no question "Would you consider...
Background There is evidence that low‐level alcohol use, drinking 1 to 2 drinks on occasion, protective for cardiovascular disease, but increases the risk of cancer. Synthesizing overall impact use health therefore complex. The objective this paper was examine association between frequency and mortality. Methods Two data sets with self‐reported mortality follow‐up were analyzed: 340,668 individuals from National Health Interview Survey (NHIS) 93,653 Veterans Administration (VA) outpatient...
The purpose of this study was to develop and determine the validity a patient-completed questionnaire that assesses metered-dose inhaler (MDI) technique. Self-reported MDI technique compared observed included nine steps for use, with two three response choices each step. A total 159 patients were studied. Direct observation revealed greater than 82% exhibited inadequate (more out incorrect). mean percentage agreement between 77.4%. Questionnaire results where in higher when performed correct
Abstract The widely accepted notion that two whole‐genome duplications occurred during early vertebrate evolution (the 2R hypothesis) stems from the fact vertebrates often possess several genes corresponding to a single invertebrate homolog. However number of predicted by Human Genome Project is less than twice as many in Drosophila melanogaster or Caenorhabditis elegans genomes. This ratio could be explained rounds genome duplication followed extensive gene loss, duplication, sequential...
Abstract We have identified an amphioxus T‐box gene that is orthologous to the Eomesodermin , T‐brain‐1 and Tbx21 genes of vertebrates, we characterized its expression pattern during embryonic larval development. AmphiEomes/Tbr1/Tbx21 maternally expressed in oocytes cleavage stage embryos. After onset zygotic transcription at blastula stage, it invaginating mesendoderm cells gastrulation, but downregulated presumptive ectoderm neurectoderm. Expression seen both axial paraxial neurulae early...
Amphioxus and vertebrates are the only deuterostomes to exhibit unequivocal somitic segmentation. The relative simplicity of amphioxus genome makes it a favorable organism for elucidating basic genetic network required chordate somite development. Here we describe developmental expression marker, AmphiTbx15/18/22, which is first expressed at mid-gastrula stage in dorsolateral mesendoderm. At early neurula stage, detected three pairs developing somites. By mid-neurula downregulated anterior...
Abstract Risk-taking behaviour is a key component of several psychiatric disorders and could influence lifestyle choices such as smoking, alcohol use diet. As phenotype, risk-taking therefore fits within Research Domain Criteria (RDoC) approach, whereby identifying genetic determinants this trait has the potential to improve our understanding across different disorders. Here we report genome wide association study in 116 255 UK Biobank participants who responded yes/no question “Would you...
Abstract Importance Current recommendations for low-risk drinking are based on quantity: up to one drink daily women and two drinks men. Drinking frequency has not been independently examined its contribution mortality. Objective To evaluate the impact of all-cause mortality after adjusting per day binge behavior. Design Two independent observational studies with self-reported alcohol use subsequent mortality: National Health Interview Survey (NHIS), data from Veteran’s Administration...
Abstract Background There are high levels of comorbidity between schizophrenia and substance use disorder, but little is known about the genetic etiology this comorbidity. Methods Here, we test hypothesis that shared liability contributes to rates disorder. To do this, polygenic risk scores for derived from a large meta-analysis by Psychiatric Genomics Consortium were computed in three disorder datasets: COGEND (ascertained nicotine dependence n=918 cases, 988 controls), COGA alcohol n=643...
Our hypothesis was that a one-day survey of all patients hospitalized on Adult General Care would demonstrate need for expanded addiction services in municipal teaching hospital East Harlem. We interviewed 276 February 16, 1990 to assess whether they abused drugs or alcohol were reasons related substance use. Of the interviewed, 18 percent used alone, 14 17 both and 2 One hundred forty 51 admitted because use its sequelae as result violence associated with buying selling drugs. The...