A5073029816- Computational Drug Discovery Methods
- Animal testing and alternatives
- Histone Deacetylase Inhibitors Research
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Carcinogens and Genotoxicity Assessment
- Pharmacological Effects and Toxicity Studies
- Gene expression and cancer classification
- bioluminescence and chemiluminescence research
- Molecular Biology Techniques and Applications
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Medicinal Plants
Procter & Gamble (United States)
2014-2022
Connectivity mapping is a method used in the pharmaceutical industry to find connections between small molecules, disease states, and genes. The concept can be applied predictive toxicology paradigm chemicals, adverse events, In order assess applicability of technique for purposes, we performed gene array experiments on 34 different chemicals: bisphenol A, genistein, ethinyl-estradiol, tamoxifen, clofibrate, dehydorepiandrosterone, troglitazone, diethylhexyl phthalate, flutamide, trenbolone,...
Abstract A key step in the risk assessment process of a substance is its genotoxic potential. Irrespective industry involved, current approaches rely on combinations two or three vitro tests and while highly sensitive, their specificity thought to be limited. refined genotoxicity testing strategy with improved predictive capacity would beneficial “3R” friendly as it helps avoid unnecessary vivo follow‐up testing. Here, we describe proof concept study evaluating balanced set compounds that...
Abstract The purpose of this study was to use chemical similarity evaluations, transcriptional profiling, in vitro toxicokinetic data, and physiologically based pharmacokinetic (PBPK) models support read-across for a series branched carboxylic acids using valproic acid (VPA), known developmental toxicant, as comparator. chemicals included 2-propylpentanoic 2-ethylbutanoic acid, 2-ethylhexanoic (EHA), 2-methylnonanoic 2-hexyldecanoic 2-propylnonanoic (PNA), dipentyl acetic or...