A5100431376- Geotechnical Engineering and Analysis
- Geotechnical Engineering and Underground Structures
- Grouting, Rheology, and Soil Mechanics
- Geomechanics and Mining Engineering
- Civil and Geotechnical Engineering Research
- Geoscience and Mining Technology
- Geotechnical Engineering and Soil Stabilization
- Tunneling and Rock Mechanics
- Railway Engineering and Dynamics
- Rock Mechanics and Modeling
- Landslides and related hazards
- Structural Response to Dynamic Loads
- Structural Behavior of Reinforced Concrete
- Electric and Hybrid Vehicle Technologies
- Advanced Battery Technologies Research
- High Entropy Alloys Studies
- Structural Load-Bearing Analysis
- Evaluation and Optimization Models
- Saffron Plant Research Studies
- Innovative concrete reinforcement materials
- Dam Engineering and Safety
- Infrastructure Maintenance and Monitoring
- Flavonoids in Medical Research
- Industrial Technology and Control Systems
- Asphalt Pavement Performance Evaluation
Shihezi University
2019-2025
Central South University
2017-2025
Xinjiang Production and Construction Corps
2023-2025
Michigan Center for Translational Pathology
2024
University of Michigan
2024
Xi'an Technological University
2020-2024
University of Science and Technology of China
2024
Shandong Jianzhu University
2023
Zhejiang Provincial Institute of Communications Planning,Design & Research
2023
Ningbo University of Technology
2023
Cyclin-dependent kinases 12/13 play pivotal roles in orchestrating transcription elongation, DNA damage response, and maintenance of genomic stability. Biallelic CDK12 loss has been documented various malignancies. Here, we develop a selective CDK12/13 PROTAC degrader, YJ9069, which effectively inhibits proliferation subsets prostate cancer cells preferentially over benign immortalized cells. degradation rapidly triggers gene-length-dependent transcriptional elongation defects, leading to...
Metro tunnels are often constructed between dense building foundations and underground pipelines, thus the spacing adjacent is usually small. A decrease in can significantly increase severity of tilting piles or ground settlement on either side metro. In order to analyse response surface buildings, as well movement piles, field monitoring numerical simulations were carried out for a section three small-spacing tunnels. three-stage analysis method was proposed calculation curve induced by...
Shield tunnel backfill grouting is vital to stabilize settlement at a later stage; however, most shield designs lack complete theoretical reference, and numerical simulations of the process are rarely conducted. This study presents fundamental theories grout diffusion pressure variation for during construction. Moreover, simulation methods coupled with discrete element (DEM) finite difference (FDM) achieved simulate injection from hole into tail gap generate on surrounding rock. The state in...
Resveratrol shows promizing anti-inflammatory effects in recent clinical trials, however its function cardiovascular patients remains conflicting, suggesting there may be new mechanisms underlying cardioprotective activity. Acute sympathetic stress induces early activation of the NLR family, pyrin domain containing 3 (NLRP3) inflammasome cardiomyocytes as a critical step for triggering cardiac inflammation. Thus, this study explored targets resveratrol activity involved inhibition following...
To ensure the safety and stability of shield tunnel construction process, ground settlement induced by needs to be effectively predicted. In this paper, a prediction method combining empirical mode decomposition (EMD), chaotic adaptive sparrow search algorithm (CASSA), extreme learning machine (ELM) is proposed. First, EMD used decompose sequence into trend vectors fluctuation fully extract effective information sequence; Second, improved introducing Cubic mapping initialize population...
With the increasing complexity of engineering environments in tunnel construction, vibrations generated by shield tunneling hard rock strata pose significant challenges to operation and maintenance adjacent tunnels. This study investigates vibration characteristics induced provides an in-depth analysis propagation behavior these within segments surrounding soil layers. Through a combination theoretical derivations, on-site monitoring, numerical simulations, research examines distribution...
During metro tunnel construction, Tunnel Boring Machine(TBM) often induces surface and nearby pile vibrations. However, these vibrations are overlooked due to the short-term passage of cutterhead beneath foundation structures. In fact, had adverse effects on certain sensitivity Therefore, analyze dynamic characteristics environmental induced by TBM, on-site vibration monitoring a numerical modeling method coupling Discrete Element Method with Finite Difference were employed for research. The...
This paper investigates the frost heave and thaw settlement characteristics of pipe–soil system during freeze–thaw cycle, along with underlying mechanisms. A numerical simulation platform for complex was developed using heat conduction equation, moisture migration stress–strain all which account ice–water phase change process. The simulations were performed coefficient-type partial differential equation (PDE) module in COMSOL Multiphysics. By employing coupled thermal–hydraulic–mechanical...
Vibrations generated by shield tunnel construction in hard rock strata can have adverse effects on the surrounding environment. To investigate mutual interference of three-dimensional vibrations and propagation characteristics vibration waves during process, this study is based project a Jinan urban rail transit zone. The research integrates on-site monitoring, FLAC3D numerical simulations, theoretical analysis transfer functions. results show that: 1)Single-direction input has greatest...
Abstract To address the issues of temperature cracks and water leakage in support structure deep large freezing shafts western China, high-performance concrete incorporating steel fibers fly ash was proposed as a wall construction material. First, an orthogonal experimental design conducted by considering three factors: strength grade, fiber content, content. Based on mechanical performance analysis range analysis, optimal mix ratio for determined cement: ash: admixture: stone: sand: water:...
Using the Nanjing Dinghuaimen Yangtze River Tunnel project as a case study, we proposed method to reuse excavated silty-fine sand by adjusting proportion of waste replace commercial sand. This would address issue recycling significant amount generated when slurry shield passes through stratum. Moreover, have evaluated grout indicators such density, fluidity, consistency, bleeding rate, volumetric shrinkage, setting time, and unconfined compressive strength examined how particle size...
Abstract Due to the lack of a perfect and convenient method detect grouting quality shield tunnels, an optimized ultrasonic phased array tunnel detection technology is proposed. The particle swarm genetic algorithm be used for sparse, GA-VMD-SG proposed noise reduction signals, numerical simulation experimental methods are validate effect array. results show that: GA-PSO can better simplify reduce maximum sidelobe value; well signals; experiments verify feasibility optimization two algorithms.
Excavation of subway tunnels in hard rock generates strong vibration waves that pose potential risks to the stability surrounding structures. In this study, discrete element method-finite difference method (DEM-FDM) coupling was adopted build model tunnel structure-rock-pile, which validated by field monitoring data. Then, response piles under various pile-tunnel spacings analyzed, revealing occurrence peak rebound phenomena within certain distance ranges. The range effects categorized....
Extreme vertical impact loading from dropped heavy cargo or falling rocks threatens the safety of bridge structures. The behavior and post-impact performance a multi-piece prestressed concrete (PC) box girder were investigated through numerical simulation. moment-curvature analysis was performed to explain damage mechanism predict residual capacity under impact. results demonstrate that impacted suffers most severe flexural failure whereas other un-impacted girders exhibit flexural-torsional...